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Autor:
Kozo Kaibuchi, Masaki Sone, Yoshiya Kawaguchi, Shinichiro Taya, Yusuke Seto, Kentaro Ichijo, Shogo Aida, Tomoo Owa, Tomoki Nishioka, Mariko Yamashita, Mikio Hoshino, Satoshi Miyashita
Publikováno v:
EMBO J
During development, neural progenitors are in proliferative and immature states; however, the molecular machinery that cooperatively controls both states remains elusive. Here, we report that cyclin D1 (CCND1) directly regulates both proliferative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d1bcf7b666b0b1d0234a2005dfebe1
https://europepmc.org/articles/PMC10106980/
https://europepmc.org/articles/PMC10106980/
Autor:
Liang Wang, Dan Tao, Fuqing Zeng, Guosong Jiang, Xingyuan Xiao, Chao Huang, Dong Liu, Yawei Li, Fei Xie, Fuxin Zheng, Miao Wang
Publikováno v:
EMBO Rep
Increasing evidences suggest that circular RNAs (circRNAs) exert crucial functions in regulating gene expression. In this study, we perform RNA‐seq and identify 6,154 distinct circRNAs from human bladder cancer and normal bladder tissues. We find t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea36af0ce92eba6bad8b9f054e685bd0
https://europepmc.org/articles/PMC9638867/
https://europepmc.org/articles/PMC9638867/
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 24, Pp 8789-8798 (2021)
Cancer Medicine, Vol 10, Iss 24, Pp 8789-8798 (2021)
Preclinical observations that killing of chronic lymphocytic leukemia (CLL) cells was dexamethasone (DEX) were enhanced by concomitant inhibition of Bruton’s tyrosine kinase and janus kinases (JAKs) motivated a phase II trial to determine if clinic
Autor:
Stephan B. Felix, Lutz Binder, Kathleen Nolte, Christoph Herrmann-Lingen, Rolf Wachter, Ulrich Laufs, Helge Haarmann, Stefan Gross, Frank T. Edelmann, Gerd Hasenfuß, Christian Becker, Marcus Dörr, Daniela Husser, Meinhard Mende, Martin Scherer, Stefanie Maria Werhahn, Samira Zeynalova, Astrid Petersmann, Nikolaos Dagres, Markus W. Löffler, Burkert Pieske
Publikováno v:
ESC Heart Failure
ESC Heart Failure, Vol 9, Iss 1, Pp 100-109 (2022)
ESC Heart Failure, Vol 9, Iss 1, Pp 100-109 (2022)
Aims Heart failure (HF) and atrial fibrillation (AF) frequently coexist and are both associated with increased levels of N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP). It is known that AF impairs the diagnostic accuracy of NT‐proBNP
Chronic exogenous ketone supplementation blunts the decline of cardiac function in the failing heart
Autor:
Heidi L. Silver, Shubham Soni, Mourad Ferdaoussi, Ty T. Kim, Jason R.B. Dyck, Darren H. Freed, Zaid H. Maayah, Shingo Takahara, Kiran Phaterpekar, Jody Levasseur
Publikováno v:
ESC Heart Failure
ESC Heart Failure, Vol 8, Iss 6, Pp 5606-5612 (2021)
ESC Heart Failure, Vol 8, Iss 6, Pp 5606-5612 (2021)
Aims Recent evidence has demonstrated that ketone bodies, particularly β‐hydroxybutyrate (BHB), are beneficial to the failing heart due to their potential as an alternative energy substrate as well as their anti‐inflammatory and anti‐oxidative
Autor:
Johanna Lilja, Ella-Maria Vesilahti, Johanna M. Anttila, Hussein Al-Akhrass, Johanna Ivaska, Emilia Peuhu, Pauliina Munne, Mika Pietilä, Juha Klefström, Heidi M. Haikala
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2‐related therapeutic targets could off
Autor:
Chi-Lin Kuo, Rolf G. Boot, Marta Artola, Qin Su, Lindsey T. Lelieveld, Marri Verhoek, Sybrin P. Schröder, Maria J. Ferraz, Herman S. Overkleeft, Johannes M. F. G. Aerts
Publikováno v:
Chembiochem
Chembiochem, 22, 1-10. WILEY-V C H VERLAG GMBH
Chembiochem, 22, 1-10. WILEY-V C H VERLAG GMBH
Glucocerebrosidase (GBA), a lysosomal retaining β‐d‐glucosidase, has recently been shown to hydrolyze β‐d‐xylosides and to transxylosylate cholesterol. Genetic defects in GBA cause the lysosomal storage disorder Gaucher disease (GD), and al
Autor:
Heather Carney, Scott B. Patten, Ruth Ann Marrie, Jitender Sareen, Lesley A. Graff, Carol A. Hitchon, Charles N. Bernstein, Renée El-Gabalawy, John D. Fisk, James M. Bolton, Christine A. Peschken, Mitulkumar Patel, Lisa M. Lix, Lindsay Berrigan, Kaarina Kowalec, Alan Katz, James J. Marriott, Alexander Singer
Publikováno v:
ACR Open Rheumatology
ACR Open Rheumatology, Vol 3, Iss 12, Pp 889-896 (2021)
ACR Open Rheumatology, Vol 3, Iss 12, Pp 889-896 (2021)
OBJECTIVE In this study, we aimed to determine the lifetime prevalence of substance use disorder (SUD) in a Canadian rheumatoid arthritis (RA) cohort and factors associated with SUD in RA. METHODS Participants with RA (N = 154) were recruited via rhe
Publikováno v:
Journal of clinical psychology, 77(9), 2011-2026. John Wiley and Sons Inc.
Objective: Self-focused attention is a maintaining factor for social anxiety disorder. It was shown that self-focused attention correlates with trait mindfulness, but not with attention control. This study examined the reliability and validity of the
Autor:
Uri Tabori, Vijay Ramaswamy, Donald J. Mabbott, Annie Huang, Normand Laperriere, Sharon L. Cushing, Ute Bartels, Eric Bouffet, Iska Moxon-Emre, Christine Dahl, Vicky Papaioannou
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 20, Pp 7111-7125 (2021)
Cancer Medicine, Vol 10, Iss 20, Pp 7111-7125 (2021)
Purpose We investigate the impact of severe sensorineural hearing loss (SNHL) and for the first time evaluate the effect of unilateral versus bilateral SNHL on intellectual outcome in a cohort of children with embryonal brain tumors treated with and