Zobrazeno 1 - 10
of 13
pro vyhledávání: ''
Autor:
George C. Tsokos, Rhea Bhargava, Kayaho Maeda, Isaac E. Stillman, Maria Tsokos, Sylvain Lehoux, Suzanne Krishfield, Martin R. Pollak, Richard D. Cummings, Lena Ellezian
Publikováno v:
JCI Insight
JCI Insight, Vol 6, Iss 9 (2021)
JCI Insight, Vol 6, Iss 9 (2021)
Lupus nephritis (LN) is a serious complication occurring in 50% of patients with systemic lupus erythematosus (SLE) for which there is a lack of biomarkers, a lack of specific medications, and a lack of a clear understanding of its pathogenesis. The
Autor:
Gregory N. Fuller, Anantha Marisetty, Lauren A. Langford, Frederick F. Lang, Ganesh Rao, Jun Wei, Martina Ott, Maya Duna, Michael A. Curran, Carmen Jacobs, Raymond Sawaya, Shulin Li, Karl Heinz Tomaszowski, Jian Hu, Jason T. Huse, Amy B. Heimberger, Sujit S. Prabhu, Xiaorong Ji, James P. Long, Sherise D. Ferguson, Katia Blumberg, Jeffrey S. Weinberg, Ling Yuan Kong
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 17 (2020)
JCI Insight, Vol 5, Iss 17 (2020)
In order to prioritize available immune therapeutics, immune profiling across glioma grades was conducted, followed by preclinical determinations of therapeutic effect in immune-competent mice harboring gliomas. T cells and myeloid cells were isolate
Autor:
Matthew F. Krummel, Adil Daud, Kelly M. Mahuron, Michael Rosenblum, Zheng Liu, Isaac M. Neuhaus, Keyon Taravati, Richard Ahn, Tiffany C. Scharschmidt, Uk Sok Shin, Wilson Liao, Priscila Munoz Sandoval, David N. Nguyen, Gillian A. Kingsbury, Robert Rodriguez, Sarah T. Arron, Esther A. Kim, Kathrin Schumann, Hobart W. Harris, Mariela L. Pauli, Margaret M. Lowe, Ian C. Boothby, Alexander Marson, Sean Clancy
Publikováno v:
JCI insight, vol 4, iss 24
Distinct subsets of Tregs reside in nonlymphoid tissues where they mediate unique functions. To interrogate the biology of tissue Tregs in human health and disease, we phenotypically and functionally compared healthy skin Tregs with those in peripher
Autor:
Marco Klinger, Stefania Vetrano, Biagio Di Lorenzo, Michele Carvello, Anna Villa, Marita Bosticardo, Silvio Danese, Massimo Roncalli, Francesco Dieli, Antonino Spinelli, Elena Bruni, Ileana Bortolomai, Alessandra Roberto, Matteo Sacchi, Bruno Silva-Santos, Immo Prinz, Federico Colombo, Ferdinando Oriolo, Elena Lo Presti, Paola Spaggiari, Giovanni Cugini, Emanuela Marcenaro, Giovanni Colombo, Joanna Mikulak, Sarina Ravens, Serena Meraviglia, Domenico Mavilio, Silvia Della Bella
γδ T cells account for a large fraction of human intestinal intraepithelial lymphocytes (IELs) endowed with potent anti-tumor activities. However, little is known about their origin, phenotype and clinical relevance in colorectal cancer (CRC). To d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1e3fbd8fd94fdf6ed061ea76ae26eb
https://europepmc.org/articles/PMC6975269/
https://europepmc.org/articles/PMC6975269/
Autor:
Chao Shi, XiuJuan Shi, Chen Liu, Fang Su, Andrew Huynh, Yuan Ji, Yan-ming Wu, Terra-Dawn M. Plank, Miles F. Wilkinson, Guang Yang, ShuaiJun Li, YanJun Lu, Bo Zhu, JingWei Lu
Publikováno v:
The Journal of clinical investigation, vol 126, iss 8
Inflammatory myofibroblastic tumors (IMTs) are characterized by myofibroblast proliferation and an inflammatory cell infiltrate. Little is known about the molecular pathways that precipitate IMT formation. Here, we report the identification of somati
Autor:
Enli Liu, Zhuyong Mei, Hao Liu, Rammurti T. Kamble, Bambi Grilley, Barbara Savoldo, Helen E. Heslop, Malcolm K. Brenner, Brandon Ballard, Huimin Zhang, Gianpietro Dotti, Olga Dakhova, Adrian P. Gee, George Carrum, Meng Fen Wu, Cliona M. Rooney, Vicky Torrano, Carlos A. Ramos
Publikováno v:
Journal of Clinical Investigation. 126:2588-2596
BACKGROUND. Treatment of B cell malignancies with adoptive transfer of T cells with a CD19-specific chimeric antigen receptor (CAR) shows remarkable clinical efficacy. However, long-term persistence of T cells targeting CD19, a pan–B cell marker, a
Autor:
Yoshiko Sato, Minoru Fukuda, Akira Shiota, Junya Masumoto, Shinichi Miyagawa, Masatsugu Ueda, Michiko N. Fukuda, Fumitoshi Karasawa, Takashi Muraki, Motohiro Kobayashi, Jun Nakayama, Shuichi Yokosawa, Kazuhiko Ishihara, Maiko Fujiwara, Yukinobu Goso
Publikováno v:
Journal of Clinical Investigation. 122:923-934
信州大学博士(医学)・学位論文・平成24年3月31日授与(甲第916号)・唐澤文寿
Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having te
Gastric gland mucin secreted from the lower portion of the gastric mucosa contains unique O-linked oligosaccharides (O-glycans) having te
Autor:
Raymond L. Mernaugh, Kenneth E. Bernstein, Mohamed A. Saleh, Daniel W. Trott, Ana Paula Faria, Yu Shyr, Sheau-Chiann Chen, Wei Chen, Annet Kirabo, Christi L Galindo, Jing Wu, Liang Xiao, Xiao Z. Shen, Kalyani Amarnath, Meena S. Madhur, Cheryl L. Laffer, Venkataraman Amarnath, Vanessa Fontana, Fernando Elijovich, Tomasz J. Guzik, L. Jackson Roberts, Hana A. Itani, Heitor Moreno, Roxana Loperena, Alfiya T Bikineyeva, David G. Harrison, Sean S. Davies, Sergey Dikalov, Antony Vinh
Oxidative damage and inflammation are both implicated in the genesis of hypertension; however, the mechanisms by which these stimuli promote hypertension are not fully understood. Here, we have described a pathway in which hypertensive stimuli promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8b65bcf3f8da41cfefdfddff98b593c
https://europepmc.org/articles/PMC4220659/
https://europepmc.org/articles/PMC4220659/
Autor:
Imke Tiede, Kai Hildner, Radovan Dvorsky, Christoph Becker, Peter R. Galle, Heiko Iven, Stefan Wirtz, Brigitte Bartsch, Susanne Strand, Jonas Mudter, Markus F. Neurath, Daniela Poppe, Gerhard Fritz, Martin H. Holtmann, Mohammad Reza Ahmadian, Dennis Strand, Hans A. Lehr, Raja Atreya, Richard S. Blumberg, Henning Walczak
Publikováno v:
Journal of Clinical Investigation. 111:1133-1145
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that are used in organ transplantation and autoimmune and chronic inflammatory diseases such as Crohn disease. However, their molecular mechanism of action is unknown
Autor:
H Michalaki, Andreas Mackensen, S. Viel, Thierry Hercend, M C Raynal, G. Carcelain, F. Triebel, J Bosq
Publikováno v:
Journal of Clinical Investigation. 93:1397-1402
The concept of immunosurveillance against cancer has been an extensively debated question over the last decades. Multiple indirect arguments have supported the view that the immune system may control, at least in certain cases, malignant cell growth