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Publikováno v:
International Journal of Biological Macromolecules
SARS-CoV-2 nucleocapsid (N) protein undergoes RNA-induced phase separation (LLPS) and sequesters the host key stress granule (SG) proteins, Ras-GTPase-activating protein SH3-domain-binding protein 1 and 2 (G3BP1 and G3BP2) to inhibit SG formation. Th
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Publikováno v:
Journal of Controlled Release
Due to the rapid changes that have occurred in the field of drug discovery and the recent developments in the early 21st century, the role of drug delivery systems (DDS) has become increasingly more important. For the past 20 years, our laboratory ha
Autor:
Yohei Kawakami, Laura J. Niedernhofer, Paul D. Robbins, Tomoyuki Matsumoto, Masahiro Kurosaka, Xiaodong Mu, Johnny Huard, Ryosuke Kuroda, William S. Hambright, Koji Takayama, Takashi Yurube, Aiping Lu, Freddie H. Fu, James H. Cummins
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Aging-related loss of adult stem cell function contributes to impaired tissue regeneration. Mice deficient in zinc metalloproteinase STE24 (Zmpste24−/−) exhibit premature age-related musculoskeletal pathologies similar to those observed in childr
Publikováno v:
International Journal of Biological Macromolecules
The recent emergence of the novel coronavirus (SARS-CoV-2) has resulted in a devastating pandemic with global concern. However, to date, there are no regimens to prevent and treat SARS-CoV-2 virus. There is an urgent need to identify novel leads with
SARS-CoV-2 infection in patients with primary mitochondrial diseases: Features and outcomes in Italy
Autor:
Anna Ardissone, Serenella Servidei, Olimpia Musumeci, Valerio Carelli, Chiara La Morgia, Maria Lucia Valentino, Michelangelo Mancuso, Caterina Garone, Guido Primiano, Costanza Lamperti, Gabriele Siciliano, Antonio Toscano, Elena Procopio
Publikováno v:
Mitochondrion
Patients with mitochondrial diseases, who usually manifest a multisystem disease, are considered potentially at-risk for a severe coronavirus disease 2019 (COVID-19). The objective of this study is to analyze the clinical features, prognosis and outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d85345e9516802279ca093deccf71b
http://hdl.handle.net/11570/3203995
http://hdl.handle.net/11570/3203995
Autor:
Lorenzo Botta, Fabiola Ciccosanti, Francesca Colavita, Gian Maria Fimia, Fabrizio Manetti, Martina Di Rienzo, Concetta Castilletti, Alessandra Romagnoli, Giuseppe Ippolito, Annalaura Brai, Giulia Refolo, Mauro Piacentini, Maria Rosaria Capobianchi, Chiara Agrati
Publikováno v:
Antiviral Research
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b3ebf478516ed3ffc9ca4461d86b2
http://hdl.handle.net/11573/1572508
http://hdl.handle.net/11573/1572508
Autor:
Chiara Vianello, Paolo Mocellin, Rossella Pozzi, Giuseppe Maschio, Fernanda Strozzi, Bruno Fabiano, Elisa Cimetta, Flavio Manenti
Publikováno v:
Biochemical and Biophysical Research Communications
The ongoing COVID-19 epidemic highlights the need for effective tools capable of predicting the onset of infection outbreaks at their early stages. The tracing of confirmed cases and the prediction of the local dynamics of contagion through early ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a725f32949ab9462a51c6455060b6cd0
http://hdl.handle.net/11577/3364231
http://hdl.handle.net/11577/3364231
Autor:
Nikos K. Karamanos, Maurizio Onisto, Marco Franchi, Eirini Riti, Zoi Piperigkou, Valentina Masola
Publikováno v:
Matrix Biology Plus, Vol 6, Iss, Pp 100026-(2020)
Matrix Biology Plus
Matrix Biology Plus
Cancer cell invasion into the surrounding extracellular matrix (ECM) takes place when cell-cell junctions are disrupted upon epithelial-to-mesenchymal transition (EMT). Both cancer cell-stroma and cell-cell crosstalk are essential to support the cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26776a5aa1dcdff99a065ddaa8f649c
http://hdl.handle.net/11577/3352417
http://hdl.handle.net/11577/3352417
Autor:
Isabel Rivera, Sunyoung Hwang, Megan C. King, Maria I. Lioudyno, Jorge Busciglio, Jessica F. Williams, Maja Kneissig, Eduardo M. Torres, Pablo Helguera, Zuzana Storchova
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 29, Iss 8, Pp 2473-2488.e5 (2019)
Cell reports
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cell Reports, Vol 29, Iss 8, Pp 2473-2488.e5 (2019)
Cell reports
SUMMARY An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6bc6aa08cd1366053f252f8529913b
https://linkinghub.elsevier.com/retrieve/pii/S2211124719313737
https://linkinghub.elsevier.com/retrieve/pii/S2211124719313737