Zobrazeno 1 - 10
of 39
pro vyhledávání: ''
Autor:
Isabelle S. Csete, Ross L. Levine, Qi Gao, Alexander Chan, Andriy Derkach, Maximilian Stahl, Sheng F. Cai, Jinjuan Yao, Tanmay Mishra, Richard Koche, Sophia Yanis, Martin S. Tallman, Aaron D Goldberg, Michael R. Waarts, Raajit K. Rampal, Ahmet Dogan, Robert L. Bowman, Minal Patel, Ying Liu, Wenbin Xiao, Mikhail Roshal, Maria E. Arcila, Jeeyeon Baik, Nicole L. DelGaudio, Christopher Famulare, Yanming Zhang
Publikováno v:
Blood
Plasmacytoid dendritic cells (pDCs) are the principal natural type I interferon–producing dendritic cells. Neoplastic expansion of pDCs and pDC precursors leads to blastic plasmacytoid dendritic cell neoplasm (BPDCN), and clonal expansion of mature
Autor:
Mohammad Hadigol, Jo Anne Vergilio, Anthony Fratella-Calabrese, Caitlin F. Connelly, Vincent A. Miller, Eric Allan Severson, Kim M. Hirshfield, Jeffrey S. Ross, Mendel Goldfinger, Shakti H. Ramkissoon, Garrett M. Frampton, Gregory Riedlinger, Shridar Ganesan, Siraj M. Ali, Lorna Rodriguez-Rodriguez, Hossein Khiabanian, Julia A. Elvin
Publikováno v:
Blood. 131:2501-2505
TO THE EDITOR: Clonal hematopoiesis of indeterminate potential (CHIP) describes an expansion of hematopoietic stem cells that harbor somatic mutations[1][1][⇓][2][⇓][3][⇓][4]-[5][5] without an underlying hematologic malignancy or definitive mor
Autor:
Christina Bamia, Maria Gkotzamanidou, Nikhil C. Munshi, Meletios A. Dimopoulos, Vassilis L. Souliotis, Evangelos Terpos
Publikováno v:
Blood. 128:1214-1225
DNA repair activity of malignant cells seems to influence therapeutic outcome and patients' survival. Herein, we investigated the mechanistic basis for the link between DNA repair efficiency and response to antimyeloma therapy. Nucleotide excision re
Autor:
Yves Gareau, Anne Marinier, Céline Moison, Sébastien Lemieux, Melanie Frechette, Nadine Mayotte, Josée Hébert, Bernhard Lehnertz, Sophie Corneau, Clarisse Thiollier, Vincent-Philippe Lavallée, Sylvie Lavallée, Guy Sauvageau, Valérie Blouin-Chagnon, Isabel Boivin
Patients diagnosed with acute myeloid leukemia with complex karyotype (CK AML) have an adverse prognosis using current therapies, especially when accompanied by TP53 alterations. We hereby report the RNA-sequencing analysis of the 68 CK AML samples i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00697bb66918b959818f0104841e330
https://europepmc.org/articles/PMC6391664/
https://europepmc.org/articles/PMC6391664/
Autor:
Wei Wang, Pei Lin, Hagop M. Kantarjian, Michael W. Beaty, Jorge E. Cortes, Shimin Hu, L. Jeffrey Medeiros, Timothy J. McDonnell, Di Ai, Hesham M. Amin, Chi Young Ok
Publikováno v:
Blood. 126:1699-1706
Chromosome 3q26.2 abnormalities in acute myeloid leukemia, including inv(3)/t(3;3) and t(3;21), have been studied and are associated with a poor prognosis. Their prevalence, response to tyrosine kinase inhibitor (TKI) treatment, and prognostic signif
Autor:
Maria E. Arcila, Christian A. Bowers, Eli L. Diamond, Benjamin H. Durham, Lynn A. Brody, Omar Abdel-Wahab, Ahmet Dogan, Neval Ozkaya, Mark Fluchel
Publikováno v:
Blood. 128:1896-1898
To the editor: Erdheim-Chester disease (ECD) is a myeloid neoplasm characterized by recurrent mutations in mitogen-activated protein kinase pathway genes, including BRAF , ARAF , N/KRAS , MAP2K1 , and PIK3CA mutations and fusions in ALK and NTRK1 .[1
Autor:
S.Z. Fields, Sarah E. Fordham, Ruth Plummer, Deepali Pal, Graham Jackson, Yvette Drew, Claire Elstob, Catherine Park, John Pollard, Gail Jones, David Jamieson, James M. Allan, Olaf Heidenreich, Paul Milne, Helen J. Blair, Helen Marr, Nicola J. Curtin, Tobias Menne
The ataxia telangiectasia and Rad3-related (ATR) protein kinase promotes cancer cell survival by signaling stalled replication forks generated by replication stress, a common feature of many cancers including acute myeloid leukemia (AML). Here we sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93da8d7a9d0ceea4d91a70465c35e73a
https://nrl.northumbria.ac.uk/id/eprint/38323/1/1157.full.pdf
https://nrl.northumbria.ac.uk/id/eprint/38323/1/1157.full.pdf
Autor:
Laura Z. Rassenti, John G. Gribben, Conor J. O’Donovan, Fabienne McClanahan, Sarah J. Kingdon, Andrew Clear, John Riches, Carlo M. Croce, Lillian Werner, Thomas J. Kipps, Donna Neuberg, Alan G. Ramsay
Publikováno v:
Blood. 123:4101-4110
The leukocyte adhesion cascade is important in chronic lymphocytic leukemia (CLL), as it controls migration of malignant cells into the pro-survival lymph node microenvironment. Circulating trisomy 12 CLL cells have increased expression of the integr
Autor:
Ya-Huei Kuo, Ravi Bhatia, Hongjun Liu, Yin Wei Ho, Tinisha McDonald, Stephen J. Forman, Cedric Dos Santos, Allen Lin
Publikováno v:
Blood. 122:1900-1913
The SRC family kinases (SFKs) and the receptor tyrosine kinase c-Kit are activated in human acute myeloid leukemia (AML) cells. We show here that the SFKs LYN, HCK, or FGR are overexpressed and activated in AML progenitor cells. Treatment with the SF
Autor:
Philippe Solal-Celigny, Martin Weisser, Ru-Fang Yeh, Tobias Benthaus, Gudrun Mellert, John Catalano, Wolfgang Hiddemann, Stefan K. Bohlander, Debraj GuhaThakurta, Guillemette Duchateau-Nguyen, Purvi M. Kakadia, Tadeusz Robak, Lin Wu, Evelyn Zellmeier, Marco Montillo, Sabine Lohmann, David Dornan, Nancy Patten, Christian H. Geisler, Sim Truong, Giuseppe Palermo, Stephanie Schneider, Jan Braess, Galina Salogub, Annika Dufour, Anna Dmoszynska, Karsten Spiekermann
Publikováno v:
Blood. 121:3650-3657
In chronic lymphocytic leukemia (CLL) patients, disruptions of the TP53 tumor suppressor pathway by 17p13 deletion (del17p), somatic TP53 mutations, or downregulation of microRNA-34a have been associated with a poor prognosis. So far, the impact of t