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Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. :1-22
Genome-wide analysis showed that putative G-quadruplex DNA structures are prevalent in the human genome. The presence of G-quadruplex structure in the telomere and promoter region of certain oncogenes inspired people to use G-quadruplex ligand as ant
Publikováno v:
Environmental Technology. 44:579-590
A packed-bed anaerobic-aerobic reactor (PBAOR) with two anaerobic and two aerobic compartments was constructed to treat manure-free piggery wastewater which was characterized by high ammonium (NH4+-N) and low ratio of chemical oxygen demand (COD) to
Publikováno v:
Environmental Technology. 44:647-658
Volatile organic compounds (VOCs) have caused a serious threat to the atmosphere and human health. Therefore, it is of great significance to exploit effective catalytic materials for the safe and effective catalytic elimination of VOCs. Herein, Ag-Mn
Publikováno v:
Cutaneous and Ocular Toxicology. 41:203-209
PURPOSE As a characteristic of age-related macular degeneration (AMD), choroidal neovascularization (CNV) causes severe vision loss. The current treatment has limited efficacy. This study was to investigate effects of Salidroside against CNV and expl
Autor:
Lingzhang Meng, Dong Li, Yingning Wu, Xuebin Li, Xiaohua Huang, Baosheng Li, Yueyong Li, Cheng Lin, Shaocai Qiu, Deyou Huang, Zhongheng Wei
Publikováno v:
Bioengineered. 13:14889-14902
Isoginkgetin is characterized by properties of potent anticancer and anti-inflammation. To explore its effect on ischemic stroke, a rat model of ischemia/reperfusion (I/R) injury was established and induced by transient middle cerebral artery occlusi
Publikováno v:
International Journal of Neuroscience. 133:123-132
Purpose: Chronic renal failure (CRF) is associated with impairment of hippocampal neurons. This study investigated the effect of PERK-eIF2α-ATF4 pathway in CRF.Methods: Rat CRF model was established and rat hippocampal neurons were separated. Xanthi
Publikováno v:
Bioengineered. 13:5598-5612
N6-Methyladenosine (m6A) is the most abundant modifications in human messenger RNAs (mRNAs). This study aimed at investigating the function and mechanism of demethyltransferase fat mass and obesity-associated protein (FTO) in prostate cancer(PCa). Th
Autor:
John Babiak, Nicole Risher, Marla Weetall, Diksha Kaushik, Shirley Yeh, Kylie O'Keefe, Valerie Northcutt, Ronald Kong, Young-Choon Moon, Ellen Welch, Lachlan Molony, Jiyuan Ma
Publikováno v:
Xenobiotica. 52:152-164
Emvododstat was identified as a potent inhibitor of dihydroorotate dehydrogenase and is now in clinical development for the treatment of acute myeloid leukaemia and COVID-19. The objective of this paper is to evaluate the metabolism, pharmacokinetics
Autor:
M Sundaravelayutham, J Appusamy, A Ayyasamy, S Kuppannan, V Chakravarthi Periasamy, A Arivazhgan
Publikováno v:
British Poultry Science. 63:324-331
1. The following trial investigated the antigout activity and probable mechanism of Piper betle L. herb in gout-induced broiler chickens. The antioxidant and production performance modulating activity of P. betle L. was compared against the standard
Publikováno v:
Pharmaceutical Development and Technology. 27:127-133
Contact lens have been proposed as a mean of ocular drug delivery, but the conventional soaking method to load hydrophobic drugs, such as latanoprost shows low drug loading and high burst release with alteration in the critical lens properties. In th