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Autor:
Atanas Ignatov, Piotr Czapiewski, Thomas Kalinski, Willi Pieper, Norbert Nass, Johannes Haybaeck
Publikováno v:
Cancer Biomarkers. 32:161-173
BACKGROUND: Neuronatin (NNAT) determined by immunohistochemistry is a negative prognostic biomarker for breast cancer, independent of the major clinicopathological markers. OBJECTIVE: Here, we investigated whether NNAT is also a predictive biomarker
Publikováno v:
Breast Disease. 40:S1-S7
BACKGROUND: The plasminogen urokinase activation system consists of urokinase plasminogen activator (uPA), its receptor uPAR, and plasminogen activator inhibitor type 1 (PAI-1), which are considered to have a relationship with cancer aggressiveness.
Publikováno v:
Cancer Biomarkers. 28:365-370
BACKGROUND Ovarian cancer (OC) is one of the most malignant gynecological cancers. Platelets play a profound role in cancer growth and metastasis. Platelet distribution width (PDW) is an indicator of platelet activation and is altered in malignancies
Publikováno v:
Cancer Biomarkers. 28:293-299
Background/objective CD133 is the molecular marker of normal stem cells and progenitor cells and also confirmed as a marker for cancer stem cells in various tumors. The aim of this study is to examine the expression of CD133 and assess its clinicopat
Autor:
Ching-Tung Chu, Yui Whei Chen-Yang, Chung-Kun Ho, Chia-Chi Hsieh, Hsing-Wen Lo, Jui-Chuang Wu, Vincent F.S. Tsai, Guang-Jer Wu, Yuan-Hung Pong, Yann-Rong Su
Publikováno v:
Cancer Biomarkers. 27:377-387
Background METCAM/MUC18 expression was increased with the malignant progression of prostate cancer and also a bona fide metastatic gene, capable of initiating and driving the metastasis of a non-metastatic human prostate cancer cell line to multiple
Publikováno v:
Cancer Biomarkers. 27:163-171
Background Both mitochondria and the Nrf2/Keap1 pathway are targets of cancer therapy. Reactive oxygen species released from mitochondria can activate Nrf2, and the Nrf2/Keap1 pathway affects glycolysis, oxidative phosphorylation, mitochondrial bioge
Publikováno v:
Cancer Biomarkers
Objective The EDIM (Epitope detection in monocytes) blood test is based on two biomarkers Apo10 and TKTL1. Apo10 is responsible for cell proliferation and resistance to apoptosis. TKTL1 plays a major role in anaerobic glycolysis of tumor cells, leadi
Autor:
Daley S. Morera, Jiaojiao Wang, Rohitha Baskar, Rahil Khan, Andrew Mitchell, Sarrah L. Hasanali, Charles S. Li, Asif Talukder, Daniel Albo, Roni J. Bollag, Meenakkshy Manoharan, Andre R. Jordan, Nagendra Singh, Santu Ghosh, Xin Wang, Vinata B. Lokeshwar
Publikováno v:
Cancer Biomark
BACKGROUND Differential expression of chemokines/chemokine receptors in colorectal cancer (CRC) may enable molecular characterization of patients' tumors for predicting clinical outcome. OBJECTIVE To evaluate the prognostic ability of these molecules
Publikováno v:
Cancer Biomarkers. 26:139-150
BACKGROUND No tumor biomarker (TM) is available for de novo metastatic lung adenocarcinoma. OBJECTIVE To examine the serum levels of carcinoembryonic antigen (CEA), cytokeratin-19 fragments (CYFRA21-1), neuron-specific enolase (NSE), carbohydrate ant
Autor:
Tomohito Hagi, Kouji Kita, Akihiro Sudo, Yumiko Asanuma, Yuki Yada, Kunihiro Asanuma, Tomoki Nakamura, Akihiko Matsumine, Takuya Kakimoto
Publikováno v:
Cancer Biomarkers. 26:163-170
Background Thrombomodulin (TM) has multiple biological functions and modulates not only anti-coagulation, but also cell proliferation, adhesion, and anti-inflammation activities. The main function of TM is to activate the anticoagulant pathway of pro