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Autor:
Nabil G. Seidah, L. Tonin, Roberta Gambaretto, A. Basak, C. Di Bello, Monica Dettin, Antonella Pasquato
Publikováno v:
Febs Letters
Infectious HIV-1 requires gp160 cleavage by furin at the REKR511 downward arrow motif (site1) into the gp120/gp41 complex, whereas the KAKR503 (site2) sequence remains uncleaved. We synthesized 41mer and 51mer peptides, comprising site1 and site2, to
Autor:
Daniel Voß, Konrad Stadler, Elisabetta Traggiai, Antonio Lanzavecchia, Stephan Becker, Anika Kern, Markus Eickmann
Publikováno v:
Febs Letters
The coronavirus membrane protein (M) is the key player in the assembly of virions at intracellular membranes between endoplasmic-reticulum and Golgi-complex. Using a newly established human monoclonal anti-M antibody we detected glycosylated and nong
Publikováno v:
FEBS Letters. (1):168-174
Hsp110 proteins constitute a heterogeneous family of abundant molecular chaperones, related to the Hsp70 proteins and exclusively found in the cytosol of eukaryotic organisms. Hsp110 family members are described as efficient holdases, preventing the
Publikováno v:
FEBS Letters. (3):186-190
An aggrecan G1-G2 substrate was used to determine sites within the interglobular domain that were susceptible to cleavage by MT1-MMP. Degradation products were identified by Western blotting with neo-epitope antibodies specific for MMP-derived N- and
Publikováno v:
FEBS Letters. (29):4083-4088
The c-MYC proto-oncogene encodes a ubiquitous transcription factor involved in cell proliferation and tumorigenesis. Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Incre
Autor:
Michael Föller, Stephan M. Huber, Ravi S. Kasinathan, Florian Lang, Camelia Lang, Saisudha Koka
Publikováno v:
FEBS Letters. (28):5407-5412
To test for redox regulation of anion channels in erythroid cells, we exposed K562 cells to oxidants and measured changes in transmembrane Cl− currents using patch-clamp, and in intracellular Cl− content using the Cl− selective dye MQAE. Oxidat
Publikováno v:
FEBS Letters. (2-3):268-274
The activity of nuclear phosphoinositide 3-kinase C2beta (PI3K-C2beta) was investigated in HL-60 cells induced to differentiate along granulocytic or monocytic lineages. A significant increase in the activity of immunoprecipitated PI3K-C2beta was obs
Publikováno v:
FEBS Letters. (1-3):277-280
Latent transforming growth factor-beta (TGF-beta) binding protein (LTBP)-1, which is easily secreted, has been shown to enhance the secretion of TGF-beta. Here we show that another member of the LTBP family, LTBP-3, is not secreted by several cell ty
Publikováno v:
FEBS Letters. (3):476-482
Several mRNAs encoding the same ferritin subunit of Drosophila melanogaster were identified. Alternative RNA splicing and utilisation of different polyadenylation sites were found to generate the transcripts. The alternative RNA splicing results in f
Autor:
Koichi Asahi, Reiko Inagi, Toshio Miyata, Koji Uchida, Yukihiro Yamada, Kiyoshi Kurokawa, Hideto Sakai, Katsunori Horie
Publikováno v:
FEBS Letters. (1-2):24-28
Accumulation of carbonyl derivatives of proteins (protein carbonyl) is taken as a biomarker of oxidative protein damage in aging and in various diseases. We detected protein carbonyls in situ in human diabetic arteriosclerotic tissues and characteriz