Zobrazeno 1 - 10
of 63
pro vyhledávání: ''
Autor:
Yuan Hou, Yadi Zhou, Pengyue Zhang, Jielin Xu, Andrew A. Pieper, Yin Huang, Jeffrey L. Cummings, Feixiong Cheng, Chien-Wei Chiang, Lang Li, Lynn M. Bekris, Justin D. Lathia, James B. Leverenz
Publikováno v:
Genome Res
Because disease-associated microglia (DAM) and disease-associated astrocytes (DAA) are involved in the pathophysiology of Alzheimer's disease (AD), we systematically identified molecular networks between DAM and DAA to uncover novel therapeutic targe
Autor:
Eric L. Van Nostrand, Jeanine L. Van Nostrand, En-Ching Luo, Kristina Hellberg, Jingting Yu, Yelena Dayn, Reuben J. Shaw, Alina Dayn, Gene W. Yeo, Maxim N. Shokhirev
Publikováno v:
Genes Dev
Despite being the frontline therapy for type 2 diabetes, the mechanisms of action of the biguanide drug metformin are still being discovered. In particular, the detailed molecular interplays between the AMPK and the mTORC1 pathway in the hepatic bene
Autor:
Jason Garcia, Trevor M. Penning, Clementina Mesaros, Yves B Helou, Lillian Perez, Gail S. Prins, Larisa Nonn, Zachary Richards, Kirstin D. Krieger, Peter H. Gann, Rick A. Kittles, Steve Kregel, Candice C. Loitz, Donald J. Vander Griend
Vitamin D deficiency is associated with an increased risk of prostate cancer (PCa) mortality and is hypothesized to contribute to PCa aggressiveness and disparities in African American populations. The prostate epithelium was recently shown to expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::668946bd18c399ffd76481a567f40ad7
https://doi.org/10.1101/2021.11.09.467567
https://doi.org/10.1101/2021.11.09.467567
Autor:
Miao Xu, Wei Zheng, Qi Zhang, Juhyung Lee, Yihong Ye, Hang Xie, Catherine Z. Chen, Peter Radvak, Vivian Cao-Dao, Yue Xu
Spike-mediated entry of SARS-CoV-2 into human airway epithelial cells is an attractive therapeutic target for COVID-19. In addition to protein receptors, the SARS-CoV-2 spike (S) protein also interacts with heparan sulfate, a negatively charged glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2d99c73b5f0a32cd6a26e7209eff200
https://doi.org/10.1101/2021.10.15.464595
https://doi.org/10.1101/2021.10.15.464595
Autor:
Coy D. Heldermon, Mary Elizabeth Law, Mengxiong Wang, Z. M. Dulloo, Brian K. Law, Ronald K. Castellano, Olga A. Guryanova, Elham Yaaghubi, Bradley J. Davis, Amanda F. Ghilardi
Tranexamic Acid (TA) is a clinically used antifibrinolytic that acts as a lysine mimetic to block binding of Plasminogen with Plasminogen activators, preventing conversion of Plasminogen to its proteolytically activated form, Plasmin. Previous studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e9d3507b20c68b9dc3d36ae9b0954b
https://doi.org/10.1101/2021.10.17.464714
https://doi.org/10.1101/2021.10.17.464714
Autor:
Fernanda L. Fonseca, Alexandre Bezerra Conde Figueiredo, Márcia Arissawa, Marcio L. Rodrigues, Fernando de Paiva Conte
Therapeutic strategies against systemic mycoses can involve antifungal resistance and significant toxicity. Thus, novel therapeutic approaches to fight fungal infections are urgent. Monoclonal antibodies (mAbs) are promising tools to fight systemic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfb8a4c6dacf12c3a23e2bd6103e0458
https://doi.org/10.1101/2021.06.11.448165
https://doi.org/10.1101/2021.06.11.448165
Autor:
Florence Guivel-Benhassine, Lisa A. Chakrabarti, Mathieu Hubert, Julian Buchrieser, Nell Saunders, Maaran Michael Rajah, Ludivine Grzelak, Françoise Porrot, Hugo Mouquet, Cyril Planchais, Marija Zivaljic, Alice Bongers, Stacy Gellenoncourt, Rémy Robinot, Jérémy Dufloo, Elodie Bishop, Olivier Schwartz, Delphine Planas
Severe COVID-19 is characterized by lung abnormalities, including the presence of syncytial pneumocytes. Syncytia form when SARS-CoV-2 spike protein expressed on the surface of infected cells interacts with the ACE2 receptor on neighbouring cells. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f71000f3e7c4220dc78e21a40546ded
https://doi.org/10.1101/2021.06.11.448011
https://doi.org/10.1101/2021.06.11.448011
Autor:
Sherman-Baust C, Jessica Li, Maria Isabel Trejo-Zambrano, Felipe Andrade, Eduardo Gómez-Bañuelos, Erika Darrah, Merlin Paz, Iñaki Sanz, Daniel W. Goldman, Chida As, Ferris Dp, Regina Bugrovsky, Yuan Yu, Michelle Petri, Kevin S. Cashman, Yun F. Wang
DNase1L3 deficiency is an inborn error of immunity that causes monogenic systemic lupus erythematosus (SLE) in humans. Here, we identified that one third of patients with sporadic SLE have antibodies to DNase1L3. Like DNase1L3 deficiency, we found th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2d8cda6073a4361df65ae010493693
https://doi.org/10.1101/2021.06.07.21258180
https://doi.org/10.1101/2021.06.07.21258180
Autor:
Kush N. Shah, Marleini Ilanga, Sabona B Simbassa, Bhagath Chirra, Qingquan Chen, Carolyn L. Cannon
Cystic Fibrosis (CF) is a common fatal genetic disease caused by mutations happened to cystic fibrosis transmembrane conductance regulator (CFTR) gene. Lungs of CF patients are often colonized or infected with microorganisms. Drug resistant bacterial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575279ecba98cda77293dd2370d6928f
https://doi.org/10.1101/2021.05.11.443633
https://doi.org/10.1101/2021.05.11.443633
Autor:
Manuel Vicente, Juan Llopis, Kazuya Kikuchi, Michelle M. Collins, Masafumi Minoshima, Antonio Martínez-Sielva, Jussep Salgado-Almario, Beatriz Domingo
The zebrafish embryo has emerged as an excellent model in cardiovascular research. The existing techniques to monitor Ca2+ in the heart based on fluorescent Ca2+ biosensors are limited due to phototoxicity and photobleaching. To overcome these issues
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f410ee42a21619c4bc4524a4d847b6c
https://doi.org/10.1101/2021.05.06.442917
https://doi.org/10.1101/2021.05.06.442917