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Publikováno v:
J Virol
Viral antagonism of innate immune pathways is a common mechanism by which viruses evade immune surveillance. Infection of host cells with reovirus leads to the blockade of NF-{kappa}B, a key transcriptional regulator of the hosts innate immune respon
Autor:
Abhijit Chowdhury, Simanti Datta, Gopal Krishna Dhali, Filip Kalčic, Saikat Chakrabarti, Soma Banerjee, Rajiv Kumar Mondal, Ayana Baidya, Zlatko Janeba, Mousumi Khatun, Krishna Kumar, Ondřej Baszczyňski, Kausik S. Das
Publikováno v:
J Virol
Nucleos(t)ide analogues entecavir (ETV) and tenofovir disoproxil fumarate (TDF) are recommended as first-line monotherapies for chronic hepatitis B (CHB). Multiple HBV genotypes/subgenotypes have been described, but their impact on treatment response
Autor:
Eugene L. Stewart, Mark R. Underwood, Joseph Horton, Michael Aboud, Keith Nangle, Judy Hopking, Kimberly Y. Smith, Ruolan Wang, Brian Wynne, Jörg Sievers
Publikováno v:
Antimicrobial Agents and Chemotherapy
At week 48 in the phase IIIb DAWNING study, the integrase strand transfer inhibitor (INSTI) dolutegravir plus 2 nucleoside reverse transcriptase inhibitors demonstrated superiority to ritonavir-boosted lopinavir in achieving virologic suppression in
Autor:
Michael A. Parniak, Philip R. Tedbury, Stefan G. Sarafianos, Aaron B. Reeve, Eva Nagy, Tatiana V Ilina, Maria E. Cilento, Eleftherios Michailidis, Hiroaki Mitsuya
Publikováno v:
Antimicrob Agents Chemother
4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA, MK-8591, islatravir) is a nucleoside reverse transcriptase translocation inhibitor (NRTTI) with exceptional potency against wild-type (WT) and drug-resistant HIV-1 in phase III clinical trials. EFdA re
Autor:
Ernest Asante-Appiah, Dongmei Yang, Elizabeth Martin, Peter Sklar, Christos J. Petropoulos, Jay A. Grobler, Johnny Lai, Daria J. Hazuda, Charles M Walworth, Hong Wan
Publikováno v:
Antimicrobial Agents and Chemotherapy
Clinical management of human immunodeficiency virus type-1 (HIV-1) infection may be negatively impacted by either acquired or transmitted drug resistance. Here, we aim to extend our understanding of the impact of resistance-associated mutations (RAMs
Autor:
Melanie Lehoux, Perrin Baker, Natalie C. Bamford, Donald C. Sheppard, Caitlin A. Zacharias, Fabrice N. Gravelat, P. Lynne Howell, Ira Lacdao, Hanna Ostapska, Deepa Raju, Piyanka Sivarajah, Stephanie Gilbert, Thi Tuyet Mai Nguyen
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
Aspergillus fumigatus is a ubiquitous mold that can cause invasive pulmonary infections in immunocompromised patients. Within the lung, A. fumigatus forms biofilms that can enhance resistance to antifungals and immune defenses. Aspergillus biofilm fo
Autor:
Qiongyu Chen, Nathan E. Lewis, Charlotte B. Spliid, Jeffrey D. Esko, Nissi Varki, Alex Marki, Raquel J Riley, Dzung T. Le, Alejandro Gomez Toledo, Gregory J. Golden, Christofer Karlsson, James T. Sorrentino, Klaus Ley, Johan Malmström, Victor Nizet, Claire Morris, Ingrid Cornax
Publikováno v:
mBio, vol 12, iss 5
mBio, Vol 12, Iss 5 (2021)
mBio
mBio, Vol 12, Iss 5 (2021)
mBio
Hepatic failure is an important risk factor for poor outcome in septic patients. Using a chemical tagging workflow and high-resolution mass spectrometry, we demonstrate that rapid proteome remodeling of the vascular surfaces precedes hepatic damage i
Autor:
Marketa Koberska, Jana Vesela, Zdenek Kamenik, Vladimir Vimberg, Gabriela Balikova Novotna, Jiri Janata, Jakub Lenart, Ludmila Vesela
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
mBio
mBio
In natural environments, antibiotics are important means of interspecies competition. At subinhibitory concentrations, they act as cues or signals inducing antibiotic production; however, our knowledge of well-documented antibiotic-based sensing syst
Autor:
Feng Yang, Cheng Zhen, Vladimir Gritsenko, Yaniv Slor Futterman, Hui Lu, Judith Berman, Yuan-Ying Jiang, Lu Gao
Publikováno v:
mBio
mBio, Vol 12, Iss 4 (2021)
mBio, Vol 12, Iss 4 (2021)
How cells exposed to one stress are later able to better survive other types of stress is not well understood. In eukaryotic organisms, physiological and pathological stresses can disturb endoplasmic reticulum (ER) function, resulting in “ER stress
Autor:
Ram Prasad Awal, Patrick A. Haack, Chantal D. Bader, Cornelius N. Riese, Dirk Schüler, Rolf Müller
Publikováno v:
mBio, Vol 12, Iss 3 (2021)
mBio
bioRxiv
mBio
bioRxiv
Genomic information from various magnetotactic bacteria suggested that besides their common ability to form magnetosomes they potentially also represent a source of bioactive natural products. By using targeted deletion and transcriptional activation