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Autor:
Jyrki P. Kukkonen, Lisa Johansson, Johnny Näsman, Jaana Putula, Laura Korhonen, Runar Ra, Pauli M. Turunen
Publikováno v:
FEBS Letters. (9):1368-1374
We wanted to analyze the basis for the distinction between OX(1) and OX(2) orexin receptors by the known agonists, orexin-A, orexin-B and Ala(11), D-Leu(15)-orexin-B, of which the latter two show some selectivity for OX(2). For this, chimaeric OX(1)/
Autor:
Vadim I. Agol, George A. Belov, Markus Kalkum, Nina V. Chichkova, Andrey B. Vartapetian, Alexandra G. Evstafieva, Alexey A. Bogdanov
Publikováno v:
FEBS Letters. (2-3):150-154
We observed fragmentation of an essential proliferation-related human nuclear protein prothymosin alpha in the course of apoptosis induced by various stimuli. Prothymosin alpha cleavage occurred at the DDVD(99) motif. In vitro, prothymosin alpha coul
Publikováno v:
FEBS Letters. (25):5009-5016
Desensitization of the cannabinoid CB1 receptor is mediated by the interaction with arrestin. In this study, we report the structural changes of a synthetic diphosphorylated peptide corresponding to residues 419–439 of the CB1 C-terminus upon bindi
Autor:
Hansjörg Teschemacher, Volker Höllt, Bernd Bonnekoh, Melany Jayasinghe, Harald Gollnick, Helga Tischmeyer, Peter Mayer
Publikováno v:
FEBS Letters. (2-3):156-160
δ Opioid receptors were identified in human melanomas by RT-PCR and radioligand binding. In all tumors an additional PCR amplificate was detected in which 144 bp within the third exon were deleted. This fragment corresponded to the third cytoplasmic
Publikováno v:
FEBS Letters. (1-3):207-210
The 14-3-3 proteins are known to interact with a number of proteins involved in the regulation of cell signaling. Here, we describe an association of 14-3-3ζ with the epidermal growth factor receptor (EGFR) that is rapidly induced by EGF. The 1028-E
Publikováno v:
FEBS Letters. (2-3):248-252
beta-Amyloid precursor protein (APP) is a type I transmembrane protein. Its cleavages by beta- and gamma-secretases yield beta-amyloid, which is the main constituent of senile plaques in Alzheimer's disease (AD). In apoptotic cells and AD brains, APP
Publikováno v:
FEBS Letters
FEBS Letters, Wiley, 2003, pp.299-303. ⟨10.1016/S0014-5793(03)01033-0 ⟩
FEBS Letters, Wiley, 2003, pp.299-303. ⟨10.1016/S0014-5793(03)01033-0⟩
FEBS Letters, Wiley, 2003, pp.303
FEBS Letters, Wiley, 2003, pp.299-303. ⟨10.1016/S0014-5793(03)01033-0 ⟩
FEBS Letters, Wiley, 2003, pp.299-303. ⟨10.1016/S0014-5793(03)01033-0⟩
FEBS Letters, Wiley, 2003, pp.303
International audience; Ileal bile acid‐binding protein (I‐BABP) is a 14 kDa cytosolic protein which binds bile acids with a high affinity. It is thought to be implicated in the enterohepatic circulation of bile acids and, hence, in cholesterol h
Autor:
Keiko Naruto, Koji Tomoo, Taizo Taniguchi, Ryouhei Okuda, Toshimasa Ishida, Yasuko In, Katsuhiko Minoura
Publikováno v:
FEBS Letters. (19):4233-4236
Investigation of the mechanism of tau polymerization is indispensable for finding inhibitory conditions or identifying compounds preventing the formation of paired helical filament or oligomers. Tau contains a microtubule-binding domain consisting of
Autor:
Ryoji Kobayashi, Maki Takata, Masaaki Tokuda, Seiko Shimamoto, Fuminori Yamaguchi, Hiroshi Tokumitsu
Publikováno v:
FEBS Letters. (22):4517-4523
Although the precise intracellular roles of S100 proteins are not fully understood, these proteins are thought to be involved in Ca2+-dependent diverse signal transduction pathways. In this report, we identified importin α as a novel target of S100A
Publikováno v:
FEBS Letters. (1):61-64
Proteins of the 14-3-3 family can associate with and/or modulate the activities of a variety of proteins, such as protooncogene and oncogene products, Cdc25 phosphatases and phosphatidylinositol 3-kinase, and thus are implicated in regulation of sign