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Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Autor:
Rodrigo de Oliveira Formiga, Flávia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antônia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Márick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clémence Martin, Pierre-Régis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, André Báfica, Véronique Witko-Sarsat, Fernando Spiller
Publikováno v:
bioRxiv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e80654188358ad8cc60996af3801d8
https://europepmc.org/articles/PMC9641843/
https://europepmc.org/articles/PMC9641843/
Publikováno v:
RNA
Many antibiotics that bind to the ribosome inhibit translation by blocking the movement of tRNAs and mRNA or interfering with ribosome dynamics, which impairs the formation of essential translocation intermediates. Here we show how translocation inhi
Autor:
Yuan Hou, Yadi Zhou, Pengyue Zhang, Jielin Xu, Andrew A. Pieper, Yin Huang, Jeffrey L. Cummings, Feixiong Cheng, Chien-Wei Chiang, Lang Li, Lynn M. Bekris, Justin D. Lathia, James B. Leverenz
Publikováno v:
Genome Res
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targe
Autor:
Taisuke Kamada, Toshimichi Hata
Publikováno v:
Learn Mem
Dopamine plays a critical role in behavioral tasks requiring interval timing (time perception in a seconds-to-minutes range). Although some studies demonstrate the role of dopamine receptors as a controller of the speed of the internal clock, other s
Publikováno v:
Learn Mem
The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear me
Autor:
Eric L. Van Nostrand, Jeanine L. Van Nostrand, En-Ching Luo, Kristina Hellberg, Jingting Yu, Yelena Dayn, Reuben J. Shaw, Alina Dayn, Gene W. Yeo, Maxim N. Shokhirev
Publikováno v:
Genes Dev
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic bene
Antimicrobial stewardship (AMS), the evidence-based use of antimicrobials, is an effective strategy in controlling antimicrobial resistance (AMR) in humans by reducing the irrational use of antimicrobials. Stewardship in children is less studied. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7ce54701ac9f724745dbe21c8176d5
https://doi.org/10.1101/2021.11.30.21267070
https://doi.org/10.1101/2021.11.30.21267070
Autor:
Richard D. Smith, Robert K. Ernst, Giovanna Hernandez, Taylor M Young, Andrew W Hudson, Andrew S. Bray, Muhammad Ammar Zafar
Due to its high transmissibility, Klebsiella pneumoniae (Kpn) is one of the leading causes of nosocomial infections. Here, we studied the biological cost of colistin resistance, an antibiotic of last resort, of this opportunistic pathogen using a mur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f70231130a2a960ddebc819fc09c4a8c
https://doi.org/10.1101/2021.12.01.470879
https://doi.org/10.1101/2021.12.01.470879
BackgroundWe present a multidisciplinary approach to clinical trial design and analysis in a pilot study (NCT02415621) in which evolution-based mathematical models guide patient-specific dosing for Abiraterone treatment in men with castrate resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4621cad95b12b3eeb3e571b112f8283
https://doi.org/10.1101/2021.11.30.21267059
https://doi.org/10.1101/2021.11.30.21267059