Zobrazeno 1 - 10
of 113
pro vyhledávání: ''
Autor:
Constance Kleijwegt, Armelle Corpet, Pascale Texier, Florent Bressac, Thomas Simonet, C. Cohen, Laurent Schaeffer, Patrick Lomonte
Promyelocytic Leukemia Nuclear Bodies (PML NBs) are nuclear membrane-less organelles physically associated with chromatin underscoring their crucial role in genome function. The H3.3 histone chaperone complex HIRA accumulates in PML NBs upon senescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be5c548014c0fdfd56084f791ff466e1
https://doi.org/10.1101/2021.11.30.470516
https://doi.org/10.1101/2021.11.30.470516
SARS-CoV-2 infection hijacks signaling pathways and induces protein-protein interactions between human and viral proteins. Human genetic variation may impact SARS-CoV-2 infection and COVID-19 pathology; however, the genetic variation in these signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0459d9a13c9d71d61941d703434d1b67
https://doi.org/10.1101/2021.11.22.21266712
https://doi.org/10.1101/2021.11.22.21266712
Autor:
Ralf-Harto Huebner, Christoph Tabeling, Nils Schallner, Christian Drosten, Terry Jones, Siegbert Rieg, Horst von Bernuth, Uta Merle, Leif E. Sander, Daniel Duerschmied, Barbara Muehlemann, Christine Goffinet, Dietrich August, Victor M. Corman, Norbert Suttorp, JM Doehn, Uwe Koelsch, Olga Staudacher, Achim Lother, Nadine Unterwalder, Charlotte Thibeault, Bengisu Akbil, Daniela Niemeyer, Cédric Hirzel, Alexandra Nieters, Florian Kurth, Christian Nusshag, Tim Meyer, Thomas Doerner, Paula Stubbemann, David Sanchez, Jenny Jansen, Joerg C. Schefold, Valeria Falcone, Thibaud Spinetti, Klaus Warnatz, Christian Meisel, Jan Nikolaus Lieberum, Hartmut Hengel
PurposeSix-19% of critically ill COVID-19 patients display circulating auto-antibodies against type I interferons (IFN-AABs). Here, we establish a clinically applicable strategy for early identification of IFN-AAB-positive patients for potential subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d2f147b460bc5949d7f29fb8ca44cb9
https://doi.org/10.1101/2021.11.12.21266249
https://doi.org/10.1101/2021.11.12.21266249
Autor:
Laura M. Canaday, Alyssa M. McCoy, Jessica D. Resnick, Andrew Pekosz, Dat Nguyen, Hsuan Liu, Harrison Powell
From 2013-2016, the H1N1 component of live, attenuated influenza vaccine (LAIV) performed very poorly in contrast to the inactivated influenza vaccine. We utilized a primary, differentiated human nasal epithelial (hNEC) culture system to assess the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bde2b8f3ba9adb2cc653c96a05264cb5
https://doi.org/10.1101/2021.11.11.468304
https://doi.org/10.1101/2021.11.11.468304
Autor:
Prerna Malaney, Fredrik I. Thege, Vidhi Chandra, Jack Hashem, Jennifer Bailey-Lundberg, Andrew D. Rhim, Hajar Rajaei, Dhwani N. Rupani, Sara L. Manning, S Wörmann, Olivereen Le Roux, Robert W. Cowan, Florencia McAllister
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine(A) to inosine(I). A-to-I editing alters post-transcriptional RNA processing making ADAR1 a critical regulator of gene expression. Consequently, Adar1 has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d197c1a761e9033fce25c9dc651487b
https://doi.org/10.1101/2021.11.03.467127
https://doi.org/10.1101/2021.11.03.467127
Autor:
David Siegel, Timothy J. Henrich, Keith R. Jerome, Rebecca Hoh, Kristen S. Hobbs, Pavitra Roychoudhury, Mary Carrington, Sulggi A. Lee, Michael P. Busch, Deanna L. Kroetz, Tony Pan, Erica A. Gibson, Christopher D. Pilcher, Eunice Wan, Jeffrey Marin, Cassandra Thanh, Hans-Peter Kiem, Meei-Li Huang, Mars Stone, Peter W. Hunt, Steven G. Deeks, Jeffrey M. Milush, Satish K. Pillai, Frederick Hecht, Maureen Martin, Kevin Haworth
ObjectivePrior genomewide association studies have identified variation in MHC Class I alleles andCCR5Δ32as genetic predictors of viral control, especially in “elite” controllers, individuals who remain virally suppressed in the absence of thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::951d70da395584a5fad12c6d68e4ef35
https://doi.org/10.1101/2021.10.31.466670
https://doi.org/10.1101/2021.10.31.466670
Autor:
Tong Li, Kerstin E. Braunstein, Ashley Lau, Seth Blackshaw, Jonathan P. Ling, Ronald L. Schnaar, Anabel Gonzalez-Gil, Juan C. Troncoso, Philip C. Wong, Kevin Tu, Tianyu Cao, Alice Wei, Dong Won Kim
It is unknown whether specific microglia are selectively induced by amyloid-β(Aβ), tau pathologies, or both in combination. To address this, we use single-cell RNA-sequencing to profile mice bearing both Aβ and tau pathologies during Alzheimer's d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62c90c735409d49a77354ada17eb720
https://doi.org/10.1101/2021.10.16.464454
https://doi.org/10.1101/2021.10.16.464454
Autor:
Adam Sateriale, Christopher A. Hunter, Daniel P. Beiting, Boris Striepen, Alexis R. Gibson, Jodi A. Gullicksrud, John G. Doench, Julie B. Engiles, Keenan O’Dea, Jennifer E. Dumaine
Cryptosporidiumis a leading cause of severe diarrhea and diarrheal-related death in children worldwide. As an obligate intracellular parasite,Cryptosporidiumrelies on intestinal epithelial cells to provide a niche for its growth and survival, but lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c62b93799039a6ab8ea5c193226022e1
https://doi.org/10.1101/2021.10.06.463303
https://doi.org/10.1101/2021.10.06.463303
Autor:
Jonas N. Conde, Grace Himmler, William R. Schutt, Hwan Keun Kim, Nicholas Saladino, Santiago Sanchez-Vicente, Elena E. Gorbunova, Jorge L. Benach, Erich R. Mackow, Megan C. Mladinich
Publikováno v:
J Virol
Powassan viruses (POWVs) are neurovirulent tick-borne flaviviruses emerging in the Northeastern U.S., with a 2% prevalence in Long Island (LI) deer ticks (Ixodes scapularis). POWVs are transmitted in as little as 15 minutes of a tick bite, and enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3292be9ab9872c57d3e713de5b458b66
https://doi.org/10.1101/2021.09.30.462684
https://doi.org/10.1101/2021.09.30.462684
Autor:
Samuel J. Vidal, Jacob D. Estes, Dan H. Barouch, Michael Nekorchuk, Sarah Ducat, Cesar Piedra-Mora, Carly E. Starke, Colarusse A, Stephen Bondoc, Chi Ngai Chan, Kathleen Busman-Sahay, Aid M, Amanda J. Martinot
Syrian golden hamsters exhibit features of severe disease after SARS-CoV-2 challenge and are therefore useful models of COVID-19 pathogenesis and prevention with vaccines. Recent studies have shown that SARS-CoV-2 infection stimulates type I interfer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36e960b326e6967817aefb37941e1739
https://doi.org/10.1101/2021.09.30.462514
https://doi.org/10.1101/2021.09.30.462514