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Autor:
Jyrki P. Kukkonen, Lisa Johansson, Johnny Näsman, Jaana Putula, Laura Korhonen, Runar Ra, Pauli M. Turunen
Publikováno v:
FEBS Letters. (9):1368-1374
We wanted to analyze the basis for the distinction between OX(1) and OX(2) orexin receptors by the known agonists, orexin-A, orexin-B and Ala(11), D-Leu(15)-orexin-B, of which the latter two show some selectivity for OX(2). For this, chimaeric OX(1)/
Publikováno v:
FEBS Letters. (1-2):188-198
The three genes hTAF(II)68, EWS, and TLS (called the TET family) encode related RNA binding proteins containing an RNA recognition motif and three glycine-, arginine-, and proline-rich regions in the C-terminus and a degenerated repeat containing the
Publikováno v:
FEBS Letters. (17):2782-2788
The gating of the hERG channel is regulated by its eag domain through molecular interaction with either the cyclic nucleotide-binding homology domain (CNBHD) or the linker between transmembrane segments 4 and 5. Our NMR study on the purified CNBHD de
Publikováno v:
FEBS Letters. (28):5418-5424
Human Topors has originally been identified as binding partner of p53 and DNA topoisomerase I (TOP1). It can function as both an ubiquitin and SUMO-1 E3 ligase for p53. Here we demonstrate that Topors enhances the formation of high-molecular weight S
Autor:
Guido Capitani, Christophe Briand, Stephanie Papin, Christian Grütter, Peer R. E. Mittl, Jürg Tschopp, Markus G. Grütter
Publikováno v:
FEBS Letters. (1):99-106
We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded a
Publikováno v:
FEBS Letters. (14):2003-2015
Transforming growth factor beta (TGFβ) is a multipotent cytokine that is sequestered in the extracellular matrix (ECM) through interactions with a number of ECM proteins. The ECM serves to concentrate latent TGFβ at sites of intended function, to i
Autor:
Ryoji Kobayashi, Maki Takata, Masaaki Tokuda, Seiko Shimamoto, Fuminori Yamaguchi, Hiroshi Tokumitsu
Publikováno v:
FEBS Letters. (22):4517-4523
Although the precise intracellular roles of S100 proteins are not fully understood, these proteins are thought to be involved in Ca2+-dependent diverse signal transduction pathways. In this report, we identified importin α as a novel target of S100A
Autor:
Tadanobu Takahashi, Mami Maruyama, Makoto Kiso, Asako Hashimoto, Yoshihiro Kawaoka, Hideharu Ishida, Yasuo Suzuki, Takashi Suzuki
Publikováno v:
FEBS Letters. (19):3171-3174
To identify a determinant of human H3 hemagglutinin (HA) amino acid residues linked to the recognition of molecular species of sialic acid, we generated six mutant viruses possessing either the wild-type HA gene from A/Memphis/1/71 (H3N2) or a geneti
Publikováno v:
FEBS Letters. (1):61-64
Proteins of the 14-3-3 family can associate with and/or modulate the activities of a variety of proteins, such as protooncogene and oncogene products, Cdc25 phosphatases and phosphatidylinositol 3-kinase, and thus are implicated in regulation of sign
Autor:
Tingjian Chen, Floyd E. Romesberg
Publikováno v:
FEBS Letters. (2):219-229
Polymerases evolved in nature to synthesize DNA and RNA, and they underlie the storage and flow of genetic information in all cells. The availability of these enzymes for use at the bench has driven a revolution in biotechnology and medicinal researc