Zobrazeno 1 - 10
of 145
pro vyhledávání: ''
Autor:
Keith W. Caldecott, Zhengping Shao, Kouji Hirota, Annie A. Demin, Shan Zha, Jan Brazina, Hana Hanzlikova, Shunichi Takeda, Marek Adamowicz, Masataka Tsuda, William Gittens, Richard Hailstone, Ilona Kalasova, Hiroyuki Sasanuma
Publikováno v:
Molecular Cell
Summary Mammalian DNA base excision repair (BER) is accelerated by poly(ADP-ribose) polymerases (PARPs) and the scaffold protein XRCC1. PARPs are sensors that detect single-strand break intermediates, but the critical role of XRCC1 during BER is unkn
Publikováno v:
Journal of Controlled Release
Due to the rapid changes that have occurred in the field of drug discovery and the recent developments in the early 21st century, the role of drug delivery systems (DDS) has become increasingly more important. For the past 20 years, our laboratory ha
Publikováno v:
International Journal of Biological Macromolecules
The recent emergence of the novel coronavirus (SARS-CoV-2) has resulted in a devastating pandemic with global concern. However, to date, there are no regimens to prevent and treat SARS-CoV-2 virus. There is an urgent need to identify novel leads with
Publikováno v:
Virus Research
The open reading frame 8 (orf8) is an accessory protein of SARS-CoV-2. It has 121 amino acids with two genotypes, orf8L and orf8S. In this study, we overexpressed the orf8L and orf8S of SARS-CoV-2 as well as the orf8b of SARS-CoV to investigate their
Publikováno v:
Current Opinion in Virology
Current Opinion in Virology; Vol 2
Current Opinion in Virology; Vol 2
Highlights ► Experimental methods to study virus–host interactomes including mammalian validation systems. ► Yeast-two-hybrid (Y2H) as classical high-throughput method for protein–protein interaction analysis. ► Cellular antiviral drug targ
Autor:
Brian P. Ashburner, Eric T. Cole, Amanda Korchnak, Widian F. Abi Saab, Yu Zhan, Deborah N. Chadee
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (12):1811-1818
Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase (MAP3K) that activates multiple MAPK signaling pathways. Nuclear factor kappa B (NF-kappaB) is a transcription factor that has important functions in inflammation, immu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. (12):2745-2756
N-Methyl-d-aspartate (NMDA) receptors are major glutamatergic receptors involved in most excitatory neurotransmission in the brain. The transcriptional regulation of NMDA receptors is not fully understood. Previously, we found that the GluN1 and GluN
Autor:
Gail D. Zeevalk, Alpa H. Gautam
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (7):819-828
Loss of dopamine (DA) homeostasis may be a contributing factor to cell damage in Parkinson's disease (PD). Past studies showing deleterious effects of DA on mitochondrial function, however, have been inconsistent raising questions about mitochondria
Autor:
Rodney L. Burton, Klaus Schulten, Antony R. Crofts, Doreen Victoria, Charles M. Wilson, Christopher B. Harrison, Sangjin Hong
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. (11-12):1362-1377
1. Recent results suggest that the major flux is carried by a monomeric function, not by an intermonomer electron flow. 2. The bifurcated reaction at the Qo-site involves sequential partial processes, - a rate limiting first electron transfer generat
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. (6):862-874
The objective of this study was to elucidate the effect of partial reduction of the mitochondrial fission protein, dynamin-related protein 1 (Drp1) on mitochondrial activity and synaptic viability. Recent knockout studies of Drp1 revealed that homozy