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Publikováno v:
Antimicrobial Agents and Chemotherapy
Since its conditional approval in 2012, bedaquiline (BDQ) has been a valuable tool for treatment of drug-resistant tuberculosis. More recently, a novel short-course regimen combining BDQ with pretomanid and linezolid won approval to treat highly drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45fb0cc4b1d7db9d9b7e4040e920eab
https://doi.org/10.1101/2020.11.17.387977
https://doi.org/10.1101/2020.11.17.387977
Autor:
Gláucio Mosimann Júnior, Simone Monzani Vivaldini, Gerson Fernando Mendes Pereira, Rachel Abraão Ribeiro, Wildo Navegantes de Araújo, Karen Cristine Tonini
Publikováno v:
Brazilian Journal of Infectious Diseases, Volume: 25, Issue: 2, Article number: 101573, Published: 31 MAY 2021
Brazilian Journal of Infectious Diseases v.25 n.2 2021
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Vol 25, Iss 2, Pp 101573-(2021)
Brazilian Journal of Infectious Diseases v.25 n.2 2021
Brazilian Journal of Infectious Diseases
Brazilian Society of Infectious Diseases (BSID)
instacron:BSID
Brazilian Journal of Infectious Diseases, Vol 25, Iss 2, Pp 101573-(2021)
Treating hepatitis C virus (HCV) infections reduces overall mortality and the risk of multiple extrahepatic complications. Direct-acting antivirals (DAAs) are molecules that target specific non-structural proteins of the virus, resulting in the disru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b12143f8622f499351a0167044dc3ac
https://doi.org/10.1101/2020.10.06.20207274
https://doi.org/10.1101/2020.10.06.20207274
Autor:
Mart Ustav, Aleksandr Ianevski, Evgeny Kulesskiy, Gaily Kivi, Kirsti Løseth, Andres Männik, Mona H. Fenstad, Marc P. Windisch, Kristiina Kurg, Eva Zusinaite, Tanel Tenson, Jaewon Yang, Per Arne Aas, Denis E. Kainov, Valentyn Oksenych, Svetlana Biza, Astra Vitkauskiene, Magnar Bjørås, Svein Arne Nordbø, Eunji Jo, Hilde Lysvand, Nastassia Shtaida, Anu Planken, Rouan Yao, Eva-Maria Tombak
Combination therapies have become a standard for the treatment for HIV and HCV infections. They are advantageous over monotherapies due to better efficacy and reduced toxicity, as well as the ability to prevent the development of resistant viral stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae5a0f8ce76fb598e9abf2bb4dfb5cf
https://doi.org/10.1101/2020.09.17.299933
https://doi.org/10.1101/2020.09.17.299933
Autor:
Thomas R. Ioerger, Jin Lee, Keshav Shah, Jean Philippe Lanoix, Dalin Rifat, Ghader Bashiri, Eric L. Nuermberger, James C. Sacchettini, Si-Yang Li
Publikováno v:
Antimicrob Agents Chemother
The nitroimidazole pro-drugs delamanid and pretomanid comprise one of only two new antimicrobial classes approved to treat tuberculosis (TB) in 50 years. Prior in vitro studies suggest a relatively low barrier to nitroimidazole resistance in Mycobact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a820ae68d98fdaf0b069e62cf70104a
https://doi.org/10.1101/2020.09.10.292508
https://doi.org/10.1101/2020.09.10.292508
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0239354 (2020)
PLoS ONE, Vol 15, Iss 11, p e0239354 (2020)
We previously identified a diazaborine series with potential for development as a new tuberculosis drug. This series has activity in vitro and in vivo and targets cell wall biosynthesis via inhibition of InhA. The overall aim of this study was to det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b023b00f8faad5143ef993aa8efab4d0
https://doi.org/10.1101/2020.08.19.257782
https://doi.org/10.1101/2020.08.19.257782
Autor:
Shivani Krishna Kapuganti, Rajanish Giri, Victor Vitoldovich Poboinev, Tatyana Aleksandrovna Khrustaleva, Vladislav Victorovich Khrustalev, Aleksander Nicolaevich Stojarov
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
Frontiers in Microbiology
Frontiers in Microbiology
Within 4 months of the ongoing COVID-19 pandemic caused by SARS-CoV-2, more than 250 nucleotide mutations have been detected in ORF1ab of the virus isolated from infected persons from different parts of the globe. These observations open up an obviou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12cacfbe4de479cc7b0fa5d4d9aebe4
https://doi.org/10.1101/2020.05.05.078238
https://doi.org/10.1101/2020.05.05.078238
Autor:
Laura J. Stevens, Mark R. Denison, Alexandra Schäfer, James D. Chappell, Bin Ma, David R. Martinez, Maria L. Agostini, Jason K. Perry, Rachel L. Graham, John P. Bilello, Jared Pitts, Kendra Gully, Danielle Porter, Ariane J. Brown, Eisuke Murakami, Venice Du Pont, Timothy P. Sheahan, Sarah R. Leist, Kenneth H. Dinnon, Darius Babusis, Boyd Yount, Lisa E. Gralinksi, Tia M. Hughes, Ralph S. Baric, Joy Y. Feng, Xiaotao Lu, Andrea J. Pruijssers, Tomas Cihlar, Amelia S. George
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 as the causative agent of the novel pandemic viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for safe, broad-spectrum antiviral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55d39047893773d908934086bdfb9634
EsxA has long been recognized as an important virulence factor of Mycobacterium tuberculosis (Mtb) that plays an essential role in Mtb cytosolic translocation presumably by penetrating phagosomal membranes with its acidic pH-dependent membrane permea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b255e3f239d63e03770c642f70658b0
Autor:
Steenwyk, Jacob L., Mead, Matthew E., Knowles, Sonja L., Raja, Huzefa A., Roberts, Christopher D., Bader, Oliver, Houbraken, Jos, Goldman, Gustavo H., Oberlies, Nicholas H., Rokas, Antonis
Aspergillus fumigatus is a major human pathogen that causes hundreds of thousands of infections yearly with high mortality rates. In contrast, Aspergillus fischeri and the recently described Aspergillus oerlinghausenensis, the two species most closel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e2bbbcce73b1f22503219634c8956b
https://doi.org/10.1101/2020.04.09.033902
https://doi.org/10.1101/2020.04.09.033902
Autor:
Bruno Coutard, Franck Touret, Antoine Nougairède, Etienne Decroly, Xavier de Lamballerie, Magali Gilles, Karine Barral
SummaryA novel coronavirus, named SARS-CoV-2, emerged in 2019 from Hubei region in China and rapidly spread worldwide. As no approved therapeutics exists to treat Covid-19, the disease associated to SARS-Cov-2, there is an urgent need to propose mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e7ec1367e5ff23787a390ebdd21e3a
https://doi.org/10.1101/2020.04.03.023846
https://doi.org/10.1101/2020.04.03.023846