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Autor:
Taisuke Kamada, Toshimichi Hata
Publikováno v:
Learn Mem
Dopamine plays a critical role in behavioral tasks requiring interval timing (time perception in a seconds-to-minutes range). Although some studies demonstrate the role of dopamine receptors as a controller of the speed of the internal clock, other s
Antimicrobial stewardship (AMS), the evidence-based use of antimicrobials, is an effective strategy in controlling antimicrobial resistance (AMR) in humans by reducing the irrational use of antimicrobials. Stewardship in children is less studied. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b7ce54701ac9f724745dbe21c8176d5
https://doi.org/10.1101/2021.11.30.21267070
https://doi.org/10.1101/2021.11.30.21267070
BackgroundWe present a multidisciplinary approach to clinical trial design and analysis in a pilot study (NCT02415621) in which evolution-based mathematical models guide patient-specific dosing for Abiraterone treatment in men with castrate resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4621cad95b12b3eeb3e571b112f8283
https://doi.org/10.1101/2021.11.30.21267059
https://doi.org/10.1101/2021.11.30.21267059
Autor:
Joel H. Vazquez, Stephanie D. Byrum, Hartmut Jaeschke, D. Keith Williams, Samuel G. Mackintosh, Mitchell R. McGill, William E. Lee, Stefanie Kennon-McGill, Jonathan A. Dranoff
Better biomarkers to predict death early in acute liver failure (ALF) are needed. To that end, we obtained early (study day 1) and later (day 3) serum samples from transplant-free survivors (n=28) and non-survivors (n=30) of acetaminophen (APAP)-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d993657aa0b3ce5df856233553bcd156
https://doi.org/10.1101/2021.11.30.21266453
https://doi.org/10.1101/2021.11.30.21266453
Autor:
Christian Burri, Babatunde Akano, Christian Lengeler, Elizabeth Omoluabi, Jean Okitawutshu, Nina C. Brunner, Gloria Tumukunde, Phyllis Awor, Ocheche Yusuf, Joseph Kimera, Manuel W Hetzel, Jean-Claude Kalenga, Kazeem Ayodeji, Irene Angiro, Charles Okon, James Okuma, Antoinette Tshefu, Tristan T. Lee, Theodoor Visser, Aita Signorell, Proscovia Athieno, Harriet G. Napier, Nadja Cereghetti, Valentina Buj, Giulia Delvento, Mark Lambiris
BackgroundAppropriate clinical management of severe malaria is critical to avert morbidity and death. Recommended treatment consists of an injectable antimalarial followed by a full course of oral artemisinin-based combination therapy (ACT). Children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5048001edcb16fb53a41dd1b85bec9da
https://doi.org/10.1101/2021.11.26.21266917
https://doi.org/10.1101/2021.11.26.21266917
BackgroundREGN-COV2, a monoclonal antibody cocktail drug against the SARS-COV-2 virus, has proven to be effective in preventing the development of severe COVID-19 and is increasingly being administered in outpatient and home settings. Adverse events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a1f1256dc597bef93350b59ee1681f
https://doi.org/10.1101/2021.11.29.21266623
https://doi.org/10.1101/2021.11.29.21266623
Autor:
Celia D. C. Christie, Abigail Harrison, Varough M. Deyde, R Melbourne-Chambers, Kelly-Ann Maxorinthia Gordon-Johnson, Joshua J. Anzinger, Crista-Lee Shahine Berry
Background and ObjectivesMultisystem inflammatory syndrome of children (MISC) carries a high attributable morbidity. We describe children aged MethodsAll were tested for SARS-CoV-2, infectious disease consultations performed, modified CDC criteria fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d310cb23ef97de591890441ca773dfa
https://doi.org/10.1101/2021.11.26.21266916
https://doi.org/10.1101/2021.11.26.21266916
Autor:
Sara S. Nunes, Xuetao Sun
People with diabetes mellitus (DM) are at an increased risk for myocardial infarction (MI) than age matched people without DM. However, assays for pre-clinical therapy are performed in animal models of ischemia that lack the co-morbid conditions pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa7138512d828c48d2d02285b0f380d0
https://doi.org/10.1101/2021.11.27.470203
https://doi.org/10.1101/2021.11.27.470203
Sleep deprivation interferes with long-term memory and cognitive functions by over-activation of phosphodiesterase (PDE) enzymes. PDE4 is a non-redundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus, and is invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41feac27dc744831bd79f00ab8d9d196
https://doi.org/10.1101/2021.11.28.470251
https://doi.org/10.1101/2021.11.28.470251
Autor:
Muhammad Asif Gul, Farooq Mohyud Din Chaudhary, Shehryar Kanju, Qasim Umar, Rizwan Hameed, Dure Shahwar
IntroductionHepatitis C has gradually become endemic in Pakistan, with infectivity rates one of the highest in the world. The emergence of direct acting antivirals (DAAs) has become a ray of sunshine in eradicating this menace from this region. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dd7d5e5ac7f500fde0fb35920f558c
https://doi.org/10.1101/2021.11.23.21266653
https://doi.org/10.1101/2021.11.23.21266653