Zobrazeno 1 - 10
of 2 302
pro vyhledávání: ''
Publikováno v:
RNA. 28:239-249
SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed −1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coa
Autor:
Charlotte Flory, Kitt Wing Ki Chan, Jade K. Forwood, Julien Lescar, Sai Wang, Min Jie Alvin Tan, Dahai Luo, Subhash G. Vasudevan
Publikováno v:
RNA. 28:177-193
The commitment to replicate the RNA genome of flaviviruses without a primer involves RNA-protein interactions that have been shown to include the recognition of the stem-loop A (SLA) in the 5' untranslated region (UTR) by the nonstructural protein NS
Autor:
Natalia B Nedelsky, J. Paul Taylor
Publikováno v:
RNA
The genetics of human disease serves as a robust and unbiased source of insight into human biology, both revealing fundamental cellular processes and exposing the vulnerabilities associated with their dysfunction. Over the last decade, the genetics o
Autor:
Peiyong Jiang, Meng Ni, Y.M. Dennis Lo, Danny K L Wong, Diana S.C. Han, K.C. Allen Chan, Rossa W.K. Chiu, Rebecca W.Y. Chan, Kathy O. Lui, Linda T. Hiraki, Stefano Volpi
Publikováno v:
Genome Res
The effects of DNASE1L3 or DNASE1 deficiency on cell-free DNA (cfDNA) methylation were explored in plasma of mice deficient in these nucleases and in DNASE1L3-deficient humans. Compared to wild-type cfDNA, cfDNA in DNASE1L3-deficient mice was signifi
Publikováno v:
RNA
The conventional view regarding regulation of gene expression is based on transcription control. However, a growing number of recent studies has revealed the important additional impact of translational regulation. Eukaryotic translational machinery
Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
Publikováno v:
RNA. 27:1374-1389
Toxin–antitoxin (TA) systems are genetic modules composed of a toxin interfering with cellular processes and its cognate antitoxin, which counteracts the activity of the toxin. TA modules are widespread in bacterial and archaeal genomes. It has bee
Publikováno v:
RNA
Many antibiotics that bind to the ribosome inhibit translation by blocking the movement of tRNAs and mRNA or interfering with ribosome dynamics, which impairs the formation of essential translocation intermediates. Here we show how translocation inhi
Autor:
Rui Fu, Neelanjan Mukherjee, William E. Rainey, Amber Baldwin, Kathryn Walters, Kimberly Wellman, Juilee Rege, Kent Riemondy, Antje Hirsekorn
Publikováno v:
RNA
Angiotensin II (AngII) binds to the type I angiotensin receptor in the adrenal cortex to initiate a cascade of events leading to the production of aldosterone, a master regulator of blood pressure. Despite extensive characterization of the transcript
Autor:
Valery F. Thompson, Jacob C. Schwartz, Michelle A Lay, Nasiha S. Ahmed, Lucas M. Harrell, Daniel R. Wieland
Publikováno v:
RNA
Ewing sarcoma is driven by fusion proteins containing a low complexity (LC) domain that is intrinsically disordered and a powerful transcriptional regulator. The most common fusion protein found in Ewing sarcoma, EWS-FLI1, takes its LC domain from th