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Autor:
Amy Weise, Maureen G. Conlan, Steven Troy, Patricia LoRusso, Miriam Annett, Cynthia X. Ma, Neelima Vidula, Erika Hamilton, Ziyang Yu, Rebecca G. Bagley
Publikováno v:
Clinical Breast Cancer. 22:67-77
Introduction/Background This first-in-human, phase 1 study aimed to characterize the safety, tolerability, maximum tolerated dose (MTD), pharmacokinetic (PK) profile, and antitumor activity of RAD140, an oral selective androgen receptor (AR) modulato
Autor:
Yoshiaki Murakami, Shingo Seo, Hiroyuki Otsuka, Yasushi Hashimoto, Naru Kondo, Shinya Takahashi, Takeshi Sudo, Kenjiro Okada, Tatsuaki Sumiyoshi, Kenichiro Uemura
Publikováno v:
European Journal of Cancer. 159:215-223
Background The prognosis of patients with borderline resectable pancreatic cancer with arterial contact (BRPC-A) is extremely poor, and effective preoperative treatment is indispensable. We evaluated the clinical efficacy and safety of neoadjuvant ch
Autor:
Philippe Ruszniewski, Tahir Shah, Ulrich Frank Pape, Aude Houchard, Marianne Pavel, C. Lombard-Bohas, Xuan-Mai Truong Thanh, Francesco Panzuto, Ivan Borbath, Jarosław B. Ćwikła, Jaume Capdevila
Publikováno v:
Scientia
European journal of cancer (Oxford, England : 1990), Vol. 157, no.157, p. 403-414 (2021)
European journal of cancer (Oxford, England : 1990), Vol. 157, no.157, p. 403-414 (2021)
Lanreotide; Progression-free survival; Somatostatin Lanreótido; Supervivencia libre de progresión; Somatostatina Lanreòtid; Supervivència lliure de progressió; Somatostatina Introduction This prospective, single-arm, phase 2 study assessed the e
Autor:
In Gyu Hwang, Sang-Cheol Lee, Yaewon Yang, Sung Yong Oh, Sang-Gon Park, So Yeon Jeon, Dae Young Zang, Jung Hun Kang, Jun Ho Ji, Hyun Woo Lee, Woo Kyun Bae, Sun Jin Sym, Se-Il Go, Joung Soon Jang, Jung Hoon Kim
Publikováno v:
European Journal of Cancer. 157:21-30
Background The efficacy of modified FOLFIRINOX (mFOLFIRINOX) as a second-line chemotherapy treatment for metastatic pancreatic adenocarcinoma (mPAC), remains unclear. This multi-center randomised phase III trial aimed to elucidate the efficacy of mFO
Autor:
Yohei Masugi, Hirokazu Matsushita, Hiroaki Kuroda, Yusuke Takahashi, Takao Shigenobu, Ryutaro Hanawa, Atsushi Tajima
Publikováno v:
Clinical Lung Cancer. 22:e820-e828
Histologic subtyping offers some prognostic value in lung adenocarcinoma. We thus hypothesized that histologic subtypes may be useful for risk stratification of brain metastasis (BM). In this study, we aimed to investigate the impact of histologic su
Autor:
Norihiro Kokudo, Hiraku Yodono, Naoki Yamanaka, Seiji Kawasaki, Tadatoshi Takayama, Shinji Tanaka, Masashi Fujii, Eigo Otsuji, Yutaka Matsuyama, Masamichi Moriguchi, Hidemori Sakamoto, Osamu Aramaki, Yo Sasaki, Keiichi Kubota
Publikováno v:
European Journal of Cancer. 157:373-382
Background Transarterial chemoembolisation (TACE) is a treatment option for hepatocellular carcinoma (HCC), but the optimum agent for TACE remains unclear. We compared the efficacy of TACE with cisplatin versus with epirubicin in patients with unrese
Autor:
Hao Wang, Qiaohua Xie, Cong Cheng, Peng Wang, Liping Lei, ShouZi Hu, Guofang Liu, Huabang Zhou, YouShun Liu, Heping Hu
Publikováno v:
Bulletin du Cancer. 108:931-939
Summary Background Both modified Child-Pugh (MCP) and Albumin-bilirubin (ALBI) grade were reported that simpler, more objective and evidence-based alternative to the Child-Pugh (CP) class for assessing liver function. Aims To investigate whether the
Autor:
Jean El Cheikh, Iman Abou Dalle, Jeries Kort, Farouk Al Chami, Maya Charafeddine, Haidar El Darsa, Rola El Sayed, Ali Ibrahim, Ali Bazarbachi
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:711-719
Background Intensified immunochemotherapy with rituximab, doxorubicin, cyclophosphamide, vindesine, bleomycin, and prednisone (R-ACVBP) improves outcomes in younger adults with diffuse large B-cell lymphomas (DLBCL) compared with R-CHOP. Due to vinde
Autor:
William R. Drobyski, Nirav N. Shah, Walter L. Longo, Timothy S. Fenske, Bicky Thapa, Anita D'Souza, Sergey Tarima, Muhammad Bilal Abid, Saurabh Chhabra, Huaying Dong, Parameswaran Hari, Binod Dhakal, Mehdi Hamadani
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 21:e775-e781
Engraftment syndrome (ES) after autologous hematopoietic cell transplantation (AHCT) in multiple myeloma (MM) encompasses a continuum of periengraftment complications characterized by noninfectious fever, rash, diarrhea, and capillary leak features.W
Autor:
Tatyana N. Sokolova, Olga S. Yatsuk, Roman Meerovich, Kirill A. Zagorodnev, Evgeny N. Imyanitov, Maxim M. Kholmatov, Grigoriy A. Yanus, Olga A. Zaitseva, Ekaterina Sh Kuligina, Maria O. Anisimova, Tatiana A. Laidus, Aleksandr S. Martianov, Aleksandr A. Romanko
Publikováno v:
Cancer Genetics. :165-178
Purpose This study aimed to investigate factors, which influence the content of circulating tumor DNA (ctDNA). Methods 398 serial plasma samples were collected within 1–7 consecutive days from patients with EGFR-mutated lung cancer (n = 13), RAS/RA