Zobrazeno 1 - 10
of 556
pro vyhledávání: ''
Autor:
Daniela Araiza-Olivera, James S. Duncan, Carlos Herrera-Montávez, Alison Kurimchak, Jianping Hu, Jian Jin, Sara Montserrat-Sangrà
PROTACs (Proteolysis-Targeting Chimeras) represent a promising new class of drugs that selectively degrade proteins of interest from cells. PROTACs targeting oncogenes are avidly being explored for cancer therapies, with several currently in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66079449e4041a4fdfd269a42a17c4da
https://doi.org/10.1101/2021.12.02.470920
https://doi.org/10.1101/2021.12.02.470920
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease causing irreparable scarring of lung tissue, resulting in most patients succumbing rapidly after diagnosis. With limited treatment options available, repurposing of current pharmaceuti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54f8e637282145e804eb409e2ba34f64
https://doi.org/10.1101/2021.12.01.470755
https://doi.org/10.1101/2021.12.01.470755
Autor:
Eunus S. Ali, Shreya Budhiraja, Charles David James, Ella Perrault, Anindita Basu, Luke Tomes, Sebastian Pott, Issam Ben-Sahra, Atique Ahmed, Andrew Zolp, Shivani Baisiwala, Peiyu Lin, Isabelle Preddy, Jack Shireman, Cheol Park
Glioblastoma (GBM) remains one of the most resistant and fatal forms of cancer. Previous studies have examined primary and recurrent GBM tumors, but it is difficult to study tumor evolution during therapy where resistance develops. To investigate thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8165007756b8f62ca40b6d1b8f2eb995
https://doi.org/10.1101/2021.11.23.469785
https://doi.org/10.1101/2021.11.23.469785
BackgroundPancreatic cancer is a deadly cancer around the world. To reduce side effects and enhance treatment efficacy, study on combination therapy for pancreatic cancer has gained much attention in recent years.MethodsIn this paper, we propose a no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::806434f8b5fa3462d8f24d7027fb90ae
https://doi.org/10.1101/2021.11.19.469215
https://doi.org/10.1101/2021.11.19.469215
Anti-epidermal growth factor receptor (EGFR) therapy–associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis and microbial infection, resulting in a decrease in quality of life and dose int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52bb5cafdc0db5a850185aa652d68186
https://doi.org/10.1101/2021.11.17.468949
https://doi.org/10.1101/2021.11.17.468949
Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein formed by the chromosomal translocation t(11;22). The small molecule TK216 was developed as a first-in-class direct EWSR1-FLI1 inhibitor and is in phase II clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2910bc69b7bfe3cd5647904a712cedfd
https://doi.org/10.1101/2021.11.19.469182
https://doi.org/10.1101/2021.11.19.469182
Autor:
Magdalena Oroń, Marcin Grochowski, Akanksha Jaiswar, Justyna Legierska, Kamil Jastrzębski, Magdalena Nowak-Niezgoda, Małgorzata Kołos, Wojciech Kaźmierczak, Tomasz Olesiński, Małgorzata Lenarcik, Magdalena Cybulska, Michał Mikuła, Alicja Żylicz, Marta Miączyńska, Katherina Zettl, Jacek R. Wiśniewski, Dawid Walerych
Human neoplasias are often addicted to the cellular proteasome machinery. This has led to the development of bortezomib and carfilzomib proteasome inhibitors, approved for the treatment of multiple myeloma. Cancers, however, were found resistant to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8a11310af7ca41fda95f391d3338035
https://doi.org/10.1101/2021.11.16.468807
https://doi.org/10.1101/2021.11.16.468807
Autor:
Jimmy L. Zhao, Michael J. Morris, Katia Manova Todorova, Tianhao Xu, Wouter R. Karthaus, Michael C. Haffner, Dana E. Rathkopf, Natasha Rekhtman, Ignas Masilionis, Afsar Barlas, Kristine M. Wadosky, Howard I. Scher, Dana Pe'er, Joachim Silber, Lawrence D. True, Peter S. Nelson, Joseph M. Chan, Ojasvi Chaudhary, Linas Mazutis, Kayla E. Lawrence, Charles L. Sawyers, Ronan Chaligne, David W. Goodrich, Achim A. Jungbluth, Philip A. Watson, Jungmin Choi, Martin P Roudier, Samir Zaidi, Irina Linkov, Anuradha Gopalan
Lineage plasticity is a well–established mechanism of resistance to targeted therapies in lung and prostate cancer, where tumors transition from adenocarcinoma to small–cell or neuroendocrine carcinoma. Through single–cell analysis of a cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c23edc86fc830f0ed4f2aa44578cb60
https://doi.org/10.1101/2021.11.01.466599
https://doi.org/10.1101/2021.11.01.466599
Autor:
Jiandang Shi, Jinfang Bi, Bohan Chen, Yuyang Qian, Zhongfang Zhao, Tengfei Shi, Anshun He, Frank J. Attenello, Wange Lu, Lei Zhang, Woojin An, Jun Chen, Dianhao Guo, Wenbin Wang
Publikováno v:
Genome Research. 30:155-163
Temozolomide (TMZ) is a frequently used chemotherapy for glioma; however, chemoresistance is a major problem limiting its effectiveness. Thus, knowledge of mechanisms underlying this outcome could improve patient prognosis. Here, we report that delet
Autor:
Christian Hurtz, Lai N. Chan, Scott A. Armstrong, Jianjun Chen, Erica Ballabio, Huimin Geng, Thomas A. Milne, Gauri Deb, Patricia Ernst, Ari Melnick, Haytham Khoury, Chun-Wei Chen, Gang Xiao, Markus Müschen
Publikováno v:
Genes & Development. 33:1265-1279
Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes. Immunohistochemical staining of bone marrow biopsies from most of