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Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Autor:
Rodrigo de Oliveira Formiga, Flávia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antônia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Márick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clémence Martin, Pierre-Régis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, André Báfica, Véronique Witko-Sarsat, Fernando Spiller
Publikováno v:
bioRxiv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e80654188358ad8cc60996af3801d8
https://europepmc.org/articles/PMC9641843/
https://europepmc.org/articles/PMC9641843/
BackgroundWe present a multidisciplinary approach to clinical trial design and analysis in a pilot study (NCT02415621) in which evolution-based mathematical models guide patient-specific dosing for Abiraterone treatment in men with castrate resistant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4621cad95b12b3eeb3e571b112f8283
https://doi.org/10.1101/2021.11.30.21267059
https://doi.org/10.1101/2021.11.30.21267059
Autor:
Joel H. Vazquez, Stephanie D. Byrum, Hartmut Jaeschke, D. Keith Williams, Samuel G. Mackintosh, Mitchell R. McGill, William E. Lee, Stefanie Kennon-McGill, Jonathan A. Dranoff
Better biomarkers to predict death early in acute liver failure (ALF) are needed. To that end, we obtained early (study day 1) and later (day 3) serum samples from transplant-free survivors (n=28) and non-survivors (n=30) of acetaminophen (APAP)-indu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d993657aa0b3ce5df856233553bcd156
https://doi.org/10.1101/2021.11.30.21266453
https://doi.org/10.1101/2021.11.30.21266453
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, resulting in most patients succumbing rapidly after diagnosis. With limited treatment options available, repurposing of current pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f8e637282145e804eb409e2ba34f64
https://doi.org/10.1101/2021.12.01.470755
https://doi.org/10.1101/2021.12.01.470755
Autor:
Christian Burri, Babatunde Akano, Christian Lengeler, Elizabeth Omoluabi, Jean Okitawutshu, Nina C. Brunner, Gloria Tumukunde, Phyllis Awor, Ocheche Yusuf, Joseph Kimera, Manuel W Hetzel, Jean-Claude Kalenga, Kazeem Ayodeji, Irene Angiro, Charles Okon, James Okuma, Antoinette Tshefu, Tristan T. Lee, Theodoor Visser, Aita Signorell, Proscovia Athieno, Harriet G. Napier, Nadja Cereghetti, Valentina Buj, Giulia Delvento, Mark Lambiris
BackgroundAppropriate clinical management of severe malaria is critical to avert morbidity and death. Recommended treatment consists of an injectable antimalarial followed by a full course of oral artemisinin-based combination therapy (ACT). Children
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5048001edcb16fb53a41dd1b85bec9da
https://doi.org/10.1101/2021.11.26.21266917
https://doi.org/10.1101/2021.11.26.21266917
Autor:
Nicholas E. Vangos, Hyuk-Soo Seo, Takashi Mizutani, Tinghu Zhang, Kenneth C. Anderson, Nathanael S. Gray, Teru Hideshima, Sirano Dhe-Paganon
Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide, and pomalidomide (Pom) bind to cereblon (CRBN) and trigger proteasomal degradation of neo-substrates IKZF1/3 leading to multiple myeloma (MM) cell apoptosis. Pomalidomide (Pom) also binds albe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e9e895d6bc8df555305968acf8003f
https://doi.org/10.1101/2021.11.30.469594
https://doi.org/10.1101/2021.11.30.469594
The present study reports a one-step clean synthesis of carbon dots (CDs) using clove buds and polyvinylpyrrolidone (PVP) as the starting precursor via hydrothermal routes. The adopted technique is facile, reproducible, and cost-effective for the pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59e90dd26d17673bec699b7adb275e60
https://doi.org/10.1101/2021.11.29.470381
https://doi.org/10.1101/2021.11.29.470381
Autor:
Wojciech Glac, Marek Wiergowski, Maciej M. Jankowski, Artur H. Swiergiel, Paulina Kazmierska-Grebowska, Bogna M. Ignatowska-Jankowska
Modulation of dopamine transmission evokes strong behavioral effects that can be achieved by psychoactive drugs such as haloperidol or cocaine. Cocaine non-specifically increases dopamine transmission by blocking dopamine active transporter (DAT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4159dd31c820f9ad18acff746c6e0a9
https://doi.org/10.1101/2021.11.28.470229
https://doi.org/10.1101/2021.11.28.470229
Autor:
Muhammad Asif Gul, Farooq Mohyud Din Chaudhary, Shehryar Kanju, Qasim Umar, Rizwan Hameed, Dure Shahwar
IntroductionHepatitis C has gradually become endemic in Pakistan, with infectivity rates one of the highest in the world. The emergence of direct acting antivirals (DAAs) has become a ray of sunshine in eradicating this menace from this region. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dd7d5e5ac7f500fde0fb35920f558c
https://doi.org/10.1101/2021.11.23.21266653
https://doi.org/10.1101/2021.11.23.21266653
Autor:
Eunus S. Ali, Shreya Budhiraja, Charles David James, Ella Perrault, Anindita Basu, Luke Tomes, Sebastian Pott, Issam Ben-Sahra, Atique Ahmed, Andrew Zolp, Shivani Baisiwala, Peiyu Lin, Isabelle Preddy, Jack Shireman, Cheol Park
Glioblastoma (GBM) remains one of the most resistant and fatal forms of cancer. Previous studies have examined primary and recurrent GBM tumors, but it is difficult to study tumor evolution during therapy where resistance develops. To investigate thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8165007756b8f62ca40b6d1b8f2eb995
https://doi.org/10.1101/2021.11.23.469785
https://doi.org/10.1101/2021.11.23.469785