Zobrazeno 1 - 10
of 106
pro vyhledávání: ''
Autor:
Sylvie Behillil, Maryline Bourgine, Maxime Chazal, Sylvie van der Werf, Marco Vignuzzi, Nolwenn Jouvenet, Christope Malabat, Piergiuseppe Quarato, Germano Cecere, Thomas Vallet, Meetali Singh, Loan Bourdon, Nathalie Sauvonnet, Giulia Nigro, Flora Donati
SARS-CoV-2 infection results in impaired interferon response in severe COVID-19 patients. However, how SARS-CoV-2 interferes with host immune response is incompletely understood. Here, we sequenced small RNAs from SARS-CoV-2-infected human cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8198dcc721689e506d7ae8f9afb3f020
https://doi.org/10.1101/2021.09.09.459577
https://doi.org/10.1101/2021.09.09.459577
Autor:
Serge Mazères, Stephen Adonai Leon-Icaza, Mohamed Lamkanfi, Karin Santoni, Christine T.N. Pham, Jean-Philippe Girard, Etienne Meunier, Emilie Doz-Deblauwe, Audrey Hessel, Odile Burlet-Schiltz, Christophe Paget, David Péricat, Aylward F, Yoann Rombouts, Anne Gonzalez-de-Peredo, Salimata Bagayoko, Nathalie Winter, Renaud Poincloux, Pierre-Jean Bordignon, Céline Cougoule, Rémi Planès, Emma Lefrançais, Elisabeth Bellard, Miriam Pinilla, Abdderrahim R
Multiple neutrophil death programs contribute to host defense against infections. Although expressing all necessary components, neutrophils specifically fail to undergo pyroptosis, a lytic form of cell death triggered by the activation of the pro-inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f99cee53f9a193b6ca7c112e8123483
https://doi.org/10.1101/2021.06.28.450116
https://doi.org/10.1101/2021.06.28.450116
Autor:
Hans-Reimer Rodewald, Thomas Winkler, Rodriguez Correa E, Xi Wang, Robyn Laura Kosinsky, Dietlein N, Erbil B, Daniel B. Lipka, Yvonne Begus-Nahrmann, Steven A. Johnsen
Interferons protect from virus infections by inducing hundreds of interferon-stimulated genes (ISG) which orchestrate anti-viral adaptive and innate immunity. Upon viral infection or type I interferon (IFN) stimulation of cell lines, a histone modifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b97fe763a0803033dffd28a9059b08ae
https://doi.org/10.1101/2021.04.09.439190
https://doi.org/10.1101/2021.04.09.439190
Autor:
Jan Bouchal, Wytske M. van Weerden, Vladimír Študent, Zoran Culig, Martin Morong, Stanislav Drápela, Daniela Kurfürstová, Barbora Kvokackova, Radek Fedr, Martin Puhr, Karel Souček
BackgroundDocetaxel resistance represents a leading obstacle in the therapy of prostate cancer (PCa), resulting in lethal disease. Intratumoral heterogeneity, which is frequently driven by epithelial-mesenchymal plasticity significantly contributes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06e0a02611c88c6759b3e22b9c27403
https://doi.org/10.1101/2021.01.28.428577
https://doi.org/10.1101/2021.01.28.428577
Autor:
Antonio Dominguez-Meijide, Rosana Chehín, Markus Zweckstetter, Florencia González-Lizárraga, Sequeira S, Laura Smeldy Jurado Medina, Tiago F. Outeiro, Del Bel E, Sergio B. Socías, Parrales, Maria-Sol Cima-Omori, R. Raisman-Vozari, Patrick P. Michel, Diego Ploper
Tauopathies are neurodegenerative disorders with increasing incidence and still without cure. The extensive time required for development and approval of novel therapeutics highlights the need for testing and repurposing known safe molecules. Since d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b503f7ccc8772734c66118f190cca6e
https://doi.org/10.1101/2020.11.18.388561
https://doi.org/10.1101/2020.11.18.388561
Autor:
Ryan D. Huff, Spencer Revill, Vincent Hou, Cathy Cao, Yechan Kim, Nicholas Tiessen, Jennifer A. Aguiar, Andrew C. Doxey, Matthew S. Miller, Jeremy A. Hirota, Kjetil Ask, Mark D. Inman
IntroductionOver 300 million people in the world live with asthma, resulting in 500,000 annual global deaths with future increases expected. It is estimated that around 50-80% of asthma exacerbations are due to viral infections. Currently, a combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b974130270e953bfc3cec28438a1bcd
https://doi.org/10.1101/2020.11.09.375089
https://doi.org/10.1101/2020.11.09.375089
Current malaria control efforts rely significantly on artemisinin combinational therapies which have played massive roles in alleviating the global burden of the disease. Emergence of resistance to artemisinins is therefore, not just alarming but req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a83a4415abd2c16b6610c1e39ad1467
https://doi.org/10.1101/2020.08.13.249425
https://doi.org/10.1101/2020.08.13.249425
Autor:
Fong Cheng Pan, Fuyu Duan, Xiaohua Duan, Sean Houghton, Liuliu Yang, Tuo Zhang, Lewis C. Cantley, Jenny Xiang, Duc T. Nguyen, David D. Ho, Skyler Uhl, Hui Wang, Xuming Tang, Zeping Zhao, Dong Xu, Yuling Han, David Redmond, Tomer M. Yaron, Xing Wang, Benjamin R. tenOever, Yaoxing Huang, Robert E. Schwartz, Jared L. Johnson, Pengfei Wang, Huanhuan Joyce Chen, Shuibing Chen, Yaron Bram, Benjamin E. Nilsson-Payant, Todd Evans
Publikováno v:
bioRxiv
Summary ParagraphThe SARS-CoV-2 virus has caused already over 3.5 million COVID-19 cases and 250,000 deaths globally. There is an urgent need to create novel models to study SARS-CoV-2 using human disease-relevant cells to understand key features of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732c14cb2898a099f2b71605c9f5110d
https://doi.org/10.1101/2020.05.05.079095
https://doi.org/10.1101/2020.05.05.079095
Publikováno v:
'Nature Communications ', vol: 12, pages: 2199-1-2199-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Norepinephrine is a biogenic amine neurotransmitter that has widespread effects on alertness, arousal and pain sensation. Consequently, blockers of norepinephrine uptake have served as vital tools to treat depression and chronic pain. Here, we employ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a3b14f38e7022e3ec6d644b991edea4
https://doi.org/10.1101/2020.04.30.070219
https://doi.org/10.1101/2020.04.30.070219
Autor:
Erica S. Spatz, Deneen Vojta, Rohan Khera, Yuan Lu, Sheng Ren, Saad B. Omer, Brandon Truax, Callahan Clark, Harlan M. Krumholz, Yinglong Guo, Zhenqiu Lin, Karthik Murugiah
Publikováno v:
medRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Background: Whether angiotensin-converting enzyme (ACE) Inhibitors and angiotensin receptor blockers (ARBs) mitigate or exacerbate SARS-CoV-2 infection remains uncertain. In a national study, we evaluated the association of ACE inhibitors and ARB wit