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Autor:
Joan W. Miller, Mary E. Aronow, Tedi Begaj, John B Miller, Lucy H. Young, Rachel M. Huckfeldt, Jan A. Kylstra, Demetrios G. Vavvas, Deeba Husain, Dean Eliott, David M. Wu, Shizuo Mukai, Leo A. Kim, Evan Chen, Sachi Patil, Lucia Sobrin, Karen M Wai, Ravi Parikh, Evangelos S. Gragoudas, Nimesh A. Patel
Publikováno v:
Seminars in Ophthalmology. 37:902-908
Purpose: To examine the effect of medication sample use (ranibizumab or aflibercept) on future anti-vascular endothelial growth factor (VEGF) agent selection in neovascular age-related macular degeneration (nvAMD). Design: Retrospective cohort study.
Autor:
Canan Yildirim, Yesim Coskun
Publikováno v:
International Journal of Neuroscience. 133:322-326
Despite the development of new antiseizure drugs (ASDs), around one third of epilepsy patients become refractory to treatment or experience adverse events due to ASDs. Therefore, discovery of new ASDs and new therapy options are crucial to improve th
Autor:
Seyed Zanyar Athari, Gisou Mohaddes, Daryoush Mohajeri, Mir Alireza Nourazar, Saeed Sadigh Eteghad, Fereshteh Farajdokht
Publikováno v:
International Journal of Neuroscience. :1-10
Background: Parkinson's disease (PD) is associated with the destruction of dopaminergic neurons in the substantia nigra (SN). Hydroxychloroquine (HCQ) has the capability to cross the blood-brain barrier and promote a neuroprotective potential. This s
Publikováno v:
Immunopharmacology and Immunotoxicology. 44:586-593
Background: Dexmedetomidine (DEX) has showed significant analgesic effects in neuropathic pain, but the underlying mechanism has remained elusive. Our present study aimed to explore the effect of DEX on hyperalgesia with the involvement of p38MAPK si
Albumin-binding tag derived Exendin-4 analogue for treating hyperglycemia and diabetic complications
Publikováno v:
Bioengineered, Vol 0, Iss 0 (2021)
Current study was conducted to design and screen a long-lasting Exendin-4 analog for treating type 2 diabetes via the novel strategy of albumin binding combined with thrombin enzymolysis. Firstly, a series of fusion peptides, containing different alb
Autor:
Lewis S. Nelson, Nicole O’Donnell, Jeanmarie Perrone, Whitney Hogg-Bremer, Jennifer S Love, Abeed Sarker, Anthony Spadaro
Publikováno v:
Clinical Toxicology. 60:694-701
Induction of buprenorphine, an evidence-based treatment for opioid use disorder (OUD), has been reported to be difficult for people with heavy use of fentanyl, the most prevalent opioid in many areas of the country. In this population, precipitated o
Autor:
M Sundaravelayutham, J Appusamy, A Ayyasamy, S Kuppannan, V Chakravarthi Periasamy, A Arivazhgan
Publikováno v:
British Poultry Science. 63:324-331
1. The following trial investigated the antigout activity and probable mechanism of Piper betle L. herb in gout-induced broiler chickens. The antioxidant and production performance modulating activity of P. betle L. was compared against the standard
Autor:
Leonidas Doumazos, Demetrios Papaconstantinou, Ilias Georgalas, Anastasios Kontaxakis, Petros Petrou, Konstantinos Droutsas, Stylianos Kandarakis
Publikováno v:
Cutaneous and Ocular Toxicology. 41:25-32
PURPOSE The aim of this study was to determine whether glaucoma patients after trabeculectomy could benefit more from subconjunctival injections of bevacizumab than 5-FU or placebo. METHODS AND RESULTS Fifty-one eyes of 51 patients were recruited for
Autor:
Zheming Gu, Zhenwen Yu, Tong Wang, Yating Xiong, Xusheng Tian, Hua Zhang, Jinsong Ding, Qiang Yu, Jinmiao Lu, Zengyan Xu, Juping Ding, Xinyi Zhou, Yicong Bian, Dong Tang
Publikováno v:
Xenobiotica. 52:38-45
1. The metabolism and excretion of cetagliptin were investigated in healthy male subjects after a single oral dose of 100mg/50μCi [14C] cetagliptin.2. The mean concentration-time profile of cetagliptin was similar to that of total radioactivity in p
Publikováno v:
Bioengineered, Vol 12, Iss 2, Pp 11947-11958 (2021)
Bioengineered
article-version (VoR) Version of Record
Bioengineered
article-version (VoR) Version of Record
Type 2 diabetes mellitus (T2DM) is known as a complex genetic disease characterized by genetic and environmental factors. The imbalanced intestinal flora and intestinal mucosal barrier are considered to be related to T2DM. Curcumin has been proved to