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Autor:
Megan Cole, Jesse Boumelha, Miriam Llorian Sopena, Miriam Molina-Arcas, Panos Anastasiou, Sareena Rana, Christopher I. Moore, Febe van Maldegem, Philip East, Julian Downward, Edurne Mugarza, Karishma Valand, Pablo Romero Clavijo, Rachel Ambler
The recent development and approval of KRASG12C inhibitors promises to change profoundly the clinical management of lung cancer patients harbouring KRASG12C mutations. However, early clinical data indicate that acquired drug resistance can frequently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eebd4728b44a095dd96a3a4fd4745a56
https://doi.org/10.1101/2021.10.18.464819
https://doi.org/10.1101/2021.10.18.464819
Autor:
Evelline A. Edson, Katharine G. D. Florêncio, Otília Deusdênia L. Pessoa, Diego Veras Wilke, João Agostinho Machado-Neto, Francisco das Chagas L. Pinto
Some first-line cytotoxic chemotherapics, e.g. doxorubicin, paclitaxel and oxaliplatin, induce activation of the immune system through immunogenic cell death (ICD). Tumor cells undergoing ICD function as a vaccine, releasing damage-associated molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6111c0b0ba6027a9c05d2064e75c0f0e
https://doi.org/10.1101/2021.09.18.460876
https://doi.org/10.1101/2021.09.18.460876
One of the most important areas of medical science is oncology, which is responsible for both the diagnostics and treatment of cancer diseases. Simultaneously one of the main challenges of oncology is the development of modern drugs effective in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e21bc5dd64ba35f42727790d5f259c
https://doi.org/10.1101/2021.08.31.458425
https://doi.org/10.1101/2021.08.31.458425
Autor:
Jean-Simon Diallo, Seung-Hwan Lee, Serena Cortés-Kaplan, Zaid Taha, Scott McComb, Mohammed S. Hasim, Glib Maznyi, Michele Ardolino, Shelby Kaczmarek
Because of their crucial role in tumor immunity, NK cells have quickly become a prime target for immunotherapies, with adoptive transfer of NK cells and the use of NK cell engagers quickly moving to clinical stage. On the other hand, only few studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a8ee67b536654567806d57270cd930
https://doi.org/10.1101/2021.08.20.457155
https://doi.org/10.1101/2021.08.20.457155
Autor:
Gertrud Schäfer, Volkhard Helms, Markus Hoth, Grigorios Christidis, Arne Knörck, Archana K. Yanamandra, Eva C. Schwarz, Caroline Diener, Leticia Soriano-Baguet, Eckart Meese, Leticia Prates Roma, Frank Lammert, Martin Hart, Bin Qu, Wenjuan Yang, Frederic Küppers, Dirk Brenner, Renping Zhao, Andreas Denger
Cytotoxic T lymphocytes (CTLs) are involved in development of diabetes. However, the impact of excessive glucose on CTL-mediated antigen-independent killing remains elusive. Here, we report that TNF-related apoptosis inducing ligand (TRAIL) is substa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8135e253f44cc3ba6f3a7bb59cdeea4b
https://doi.org/10.1101/2021.08.04.455060
https://doi.org/10.1101/2021.08.04.455060
Autor:
Dakota B. Poschel, Zhou G, Dafeng Yang, Priscilla S. Redd, David H. Munn, Alyssa D. Merting, Kebin Liu, Chunwan Lu, John D. Klement
The mechanism underlying tumor cell PD-L1 (tPD-L1) induction of immune suppression through T cell PD-1 is well-known, but the mechanism underlying tPD-L1 induction of immune suppression via an intermediate cell is incompletely understood. We report h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9022eef26a6dd03bc29f2009f2e4b02d
https://doi.org/10.1101/2021.06.18.449028
https://doi.org/10.1101/2021.06.18.449028
Autor:
Christoph Wülfing, Rachel Ambler, David J. Morgan, Stephen Cross, Alamir H, Milodowski E, Gabriel L. Galea, Grace L. Edmunds, Wong Cc
Tumors generate an immune-suppressive environment that prevents effective killing of tumor cells by CD8+ cytotoxic T cells (CTL). It remains largely unclear upon which cell type and at which stage of the anti-tumor response mediators of suppression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80801964a5a741d5e04075cb1b9e8cb9
https://doi.org/10.1101/2021.05.20.444944
https://doi.org/10.1101/2021.05.20.444944
Autor:
Heta Jadhav, Geoffrey I. Shapiro, Renyan Liu, Jennifer L. Guerriero, Constantia Pantelidou, Aditi Kothari
Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy by inducing synthetic lethal effects, as well as cGAS/STING-mediated immune responses in BRCA- and other homologous recombination repair-deficient cancer cells. Here we investigated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15d08b7910eabe87d64ae15ee7c74a0c
https://doi.org/10.1101/2021.01.26.428337
https://doi.org/10.1101/2021.01.26.428337
Cancer treatments often have adverse effects on the quality of life for young women. One of the most relevant negative impacts is the loss of fertility. Cyclophosphamide is one of the most detrimental chemotherapeutic drugs for the ovary. Cyclophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae9885e9ec5b3e2222ce35418234792
https://doi.org/10.1101/2020.12.30.424825
https://doi.org/10.1101/2020.12.30.424825
Autor:
Julie Mussard, Marc Dalod, Gilles Bessou, Marc Ambrosini, Jean-Charles Cancel, Amelien Sanlaville, Jenny Valladeau-Guilemond, Carine Brousse, Christophe Caux, Raphaël Mattiuz, Nathalie Bendriss-Vermare, Karine Crozat
Here we show that efficient breast cancer immunosurveillance relies on cDC1, conventional CD4+ T cells, CD8+ cytotoxic T lymphocytes (CTL) and later NK/NK T cells. For this process, cDC1 were required constitutively, but especially during the T cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2136d1adbec19659f49be704072209a
https://doi.org/10.1101/2020.12.23.424092
https://doi.org/10.1101/2020.12.23.424092