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Publikováno v:
Drug and Therapeutics Bulletin. 59:185-188
The US Food and Drug Administration (FDA) has approved two drugs for ‘hypoactive sexual desire disorder’ in women, flibanserin (Addyi) in 2015 and bremelanotide (Vyleesi) in 2019. In this paper we examine the outcome measures and clinical trial d
Autor:
Melissa Mercincavage, Anupreet K. Sidhu, Valentina Souprountchouk, Cristine D. Delnevo, Sasha Rogelberg, Andrew A. Strasser, Andrea C Johnson
Publikováno v:
Tobacco Control. 32:366-374
ObjectiveTo systematically review the literature regarding responses to commercial and public health marketing features for reduced nicotine cigarettes (RNCs) to anticipate potential industry and regulatory actions should an RNC product standard be i
Autor:
J Garg, Analia Alvarez, Elizabeth Zuta-Santillan, Paul Brunetta, Ana Malvar, Cary M. Looney, Brad H. Rovin, Thomas Schindler, Richard Furie, Matthew D Cascino, Imran Hassan, Gustavo Aroca, Hilda Fragoso-Loyo
Publikováno v:
Annals of the Rheumatic Diseases
ObjectiveRandomised trials of type I anti-CD20 antibodies rituximab and ocrelizumab failed to show benefit in proliferative lupus nephritis (LN). We compared obinutuzumab, a humanised type II anti-CD20 monoclonal antibody that induces potent B-cell d
Autor:
Richard Beasley, Christina Baggott, Jenny Sparks, Jo Hardy, Mark Weatherall, James Fingleton, Doñah Sabbagh
Publikováno v:
Thorax. 77:563-572
BackgroundInternational asthma guidelines recommend against epinephrine (adrenaline) administration in acute asthma unless associated with anaphylaxis or angio-oedema. However, administration of intramuscular epinephrine in addition to nebulised sele
Autor:
Helena Frndova, Nadia Roumeliotis, Christopher S. Parshuram, Eleanor Pullenayegum, Paula A. Rochon, Anna Taddio
Publikováno v:
Archives of Disease in Childhood. 107:388-393
ObjectiveAcetaminophen is the most common medication prescribed in children’s hospitals. The aim of the study was to estimate the frequency and risk factors for acetaminophen underdosing and overdosing in the paediatric intensive care unit (PICU).D
Autor:
Robert J. McCarthy, Asokumar Buvanendran, Ashley Meng Adams, Pete L Pelletier, Wendy Jo Kreider, Amanda C Sremac
Publikováno v:
Regional Anesthesia & Pain Medicine. 46:1067-1075
IntroductionDescriptions of opioid use trajectories and their association with postsurgical pain and opioid consumption are limited. We hypothesized that trajectories of opioid consumption in the first 28 days following surgery would be associated wi
Publikováno v:
Tobacco Control. 32:302-307
BackgroundResearch is inconclusive on the effectiveness of electronic nicotine delivery systems (ENDS) as cigarette cessation aids compared with nicotine replacement therapy (NRT) or non-NRT medication. This study compared the cigarette cessation rat
Autor:
Cian Hughes, Ronald A. Cantrell, Ching-Yi Chuo, Wen Hwa Lee, Dun Jack Fu, Susan P Mollan, Alastair K Denniston, J Jill Hopkins, Jacqueline G Gannon, Pearse A. Keane
Publikováno v:
British Journal of Ophthalmology. 107:267-274
ObjectivePredicting the impact of neovascular age-related macular degeneration (nAMD) service disruption on visual outcomes following national lockdown in the UK to contain SARS-CoV-2.Methods and analysisThis retrospective cohort study includes deide
Publikováno v:
European Journal of Hospital Pharmacy. 30:3-8
To investigate the efficacy and safety of programmed cell death 1 (PD-1)/programmed cell death-ligand 1 (PD-L1) plus cytotoxic T lymphocyte antigen-4 (CTLA-4) antibodies ± other therapies in patients with advanced lung cancer.In accordance with the
Autor:
Gertjan Wolbink, Radboud J E M Dolhain, Hieronymus T W Smeele, Erik Kemper, Theo Rispens, Ineke Hubertina Crijns, Nafise Ghalandari
Publikováno v:
Annals of the Rheumatic Diseases, 81(3), 402-405. BMJ Publishing Group
Annals of the rheumatic diseases, 81(3), 402-405. BMJ Publishing Group
Ghalandari, N, Kemper, E, Crijns, I H, Wolbink, G, Rispens, T, Smeele, H T & Dolhain, R J 2022, ' Analysing cord blood levels of TNF inhibitors to validate the EULAR points to consider for TNF inhibitor use during pregnancy ', Annals of the Rheumatic Diseases, vol. 81, no. 3, pp. 402-405 . https://doi.org/10.1136/annrheumdis-2021-221036
Annals of the rheumatic diseases, 81(3), 402-405. BMJ Publishing Group
Ghalandari, N, Kemper, E, Crijns, I H, Wolbink, G, Rispens, T, Smeele, H T & Dolhain, R J 2022, ' Analysing cord blood levels of TNF inhibitors to validate the EULAR points to consider for TNF inhibitor use during pregnancy ', Annals of the Rheumatic Diseases, vol. 81, no. 3, pp. 402-405 . https://doi.org/10.1136/annrheumdis-2021-221036
Background: Increasing evidence suggests that TNF inhibitors (TNFi) are safe to use during pregnancy1. A drawback of TNFi use during pregnancy is active transport across the placenta, which is affected by the structure of the TNFi1. The European Leag