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Publikováno v:
Genes & Diseases. 10:542-553
Periodontitis is an oral chronic inflammatory disease. Inhibiting tissue destruction and promoting tissue regeneration are important means for the treatment of periodontitis. Metformin not only has hypoglycemic effect but also has anti-inflammatory e
Autor:
Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V. Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pederson, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri
Publikováno v:
JACC Basic Transl Sci
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010
ObjectivesDetermine the role of apolipoprotein M (ApoM) in anthracycline (Dox) cardiotoxicity.BackgroundApoM binds the cardioprotective sphingolipid sphingosine-1-phosphate (S1P). Circulating ApoM is inversely associated with mortality in human heart
Autor:
Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Bishnu Prasad Behera, Kewal Kumar Mahapatra, Shankargouda Patil, Amruta Singh, Rohan Dhiman, Srimanta Patra, Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra
Publikováno v:
Seminars in Cancer Biology. 83:399-412
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-
Autor:
Yu-Wen Lin, Jehng-Kang Wang, Michael D. Johnson, Yi-Ying Wu, Hou-Ping Sytwo, Chen-Yong Lin, Kacy Yang, Yi-Lin Chiu, Robert B. Barndt, Amy Cheng, Khee-Siang Chan
Publikováno v:
Genes & Diseases. 9:1049-1061
The integral membrane, Kunitz-type serine protease inhibitors HAI-1 and HAI-2 can suppress the proteolytic activity of the type 2 transmembrane serine protease matriptase with high specificity and potency. High levels of extracellular matriptase prot
Autor:
Jian-Feng Liu, You Jin, Jian-Guo Chen, Lan Ni, Zhuang-Li Hu, Cong Ma, Jia-Jing Lu, Shi-Ge Xue, Yi Luo, Hui-Ling Zheng, Fang Wang, Wen-Long Xie, Hou-Hong Li
Publikováno v:
Biological Psychiatry. 91:593-603
Background Depression is a common psychiatric disorder associated with the defects in GABAergic neurotransmission. α-Dystroglycan (α-DG), a cell adhesion molecule known to be essential for skeletal muscle integrity, is also present at inhibitory sy
Autor:
Monique Verhaegen, Arul M. Chinnaiyan, Julia VanGoor, Drew Pratt, Doris Mangelberger, Xuhong Cao, Fengyun Su, Andrzej A. Dlugosz, Jean C. Tien, Josh N. Vo, Jae Eun Choi, Paul W. Harms, Vincent T. Ma, Saravana M. Dhanasekaran
Publikováno v:
J Invest Dermatol
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma that is classified as Merkel cell polyomavirus (MCPyV)-positive or virus-negative. Epigenetic changes, such as DNA methylation, can alter gene expression and influence ca
Autor:
Tales Vicari Pascini, Thiago Luiz Alves e Silva, Yeong Je Jeong, Zarna Rajeshkumar Pala, Joel Vega-Rodríguez, Brendan Sweeney, Medard Ernest
Publikováno v:
Trends Parasitol
Plasmodium and other vector-borne pathogens have evolved mechanisms to hijack the mammalian fibrinolytic system to facilitate infection of the human host and the invertebrate vector. Plasmin, the effector protease of fibrinolysis, maintains homeostas
Autor:
Minka Zivkovic, Mark Roest, Thomas Renné, Chantal C. Clark, Arjan D. Barendrecht, Coen Maas, Hinde El Otmani, Simone M. Smits, Wariya Sanrattana, Nadine D van Kleef, Steven de Maat
Publikováno v:
Journal of Thrombosis and Haemostasis. 20:353-365
BACKGROUND Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell contains resting platelets. This core is inaccessible to plasma proteins. We produced a fusion pro
Publikováno v:
Fungal Biology. 126:1-10
Penicillium expansum is the causal agent of blue mold in harvested fruits and vegetables during storage and distribution, causing serious economic loss. In this study we seek the action modes of bifonazole against this pathogen. Bifonazole exhibited
Publikováno v:
Neuroscience. 481:99-110
The widespread application of ionizing radiation in industrial and medical fields leads to the increased brain exposure to X-rays. Radiation brain injury (RBI) seriously affects health of patients by causing cognitive dysfunction and neuroinflammatio