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Anti-epidermal growth factor receptor (EGFR) therapy–associated cutaneous toxicity is a syndrome characterized by papulopustular rash, local inflammation, folliculitis and microbial infection, resulting in a decrease in quality of life and dose int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52bb5cafdc0db5a850185aa652d68186
https://doi.org/10.1101/2021.11.17.468949
https://doi.org/10.1101/2021.11.17.468949
Autor:
Alison F. Munro, Richard J. R. Elliott, Rebecca E. Hughes, N. M. Morton, J. R. O'Neill, Ted R. Hupp, K. Fujihara, Carter Rn, Xiaodun Li, Neil O. Carragher, Rebecca C. Fitzgerald, Nicholas J. Clemons, Ashraff Makda
Background and AimsOesophageal adenocarcinoma (OAC) is of increasing global concern due to increasing incidence, a lack of effective treatments, and poor prognosis. Therapeutic target discovery and clinical trials have been hindered by the heterogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::caf4af117e667eabd2b778997ed36369
https://doi.org/10.1101/2021.10.05.463189
https://doi.org/10.1101/2021.10.05.463189
Autor:
Achraf Shamseddine, Suchit H. Patel, Valery Chavez, Zachary R. Moore, Mutayyaba Adnan, Melody Di Bona, Jun Li, Chau T. Dang, Lakshmi V. Ramanathan, Kevin C. Oeffinger, Jennifer E. Liu, Richard M. Steingart, Alessandra Piersigilli, Nicholas D. Socci, Angel T. Chan, Anthony F. Yu, Samuel F. Bakhoum, Adam M. Schmitt
Late cardiac toxicity is a potentially lethal complication of cancer therapy, yet the pathogenic mechanism remains largely unknown, and few treatment options exist. Here we report DNA damaging agents such as radiation and anthracycline chemotherapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2237953230099115119e589a571c4453
https://doi.org/10.1101/2021.09.26.461865
https://doi.org/10.1101/2021.09.26.461865
Autor:
Alejandro Peñín-Franch, José A García-Vidal, Pablo Pelegrín, Fermín Valera-Garrido, Francesc Medina-Mirapeix, Ana I. Gomez, Francisco Minaya-Muñoz, Pilar Escolar-Reina, Carlos Martinez
The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a63e71c7504df56774bd76faf957dce0
https://doi.org/10.1101/2021.09.20.461048
https://doi.org/10.1101/2021.09.20.461048
High incident of lung cancer among never smokers and their disease pathogenesis is an unexplained phenomenon. We have analyzed 1727 lung cancer patient data to understand the impact of smoking on overall survival of lung cancer patients and have obse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73749449f83d3c833b377e462069dfa2
https://doi.org/10.1101/2021.09.08.459287
https://doi.org/10.1101/2021.09.08.459287
Autor:
Kyle P Carter, Yao Y. Chiang, Vishal A. Manickam, Emily Benzie, Nicholas Wayham, David S. Johnson, Rena A. Mizrahi, Jasmeen Saini, Garry L. Coles, Savreet K. Sandhu, Eric A. Stone, Jan Fredrick Simons, Adam S. Adler, Ellen K. Wagner, Ashley Gras, Chelsea Edgar, LaRee Tracy, Brendan Tinsley, Jackson Leong, Kacy Stadtmiller, Ariel R Niedecken, Renee Leong, Yoong Wearn Lim, Bishal K. Gautam, Michael A. Asensio
Anti-CTLA-4 antibodies such as ipilimumab were among the first immune-oncology agents to show significantly improved outcomes for patients. However, existing anti-CTLA-4 therapies fail to induce a response in a majority of patients and can induce sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f6edafd41945bb756870a8746a1366a
https://doi.org/10.1101/2021.07.12.452090
https://doi.org/10.1101/2021.07.12.452090
Autor:
Nicole Valenzuela
Blood endothelial cells actively regulate egress of leukocytes into peripheral tissues in response to inflammatory insult. The resolution of inflammation is critical for healing and return to homeostasis, but the timing and mechanisms involved in ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa312b8c983355e62c4fda90754a2f98
https://doi.org/10.1101/2021.06.18.449043
https://doi.org/10.1101/2021.06.18.449043
Autor:
Jeffrey J. Atkinson, Fatima Zohra Khamissi, Andreas Herrlich, Mai M Abdelmageed, Eirini Kefaloyianni, Akshayakeerthi Arthanarisami
Proximal-tubule-cell EGFR activation mediates tubule cell proliferation and repair early after kidney injury, while sustained EGFR activation causes kidney fibrosis. Inflammation is a key driver of AKI-to-CKD transition and fibrosis, but mechanisms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4525d4fb5daf17e37598188269e129d0
https://doi.org/10.1101/2021.04.29.442002
https://doi.org/10.1101/2021.04.29.442002
Autor:
Barbara Saxty, Joseph Inns, Helen J. Blair, José Luis Marín-Rubio, Olaf Heidenreich, Tiaan Heunis, Jonathan M. Scott, Matthias Trost, James M. Allan, Maria Emilia Dueñas, Rachel E. Heap, A. John Simpson
Inflammatory responses are important in cancer, particularly in the context of monocyte-rich aggressive myeloid neoplasm. We developed a label-free cellular phenotypic drug discovery assay to identify anti-inflammatory drugs in human monocytes derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3adb2e023d75a4eae3fe888fad555ad
https://doi.org/10.1101/2021.03.29.437557
https://doi.org/10.1101/2021.03.29.437557
Autor:
Jonathan Karn, R. Asaad, Aarthi Talla, Natarajan Bhaskaran, Paes da Silva A, Elizabeth Schneider, Fady F. Faddoul, Donald M. McDonald, Pushpa Pandiyan, Alan D. Levine, Michael M. Lederman, N. Greenspan
Residual systemic inflammation and mucosal immune dysfunction persist in people living with HIV (PLWH) despite treatment with combined anti-retroviral therapy (cART), but the underlying immune mechanisms are poorly understood. Here we report an alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf2cdd3672545f7e0a085e17e636fc09
https://doi.org/10.1101/2021.03.13.435273
https://doi.org/10.1101/2021.03.13.435273