Zobrazeno 1 - 10
of 61
pro vyhledávání: ''
Neuraminidase inhibitors rewire neutrophil function in vivo in murine sepsis and ex vivo in COVID-19
Autor:
Rodrigo de Oliveira Formiga, Flávia C. Amaral, Camila F. Souza, Daniel A. G. B. Mendes, Carlos W. S. Wanderley, Cristina B. Lorenzini, Adara A. Santos, Juliana Antônia, Lucas F. Faria, Caio C. Natale, Nicholas M. Paula, Priscila C. S. Silva, Fernanda R. Fonseca, Luan Aires, Nicoli Heck, Márick R. Starick, Celso M. Queiroz-Junior, Felipe R. S. Santos, Filipe R. O. de Souza, Vivian V. Costa, Shana P. C. Barroso, Alexandre Morrot, Johan Van Weyenbergh, Regina Sordi, Frederico Alisson-Silva, Fernando Q. Cunha, Edroaldo L. Rocha, Sylvie Chollet-Martin, Maria Margarita Hurtado-Nedelec, Clémence Martin, Pierre-Régis Burgel, Daniel S. Mansur, Rosemeri Maurici, Matthew S. Macauley, André Báfica, Véronique Witko-Sarsat, Fernando Spiller
Publikováno v:
bioRxiv
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e80654188358ad8cc60996af3801d8
https://europepmc.org/articles/PMC9641843/
https://europepmc.org/articles/PMC9641843/
Autor:
Keiko Morotomi-Yano, Ken Ichi Yano
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
DNA topoisomerase II (TOP2) is a nuclear protein that resolves DNA topological problems and plays critical roles in multiple nuclear processes. Human cells have two TOP2 proteins, TOP2A and TOP2B, that are localized in both the nucleoplasm and nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5818751d318cc90568dc1cfcdf469122
https://doi.org/10.1101/2021.09.29.462339
https://doi.org/10.1101/2021.09.29.462339
Autor:
Beth A. Bouchard, Christos Colovos, Michael Lawson, Zachary Osborn, Adrian Sackheim, Kara J. Mould, William J. Janssen, Mitchell J. Cohen, Devdoot Majumdar, Kalev Freeman
Publikováno v:
Vascular Pharmacology
Coagulopathy in severe COVID-19 is common but poorly understood. The purpose of this study was to determine how SARS-CoV-2 infection impacts histone levels, fibrin structure, and endogenous thrombin potential in the presence and absence of endothelia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bfcd4989006ab33f91be8e8cf46e870
https://doi.org/10.1101/2021.07.03.450992
https://doi.org/10.1101/2021.07.03.450992
Publikováno v:
Environmental Science & Technology Letters
Airborne virus transmission during the COVID-19 pandemic increased the demand for indoor air cleaners. While some commercial electronic air cleaners could be effective in reducing primary pollutants and inactivating bioaerosol, studies on the formati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a317d1f627fcbc12b195bd5e14879ba6
https://doi.org/10.1101/2021.06.01.21258186
https://doi.org/10.1101/2021.06.01.21258186
Autor:
Netty Santoso, Jian Zhu, Ayan Biswas, Tai-Wei Li, Adam D. Kenney, Jacob S. Yount, Dawei Zhou, Guillaume Fiches, Helu Liu, Jianwen Que
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
SummarySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection leads to NF-κB activation and induction of pro-inflammatory cytokines, though the underlying mechanism for this activation is not fully understood. Our results reveal that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0becffcf5fc2310032c05f266c7c5ea1
https://doi.org/10.1101/2021.05.26.445787
https://doi.org/10.1101/2021.05.26.445787
Autor:
Andrew Owen, Henry Pertinez, Giancarlo A. Biagini, Joanne Sharp, Usman Arshad, Lee Tatham, Anthony Valentijn, Rajith K. R. Rajoli, Helen Box, Megan Neary, Paul Curley, Steve P. Rannard
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Currently nitazoxanide is being assessed as a candidate therapeutic for SARS-CoV-2. Unlike many other candidates being investigated, tizoxanide (the active metabolite of nitazoxanide) plasma concentrations achieve antiviral levels after administratio
Autor:
Kaleb B. Tsegay, Christiana M. Adeyemi, Edward P. Gniffke, D. Noah Sather, John K. Walker, Stephen E. P. Smith
Publikováno v:
bioRxiv
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84380bd8a316ef3bfba219152986def5
https://doi.org/10.1101/2021.04.08.439071
https://doi.org/10.1101/2021.04.08.439071
Autor:
Racheal N. McVicar, Karsten Zengler, Adam P. Cribbs, Alex E. Clark, Andrea Denardo, Elizabeth M. Kwong, Sydney A. Majowicz, Xin Yin, Ann Piermatteo, Daniel R. Sandoval, Joanna K.C. Coker, Chelsea Nora, Ben A. Croker, Udo Oppermann, Kaare V. Grunddal, Blake M. Hauser, Catrine Johansson, Mark A Tye, Gregory J. Golden, Timothy M. Caradonna, Jeffrey D. Esko, Martin Philpott, Anoop Narayanan, Philip L.S.M. Gordts, N Connor Payne, Joyce Jose, Eric R. Griffis, Sotirios Tsimikas, Ryan J. Weiss, Micheal Downes, Jason A. Magida, Thomas Mandel Clausen, Aaron G. Schmidt, Yuan Pu, Cameron J. Nowell, Carlo Ballatore, Thibault Alle, Charlotte B. Spliid, Jared Feldman, Ronald M. Evans, Sumit K. Chanda, Sandra L. Leibel, Aaron F. Garretson, James E. Dunford, Ralph Mazitschek, Aaron F. Carlin
Publikováno v:
bioRxiv
Summary ParagraphWe identify the prolyl-tRNA synthetase (PRS) inhibitor halofuginone1, a compound in clinical trials for anti-fibrotic and anti-inflammatory applications2, as a potent inhibitor of SARS-CoV-2 infection and replication. The interaction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3387ce706f91aec434a2d597280b9361
https://doi.org/10.1101/2021.03.22.436522
https://doi.org/10.1101/2021.03.22.436522
Autor:
J. Brent Friesen, Scott A. Oakes, Shao-Nong Chen, Haley Gula, Vlad Nicolaescu, Long Chi Nguyen, Guido F. Pauli, David O. Meltzer, J. Michael Millis, Dongbo Yang, Nir Drayman, Christopher Dann, Diane Silva, Adil Mohamed, Krysten A. Jones, Bryan C. Dickinson, Thomas J. Best, Marsha Rich Rosner, Glenn Randall, Savaş Tay
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The rapid spread of COVID-19 underscores the need for new treatments. Here we report that cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b10d2f0dc4530f1efcce517ea54f5a53
https://doi.org/10.1101/2021.03.10.432967
https://doi.org/10.1101/2021.03.10.432967
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 22, Pp 14148-14153 (2021)
ACS Omega, Vol 6, Iss 22, Pp 14148-14153 (2021)
We recently developed the SiMPl plasmid toolbox, which is constituted by pairs of plasmids, generically indicated as pSiMPlx_N and pSiMPlx_C, which can be stably maintained in Escherichia coli with a single antibiotic x. The method exploits the split
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17c32740aa1717c28e59abcc933fef49
https://doi.org/10.1101/2021.02.04.429595
https://doi.org/10.1101/2021.02.04.429595