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Autor:
Qi Zhan, Mengjie Chen, Jinlin Miao, Yang I. Li, Zepeng Mu, Zhaohui Zheng, Ping Zhu, Lili Wang
Publikováno v:
Genome Res
Single-cell RNA sequencing (scRNA-seq) technology is poised to replace bulk cell RNA sequencing for many biological and medical applications as it allows users to measure gene expression levels in a cell type–specific manner. However, data produced
Publikováno v:
Genome Research. 31:110-120
Quantifying and comparing the amount of adaptive evolution among different species is key to understanding how evolution works. Previous studies have shown differences in adaptive evolution across species; however, their specific causes remain elusiv
Autor:
Catherine C. Kaczorowski, Sarah M. Neuner, Sarah E. Heuer, Robert W. Williams, Niran Hadad, Chris Gaiteri, Vivek M. Philip, Kristen M.S. O'Connell
Publikováno v:
Learn Mem
Individual differences in cognitive decline during normal aging and Alzheimer's disease (AD) are common, but the molecular mechanisms underlying these distinct outcomes are not fully understood. We utilized a combination of genetic, molecular, and be
Autor:
Henry W. Schmidt, Kelly M. Balmant, William B. Barbazuk, Jerald D. Noble, Matias Kirst, Daniel Conde, Gustavo de los Campos, Ana I. Vazquez, Marcio F. R. Resende, Christopher Dervinis, Filipe Couto Alves
Publikováno v:
Genome Res
Despite the growing resources and tools for high-throughput characterization and analysis of genomic information, the discovery of the genetic elements that regulate complex traits remains a challenge. Systems genetics is an emerging field that aims
Autor:
Jianming Yu, Qi Mu, Akio Onogi, Xianran Li, Tingting Guo, Adam Vanous, Hiroyoshi Iwata, Jinyu Wang
Publikováno v:
Genome Res
The phenotypic variation of living organisms is shaped by genetics, environment, and their interaction. Understanding phenotypic plasticity under natural conditions is hindered by the apparently complex environment and the interacting genes and pathw
Publikováno v:
Learning & Memory. 27:52-66
In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1
Publikováno v:
Learning & Memory. 27:1-5
Conditioned fear memories that are context-specific shortly after conditioning generalize over time. We exposed rats to a context reminder 30 d after conditioning, which served to reinstate context-specificity, and investigated how this reminder alte
Autor:
Philipp Korber, Mark Heron, Nils Krietenstein, Helmut Blum, Stefan Krebs, Jessica L Ellins, Andrea Schmid, Elisa Oberbeckmann, Michael Roland Wolff, Ulrich Gerland
Publikováno v:
Genome Research. 29:1996-2009
Mapping of nucleosomes, the basic DNA packaging unit in eukaryotes, is fundamental for understanding genome regulation because nucleosomes modulate DNA access by their positioning along the genome. A cell-population nucleosome map requires two observ
Autor:
Robert R. H. Anholt, Shanshan Zhou, Trudy F. C. Mackay, Fabio Morgante, Matthew S. Geisz, Junwu Ma
Publikováno v:
Genome Research. 30:392-405
How effects of DNA sequence variants are transmitted through intermediate endophenotypes to modulate organismal traits remains a central question in quantitative genetics. This problem can be addressed through a systems approach in a population in wh
Publikováno v:
Learn Mem
Clinical and preclinical studies that have examined the neurobiology of persistent fear memory in posttraumatic stress disorder (PTSD) have focused on the medial prefrontal cortex, hippocampus, and amygdala. Sensory systems, the periaqueductal gray (