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Publikováno v:
Learning & Memory. 30:96-100
The hippocampus supports distinctive encoding, enabling discrimination of perceptions from similar memories. Here, an experimental and individual differences approach examined the role of encoding quality in the classification of similar lures. An ob
Publikováno v:
Genome Research. 33:479-495
High-throughput methods such as RNA-seq, ChIP-seq, and ATAC-seq have well-established guidelines, commercial kits, and analysis pipelines that enable consistency and wider adoption for understanding genome function and regulation. STARR-seq, a popula
Publikováno v:
Genome Research. 33:525-540
Small nucleolar RNAs (snoRNAs) are structured noncoding RNAs present in multiple copies within eukaryotic genomes. snoRNAs guide chemical modifications on their target RNA and regulate processes like ribosome assembly and splicing. Most human snoRNAs
Autor:
Yuan Lu, Edward Rice, Kang Du, Susanne Kneitz, Magali Naville, Corentin Dechaud, Jean-Nicolas Volff, Mikki Boswell, William Boswell, LaDeana Hillier, Chad Tomlinson, Kremitzki Milin, Ronald B. Walter, Manfred Schartl, Wesley C. Warren
Publikováno v:
Genome Research. 33:557-571
Because of diverged adaptative phenotypes, fish species of the genusXiphophorushave contributed to a wide range of research for a century. ExistingXiphophorusgenome assemblies are not at the chromosomal level and are prone to sequence gaps, thus hind
Publikováno v:
Genome Research. 33:572-586
Epigenetic modifications undergo drastic erasure and reestablishment after fertilization. This reprogramming is required for proper embryonic development and cell differentiation. In mammals, some histone modifications are not completely reprogrammed
Publikováno v:
Genome Research. 33:658-671
The zebrafish telencephalon is composed of highly specialized subregions that regulate complex behaviors such as learning, memory, and social interactions. The transcriptional signatures of the neuronal cell types in the telencephalon and the timelin
Autor:
Mariano F. Zacarías-Fluck, Daniel Massó-Vallés, Fabio Giuntini, Íñigo González-Larreategui, Jastrinjan Kaur, Sílvia Casacuberta-Serra, Toni Jauset, Sandra Martínez-Martín, Génesis Martín-Fernández, Erika Serrano del Pozo, Laia Foradada, Judit Grueso, Lara Nonell, Marie-Eve Beaulieu, Jonathan R. Whitfield, Laura Soucek
Publikováno v:
Genes & Development. 37:303-320
MYC's key role in oncogenesis and tumor progression has long been established for most human cancers. In melanoma, its deregulated activity by amplification of 8q24 chromosome or by upstream signaling coming from activating mutations in the RAS/RAF/M
Publikováno v:
Learning & Memory. 30:85-95
Long-term memory (LTM) formation is dependent on neurochemical changes that guarantee that a recently formed memory (short-term memory [STM]) remains in the specific neural circuitry via the consolidation process. The persistence of recognition memor
Publikováno v:
Genome Research. 33:612-621
Rare species are vital members of a microbial community, but retrieving their genomes is difficult because of their low abundance. The ReadUntil (RU) approach allows nanopore devices to sequence specific DNA molecules selectively in real time, which
Autor:
Yongkang Long, Bin Zhang, Shuye Tian, Jia Jia Chan, Juexiao Zhou, Zhongxiao Li, Yisheng Li, Zheng An, Xingyu Liao, Yu Wang, Shiwei Sun, Ying Xu, Yvonne Tay, Wei Chen, Xin Gao
Publikováno v:
Genome Research. 33:644-657
Alternative polyadenylation (APA) enables a gene to generate multiple transcripts with different 3′ ends, which is dynamic across different cell types or conditions. Many computational methods have been developed to characterize sample-specific APA