Zobrazeno 1 - 10
of 23 737
pro vyhledávání: ''
Autor:
Cody Ashby, Brian A Walker, Marco Trevisan-Herraz, Sharmilan Thanendrarajan, Kent Fung, Agata Cieslak, Shmuel Yaccoby, Maurizio Zangari, Aneta Mikulasova, Daniel Rico, Vahid Asnafi, Lisa J. Russell, Nefeli Karataraki, Anne E. Corcoran, Daniel Kent, Sophie Hambleton, Carolina Schinke, Gareth J. Morgan, Salvatore Spicuglia, Frits van Rhee, Chris A. Brackley
Publikováno v:
Mikulasova, A, Kent, D, Trevisan-Herraz, M, Karataraki, N, Fung, K T M, Ashby, C, Cieslak, A, Yaccoby, S, van Rhee, F, Zangari, M, Thanendrarajan, S, Schinke, C, Morgan, G J, Asnafi, V, Spicuglia, S, Brackley, C A, Corcoran, A E, Hambleton, S, Walker, B A, Rico, D & Russell, L J 2021, ' Epigenomic translocation of H3K4me3 broad domains over oncogenes following hijacking of super-enhancers ', Genome Research, vol. 2022, 32, pp. 1343-1354 . https://doi.org/10.1101/gr.276042.121
Chromosomal translocations are important drivers of haematological malignancies whereby proto-oncogenes are activated by juxtaposition with enhancers, often called enhancer hijacking. We analysed the epigenomic consequences of rearrangements between
Publikováno v:
RNA
Exciting recent work has highlighted that numerous cellular compartments lack encapsulating lipid bilayers (often called “membraneless organelles”), and that their structure and function are central to the regulation of key biological processes,
Autor:
Maithe Arruda-Carvalho, Agarsh Satheesh, Arely Cruz-Sanchez, Rojina Samifanni, Unza Mumtaz, Mudi Zhao
Publikováno v:
Learning & Memory. 28:414-421
The ability to generate memories that persist throughout a lifetime (that is, memory persistence) emerges in early development across species. Although it has been shown that persistent fear memories emerge between late infancy and adolescence in mic
Publikováno v:
Genes & Development. 35:1368-1382
The alternative PCNA loader containing CTF18-DCC1-CTF8 facilitates sister chromatid cohesion (SCC) by poorly defined mechanisms. Here we found that in DT40 cells, CTF18 acts complementarily with the Warsaw breakage syndrome DDX11 helicase in mediatin
Publikováno v:
Genes & Development. 35:1271-1289
PARP inhibitor (PARPi) is widely used to treat BRCA1/2-deficient tumors, but why PARPi is more effective than other DNA-damaging drugs is unclear. Here, we show that PARPi generates DNA double-strand breaks (DSBs) predominantly in a trans cell cycle
Evolution and genomic signatures of spontaneous somatic mutation in Drosophila intestinal stem cells
Publikováno v:
Genome Res
Spontaneous mutations can alter tissue dynamics and lead to cancer initiation. While large-scale sequencing projects have illustrated processes that influence somatic mutation and subsequent tumour evolution, the mutational dynamics operating in the
Autor:
Daniel Butler, Kerry George, Jonathan Foox, Jared J. Luxton, Miles J. McKenna, Christopher E. Mason, Daniela Bezdan, Lynn Taylor, Kirill Grigorev, Cem Meydan, Susan M. Bailey, Jake Reed
Publikováno v:
Genome Res
Telomeres are regions of repetitive nucleotide sequences capping the ends of eukaryotic chromosomes that protect against deterioration, and whose lengths can be correlated with age and adverse health risk factors. Yet, given their length and repetiti
Autor:
Peter B. Becker, Aline Campos Sparr, Andreas W. Thomae, Tobias Straub, Janosch Hennig, Raffaella Villa, Ignasi Forné, Pravin Kumar Ankush Jagtap
Publikováno v:
Genes & Development. 35:1055-1070
The dosage compensation complex (DCC) ofDrosophilaidentifies its X-chromosomal binding sites with exquisite selectivity. The principles that assure this vital targeting are known from theD. melanogastermodel: DCC-intrinsic specificity of DNA binding,
Autor:
Trudy F. C. Mackay, Sneha S. Mokashi, Brandon M. Baker, Jeffrey S. Hatfield, Rachel C. Hannah, Vijay Shankar, Robert R. H. Anholt
Publikováno v:
Genome Research. 31:1927-1937
Whereas the neurological effects of cocaine have been well documented, effects of acute cocaine consumption on genome-wide gene expression across the brain remain largely unexplored. This question cannot be readily addressed in humans but can be appr
Autor:
Rowan P. Herridge, Jonathan Cahn, Robert A. Martienssen, Daniel Grimanelli, Jean-Sébastien Parent
Publikováno v:
Genes Dev
Epigenetic reprogramming occurs during gametogenesis as well as during embryogenesis to reset the genome for early development. In flowering plants, many heterochromatic marks are maintained in sperm, but asymmetric DNA methylation is mostly lost. As