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Autor:
Kanella Eliadis, YueYue Hu, Stephanie A. Flowers, Junlone Moy, Elizabeth B. Hirsch, Michael J. Federle, Lori Ellezian, Yasuhiro Kyono
Atypical antipsychotic (AAP) medication is a critical tool for treating symptoms of psychiatric disorders. While AAPs primarily target dopamine (D2) and serotonin (5HT2A and 5HT1A) receptors, they also exhibit intrinsic antimicrobial activity as an o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d14824189c21f62863259f9097c9e63b
https://doi.org/10.1101/2021.11.29.470511
https://doi.org/10.1101/2021.11.29.470511
The present study reports a one-step clean synthesis of carbon dots (CDs) using clove buds and polyvinylpyrrolidone (PVP) as the starting precursor via hydrothermal routes. The adopted technique is facile, reproducible, and cost-effective for the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e90dd26d17673bec699b7adb275e60
https://doi.org/10.1101/2021.11.29.470381
https://doi.org/10.1101/2021.11.29.470381
BackgroundREGN-COV2, a monoclonal antibody cocktail drug against the SARS-COV-2 virus, has proven to be effective in preventing the development of severe COVID-19 and is increasingly being administered in outpatient and home settings. Adverse events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a1f1256dc597bef93350b59ee1681f
https://doi.org/10.1101/2021.11.29.21266623
https://doi.org/10.1101/2021.11.29.21266623
Autor:
Celia D. C. Christie, Abigail Harrison, Varough M. Deyde, R Melbourne-Chambers, Kelly-Ann Maxorinthia Gordon-Johnson, Joshua J. Anzinger, Crista-Lee Shahine Berry
Background and ObjectivesMultisystem inflammatory syndrome of children (MISC) carries a high attributable morbidity. We describe children aged MethodsAll were tested for SARS-CoV-2, infectious disease consultations performed, modified CDC criteria fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d310cb23ef97de591890441ca773dfa
https://doi.org/10.1101/2021.11.26.21266916
https://doi.org/10.1101/2021.11.26.21266916
Autor:
Sara S. Nunes, Xuetao Sun
People with diabetes mellitus (DM) are at an increased risk for myocardial infarction (MI) than age matched people without DM. However, assays for pre-clinical therapy are performed in animal models of ischemia that lack the co-morbid conditions pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7138512d828c48d2d02285b0f380d0
https://doi.org/10.1101/2021.11.27.470203
https://doi.org/10.1101/2021.11.27.470203
Sleep deprivation interferes with long-term memory and cognitive functions by over-activation of phosphodiesterase (PDE) enzymes. PDE4 is a non-redundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus, and is invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41feac27dc744831bd79f00ab8d9d196
https://doi.org/10.1101/2021.11.28.470251
https://doi.org/10.1101/2021.11.28.470251
Autor:
Wojciech Glac, Marek Wiergowski, Maciej M. Jankowski, Artur H. Swiergiel, Paulina Kazmierska-Grebowska, Bogna M. Ignatowska-Jankowska
Modulation of dopamine transmission evokes strong behavioral effects that can be achieved by psychoactive drugs such as haloperidol or cocaine. Cocaine non-specifically increases dopamine transmission by blocking dopamine active transporter (DAT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4159dd31c820f9ad18acff746c6e0a9
https://doi.org/10.1101/2021.11.28.470229
https://doi.org/10.1101/2021.11.28.470229
Striatal adenosine A1receptor (A1R) activation can inhibit dopamine release. A1Rs on other striatal neurons are activated by an adenosine tone that is limited by equilibrative nucleoside transporter 1 (ENT1) that is enriched on astrocytes and is etha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bee11b54382993d5e8a8c5dad62fd9
https://doi.org/10.1101/2021.11.27.470186
https://doi.org/10.1101/2021.11.27.470186
Nociceptive signals interact with various regions of the brain, including those involved in physical sensation, reward, cognition, and emotion. Emerging evidence points to a role of nociception in the modulation of the mesolimbic reward system. The m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::254b2754e4ab99df3af532f9f4331bae
https://doi.org/10.1101/2021.11.25.470073
https://doi.org/10.1101/2021.11.25.470073
Autor:
Alba Redin Alonso, Imran Nisar, Betuel Sigaúque, Kate Mellor, Shaper Mirza, Lesley McGee, Hui Wang, Sophie Belman, Rebecca Ford, Gail L Rodgers, Paulina A. Hawkins, Rebecca A. Gladstone, Jennifer E. Cornick, Anne von Gottberg, Emmanuelle Varon, Balaji Veeraraghavan, Robert M. Cohen, Philip E. Carter, Ron Dagan, Stephanie W. Lo, Anna Skoczynska, Sadia Shakoor, Stephen K. Obaro, Martin Antonio, Godfrey Bigogo, Deborah Lehmann, Rama Kandasamy, Andrew J. Pollard, Stephen D. Bentley, Samir K. Saha, Jennifer C. Moïsi, K L Ravikumar, Paul Turner, Carmen Munoz Almagro, Brenda Kwambana-Adams, Keith P. Klugman, Robert F. Breiman, Narender Kumar, Naima Elmdaghri
SummaryBackgroundPneumococcal Conjugate Vaccine (PCV) which targets up to 13 serotypes of Streptococcus pneumoniae is very effective at reducing disease in young children; however, rapid increases in replacement with non-PCV serotypes remains a conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17aa21404852d6815a25b2d37219de1c
https://doi.org/10.1101/2021.11.24.21266813
https://doi.org/10.1101/2021.11.24.21266813