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Autor:
George A. Wells, F. Daniel Ramirez, Marino Labinaz, Jeffrey A. Marbach, Shannon M. Fernando, Aws Almufleh, Anas Merdad, Omar Abdel-Razek, Jordan Bernick, Trevor Simard, Kwadwo Kyeremanteng, Rebecca Mathew, Michael Froeschl, Juan J Russo, Benjamin Hibbert, Jordan Hutson, David T. Harnett, Willy Weng, Pietro Di Santo, Michel R. Le May, Vincent Chan, Richard G. Jung
Publikováno v:
New England Journal of Medicine. 385:516-525
Background Cardiogenic shock is associated with substantial morbidity and mortality. Although inotropic support is a mainstay of medical therapy for cardiogenic shock, little evidence exis...
Autor:
Natalie Carvalho, Christopher K Fairley, Fabian Y S Kong, Eric P F Chow, David G. Regan, Jane S Hocking, Andrew Lau, Mark A. Boyd, Mahesh Ratnayake, Carole Khaw, Janaki Amin, Samuel Phillips, Anna McNulty, Basil Donovan, John M. Kaldor, David J Templeton, Catriona S. Bradshaw, David A. Lewis, Peter Timms, Matthew Law, Marcus Y Chen
Publikováno v:
New England Journal of Medicine. 384:2418-2427
Background Rectal chlamydia is a common bacterial sexually transmissible infection among men who have sex with men. Data from randomized, controlled trials are needed to guide treatment. M...
Autor:
Edmond O’Loughlin, Matthew T. V. Chan, Kate Leslie, Allen C. Cheng, Andrew Forbes, Catherine Martin, Leon A. Bach, Timothy G. Short, Pauline Coutts, Kwok M. Ho, Paul S. Myles, Tomas Corcoran, David A Story
Publikováno v:
New England Journal of Medicine. 384:1731-1741
The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.In this pragmatic, international, noninferiority trial, we randomly assigned 8880 adult patient
Publikováno v:
Hieronymus, F & Østergaard, S D 2021, ' Psilocybin for Depression ', The New England Journal of Medicine, vol. 385, no. 9, pp. 862-863 . https://doi.org/10.1056/NEJMc2108082
Autor:
Guadalupe Garcia-Tsao
Publikováno v:
New England Journal of Medicine. 384:869-871
Decompensated cirrhosis is defined by the presence of ascites, variceal hemorrhage, hepatic encephalopathy, or a combination of these disorders. A stage of further decompensation occurs with the de...
Autor:
Fyezah Jehan, Anita K. M. Zaidi, Imran Nisar, Najeeb Rahman, Benazir Balouch, Arjumand Rizvi, Nicholas M. Brown, Salima Kerai, Yasir Shafiq
Publikováno v:
New England Journal of Medicine. 383:24-34
Background The World Health Organization (WHO) recommends oral amoxicillin for patients who have pneumonia with tachypnea, yet trial data indicate that not using amoxicillin to treat this ...
Autor:
Ginsburg, Amy Sarah, Mvalo, Tisungane, Nkwopara, Evangelyn, McCollum, Eric D., Phiri, Melda, Schmicker, Robert, Hwang, Jun, Ndamala, Chifundo B., Phiri, Ajib, Lufesi, Norman, Izadnegahdar, Rasa, May, Susanne
Publikováno v:
The New England Journal of Medicine
BACKGROUND Evidence supporting duration of antibiotic treatment for children in low-resource African settings with chest-indrawing pneumonia is lacking. METHODS We conducted a double-blind, randomized controlled 2-arm, non-inferiority trial in Lilong
Publikováno v:
New England Journal of Medicine. 382:2569-2572
Anticonvulsant Medications to Manage Epilepsy This interactive feature about a woman with idiopathic generalized epilepsy that has progressed to status epilepticus offers a case vignette accompanie...
Autor:
Majed Alabdulhafid, Zobaida Alsum, Fahad A. Bashiri, Abdullah A. Alangari, Jacinta Bustamante, Emmanuelle Jouanguy, Rabih Halwani, Malak Alghamdi, Hamdy H. Hassan, Dusan Bogunovic, Areej Rashid Alkahtani, Fahad Alsohime, Najla Alotaibi, Nouf Alkhamis, Mohamad-Hani Temsah, Marta Martín-Fernández, Conor Gruber, Ayman Al-Eyadhy, Saleh Al-Muhsen, Xueer Qiu, Gamal M Hasan, Tom Le Voyer, Sofija Buta, Jean-Laurent Casanova
Publikováno v:
N Engl J Med
Deficiency of ubiquitin-specific peptidase 18 (USP18) is a severe type I interferonopathy. USP18 down-regulates type I interferon signaling by blocking the access of Janus-associated kinase 1 (JAK1) to the type I interferon receptor. The absence of U
Publikováno v:
New England Journal of Medicine. 383:1592-1594
Gangrene from Anticoagulant Dilution The use of colloid for volume expansion in two patients with hemodynamic shock led to dilution of antithrombin, free protein S, and protein C and the subsequent...