Zobrazeno 1 - 10
of 40
pro vyhledávání: ''
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Autor:
Lorenzo Botta, Fabiola Ciccosanti, Francesca Colavita, Gian Maria Fimia, Fabrizio Manetti, Martina Di Rienzo, Concetta Castilletti, Alessandra Romagnoli, Giuseppe Ippolito, Annalaura Brai, Giulia Refolo, Mauro Piacentini, Maria Rosaria Capobianchi, Chiara Agrati
Publikováno v:
Antiviral Research
COVID-19 is currently a highly pressing health threat and therapeutic strategies to mitigate the infection impact are urgently needed. Characterization of the SARS-CoV-2 interactome in infected cells may represent a powerful tool to identify cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217b3ebf478516ed3ffc9ca4461d86b2
http://hdl.handle.net/11573/1572508
http://hdl.handle.net/11573/1572508
Autor:
Honglin Luo
Publikováno v:
Current Opinion in Virology
Highlights • Many viruses have evolved to utilize the host UPS for their own benefit. • Viruses subvert the UPS to maintain optimal level/function of viral proteins. • Viruses exploit the UPS to degrade host proteins which impede viral growth.
Cholesterol-rich lipid rafts play an important role in the Cyprinid herpesvirus 3 replication cycle☆
Autor:
Reiner Ulrich, Mikolaj Adamek, Marcus J. Proepsting, Hassan Y. Naim, Dieter Steinhagen, Graham Brogden
Publikováno v:
Veterinary Microbiology
Highlights • Sequestration of cholesterol from the cell membrane inhibits CyHV-3 entry. • CyHV-3 egress requires cholesterol. • Lipid composition of the CyHV-3 envelope is similar to that of CCB lipid rafts.
The Cyprinus herpesvirus 3 (CyH
The Cyprinus herpesvirus 3 (CyH
Publikováno v:
Current Opinion in Virology
Current Opinion in Virology; Vol 2
Current Opinion in Virology; Vol 2
Highlights ► Experimental methods to study virus–host interactomes including mammalian validation systems. ► Yeast-two-hybrid (Y2H) as classical high-throughput method for protein–protein interaction analysis. ► Cellular antiviral drug targ
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (6-7):939-944
Coupled rat heart mitochondria produce externally hydrogen peroxide at the rates which correspond to about 0.8 and 0.3% of the total oxygen consumption at State 4 with succinate and glutamate plus malate as the respiratory substrates, respectively. S
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (10):1198-1205
Galectin-3, a s-galactoside-binding lectin, is found in cellular and extracellular location of the cell and has pleiotropic biological functions such as cell growth, cell adhesion and cell-cell interaction. It may exhibit anti- or pro-apoptotic activ
Publikováno v:
Biochim Biophys Acta
p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PAK1 also promotes CRC survival via up-regulation of hypoxia-inducible factor 1α (HIF-1α), a key player in cancer survi
Autor:
Richard M. Epand, Gowtham Jayakumaran, Matthew K. Topham, Januvi Jegatheswaran, Arpita Gantayet
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. (4):1050-1053
Mammalian diacylglycerol kinases are a family of enzymes that catalyze the phosphorylation of diacylglycerol to produce phosphatidic acid. The extent of interaction of these enzymes with monoacylglycerols is the focus of the present study. Because of
Autor:
Li Na Wei, Hong Yiou Lin, Angel Y.F. Kam, Ping-Yee Law, Horace H. Loh, Yadav Wagley, Cheol Kyu Hwang
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (6):1476-1488
Despite its potential side effects of addiction, tolerance and withdrawal symptoms, morphine is widely used for reducing moderate and severe pain. Previous studies have shown that the analgesic effect of morphine depends on mu opioid receptor (MOR) e