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Autor:
Hideki Arimochi, Shin-ichi Tsukumo, Hisanori Uehara, Yuki Sasaki, Thiranut Jaroonwitchawan, Kunihiro Otsuka, Tomoko Kobayashi, Koji Yasutomo, Michittra Boonchan
Publikováno v:
Cell Death and Disease, Vol 12, Iss 6, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
The sensing of various extrinsic stimuli triggers the receptor-interacting protein kinase-3 (RIPK3)-mediated signaling pathway, which leads to mixed-lineage kinase-like (MLKL) phosphorylation followed by necroptosis. Although necroptosis is a form of
Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Yan Zheng, Haoting Sun, Mo Chen, Yuan-Yuan Sheng, Lun-Xiu Qin, Qiongzhu Dong, Xudong Ren, Qin Luo, Bei-Yuan Hu, Yan Geng, Tiantian Zou, Xiao-Mei Gao, Kai-Li Zhang, Chaoqun Wang, Lu-Yu Yang, Shican Yan, Yan Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown. Exosomes released by tumor cells have been proved to be effective cell-to-cell signal m
Autor:
Christine Hartmann, Lena I. Wolff, Jessica Bertrand, Christine Fabritius, Stefan Teufel, Petra Köckemann, Thomas Pap
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Agonists and antagonists of the canonical Wnt signaling pathway are modulators of pathological aspects of rheumatoid arthritis (RA). Their activity is primarily modifying bone loss and bone formation, as shown in animal models of RA. More recently, m
Autor:
Wanning Zhang, Xuehui Wu, Yanqing Ding, Xiaoli Ren, Yongrong Yan, Li Liang, Zhicheng Zeng, Yumei He, Wangjun Liao, Feifei Wang, Wei Yang, Jianbiao Xiao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-15 (2021)
Cell Death & Disease
Cell Death & Disease
In colorectal cancer (CRC), overt metastases often appear after years of latency. But the signals that cause micro-metastatic cells to remain indolent, thereby enabling them to survive for extended periods of time, are unclear. Immunofluorescence and
Autor:
Gaia Spinetti, Mario Tirone, Pasquale Creo, Simona Greco, Matteo Carrara, Paola Fuschi, Davide Maselli, Carlo Gaetano, Massimiliano Mazzone, Biagina Maimone, Fabio Martelli, Christine Voellenkle, Germana Zaccagnini, Marialucia Longo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 5, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Hypoxia-induced miR-210 is a crucial component of the tissue response to ischemia, stimulating angiogenesis and improving tissue regeneration. Previous analysis of miR-210 impact on the transcriptome in a mouse model of hindlimb ischemia showed that
Autor:
Jianmin Yang, Cheng Zhang, Shanshan Liu, Wencheng Zhang, Hongxuan Li, Jingjing Wang, Xiuxin Jiang, Xiuru Cui, Shangming Liu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
Human antigen R (HuR) is a widespread RNA-binding protein involved in homeostatic regulation and pathological processes in many diseases. Atherosclerosis is the leading cause of cardiovascular disease and acute cardiovascular events. However, the rol
Autor:
Takashi Nakamura, Mai Nampei, Takayo Murase, Hiroki Mizukami, Noriaki Katoh, Seigo Akari, Etsuko Satoh
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-5 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Plasma xanthine oxidoreductase (XOR) activity is high in metabolic disorders such as diabetic mellitus, obesity, or overweight. Thus, this study investigated whether the XOR inhibitor, topiroxostat, affected body weight. Male db/db mice were fed stan
Autor:
Tharick A. Pascoal, Julyanna A. Peny, Elisa de Paula França Resende, Érica Leandro Marciano Vieira, Natalia M. Lyra e Silva, Isadora C. Furigo, Julia R. Clarke, Ricardo A.S. Lima-Filho, Antônio Lúcio Teixeira, Beatriz M. Longo, Pedro Rosa-Neto, Debora Hashiguchi, Jose Donato, Juliana T.S. Fortuna, Vivian S. Miya-Coreixas, Paulo Caramelli, Paul E. Fraser, Fernanda G. De Felice, Rafaella Araujo Gonçalves, Leonardo Cruz de Souza, Jose F. Abisambra, Sergio T. Ferreira
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-15 (2021)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Translational Psychiatry
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Translational Psychiatry
Alzheimer’s disease (AD) is associated with memory impairment and altered peripheral metabolism. Mounting evidence indicates that abnormal signaling in a brain-periphery metabolic axis plays a role in AD pathophysiology. The activation of pro-infla
Publikováno v:
International Journal of Oral Science, Vol 13, Iss 1, Pp 1-10 (2021)
International Journal of Oral Science
International Journal of Oral Science
Hyperglycemia induces chronic low-grade inflammation (inflammaging), which is a newly identified contributor to diabetes-related tissue lesions, including the inflammatory bone loss in periodontitis. It is also a secondary senescent pattern mediated