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Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Autor:
Rodrigo de Oliveira Formiga, Flávia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antônia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Márick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clémence Martin, Pierre-Régis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, André Báfica, Véronique Witko-Sarsat, Fernando Spiller
Publikováno v:
bioRxiv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e80654188358ad8cc60996af3801d8
https://europepmc.org/articles/PMC9641843/
https://europepmc.org/articles/PMC9641843/
Autor:
Yuan Hou, Yadi Zhou, Pengyue Zhang, Jielin Xu, Andrew A. Pieper, Yin Huang, Jeffrey L. Cummings, Feixiong Cheng, Chien-Wei Chiang, Lang Li, Lynn M. Bekris, Justin D. Lathia, James B. Leverenz
Publikováno v:
Genome Res
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targe
Autor:
Eric L. Van Nostrand, Jeanine L. Van Nostrand, En-Ching Luo, Kristina Hellberg, Jingting Yu, Yelena Dayn, Reuben J. Shaw, Alina Dayn, Gene W. Yeo, Maxim N. Shokhirev
Publikováno v:
Genes Dev
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic bene
Autor:
Constance Kleijwegt, Armelle Corpet, Pascale Texier, Florent Bressac, Thomas Simonet, C. Cohen, Laurent Schaeffer, Patrick Lomonte
Promyelocytic Leukemia Nuclear Bodies (PML NBs) are nuclear membrane-less organelles physically associated with chromatin underscoring their crucial role in genome function. The H3.3 histone chaperone complex HIRA accumulates in PML NBs upon senescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5c548014c0fdfd56084f791ff466e1
https://doi.org/10.1101/2021.11.30.470516
https://doi.org/10.1101/2021.11.30.470516
BackgroundREGN-COV2, a monoclonal antibody cocktail drug against the SARS-COV-2 virus, has proven to be effective in preventing the development of severe COVID-19 and is increasingly being administered in outpatient and home settings. Adverse events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0a1f1256dc597bef93350b59ee1681f
https://doi.org/10.1101/2021.11.29.21266623
https://doi.org/10.1101/2021.11.29.21266623
Sleep deprivation interferes with long-term memory and cognitive functions by over-activation of phosphodiesterase (PDE) enzymes. PDE4 is a non-redundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus, and is invo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41feac27dc744831bd79f00ab8d9d196
https://doi.org/10.1101/2021.11.28.470251
https://doi.org/10.1101/2021.11.28.470251
Striatal adenosine A1receptor (A1R) activation can inhibit dopamine release. A1Rs on other striatal neurons are activated by an adenosine tone that is limited by equilibrative nucleoside transporter 1 (ENT1) that is enriched on astrocytes and is etha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7bee11b54382993d5e8a8c5dad62fd9
https://doi.org/10.1101/2021.11.27.470186
https://doi.org/10.1101/2021.11.27.470186
SARS-CoV-2 infection hijacks signaling pathways and induces protein-protein interactions between human and viral proteins. Human genetic variation may impact SARS-CoV-2 infection and COVID-19 pathology; however, the genetic variation in these signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0459d9a13c9d71d61941d703434d1b67
https://doi.org/10.1101/2021.11.22.21266712
https://doi.org/10.1101/2021.11.22.21266712
Autor:
Clarissa Ting Li, Adam Li
SARS-CoV-2 enters into the human body mainly through the nasal epithelial cells. Cell entry of SARS-CoV-2 needs to be pre-activated by S1/S2 boundary furin motif cleavage by furin and/or relevant proteases. It is important to locally block SARS-CoV-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6179907a256af03b00ab65f713831d
https://doi.org/10.1101/2021.11.19.469276
https://doi.org/10.1101/2021.11.19.469276