Zobrazeno 1 - 10
of 100
pro vyhledávání: ''
Autor:
Patel, Manali I., Kapphahn, Kristopher, Dewland, Marilyn, Aguilar, Veronica, Sanchez, Blanca, Sisay, Etsegenet, Murillo, Ariana, Smith, Kim, Park, David J.
Publikováno v:
JAMA Oncol
IMPORTANCE: Deficiencies in advance care planning and symptom management are associated with avoidable acute care use among patients with cancer. Community health worker (CHW)–led approaches may be an approach to reduce acute care use but remain un
Autor:
Alexander Stein, Lisa Paschold, Joseph Tintelnot, Eray Goekkurt, Svenja-Sibylla Henkes, Donjete Simnica, Christoph Schultheiss, Edith Willscher, Marcus Bauer, Claudia Wickenhauser, Peter Thuss-Patience, Sylvie Lorenzen, Thomas Ettrich, Jorge Riera-Knorrenschild, Lutz Jacobasch, Albrecht Kretzschmar, Stefan Kubicka, Salah-Eddin Al-Batran, Anke Reinacher-Schick, Daniel Pink, Marianne Sinn, Udo Lindig, Wolfgang Hiegl, Axel Hinke, Susanna Hegewisch-Becker, Mascha Binder
Publikováno v:
JAMA Oncology.
In metastatic esophagogastric adenocarcinoma (EGA), the addition of programmed cell death 1 (PD-1) inhibitors to chemotherapy has improved outcomes in selected patient populations.To investigate the efficacy of trastuzumab and PD-1 inhibitors with cy
Autor:
Jiachen, Xu, Zheng, Liu, Hua, Bai, Guilan, Dong, Jia, Zhong, Rui, Wan, Aiming, Zang, Xiaoling, Li, Qingshan, Li, Jun, Guo, Nan, Du, Diansheng, Zhong, Yan, Huang, Qun, Lv, Jinghua, Zhang, Yue, Zhao, Liming, Gao, Lin, Li, Chunyi, Zhang, Jun, Zhao, Baolan, Li, Zhe, Liu, Zhenlin, Yang, Dong, Ji, Tao, Wang, Jianchun, Duan, Zhijie, Wang, Jie, Wang
Publikováno v:
JAMA Oncology. 8:1328
ImportanceThe inability to obtain a pathological diagnosis in a certain proportion of patients with clinically diagnosed advanced lung cancer impedes precision treatment in clinical practice.ObjectiveTo evaluate the clinical outcome of first-line ico
Autor:
Matthew H. G. Katz, Qian Shi, Jeff Meyers, Joseph M. Herman, Michael Chuong, Brian M. Wolpin, Syed Ahmad, Robert Marsh, Larry Schwartz, Spencer Behr, Wendy L. Frankel, Eric Collisson, James Leenstra, Terence M. Williams, Gina Vaccaro, Alan Venook, Jeffrey A. Meyerhardt, Eileen M. O’Reilly
Publikováno v:
JAMA Oncology. 8:1263
ImportanceNational guidelines endorse treatment with neoadjuvant therapy for borderline resectable pancreatic ductal adenocarcinoma (PDAC), but the optimal strategy remains unclear.ObjectiveTo compare treatment with neoadjuvant modified FOLFIRINOX (m
Autor:
Xavier, Pivot, M A, Georgievich, Volodymyr, Shamrai, Giorgi, Dzagnidze, Hwoei Fen, Soo Hoo, Viriya, Kaewkangsadan, Fausto, Petrelli, Cristian, Villanueva, Lipatov O, Nikolaevich, Jocelyn, Hii, Jamie, Kim, Sumita, Pradhan, Litha, Jaison, Peggy, Feyaerts, Leonard, Kaufman, Marie-Paule, Derde, Ghislain M C, Bonamy, Filip, Deforce, David G, Cox
Publikováno v:
JAMA Oncol
The drug HD201 is a biosimilar candidate for breast cancer treatment as the reference trastuzumab.To compare the efficacy of HD201 with referent trastuzumab.This randomized clinical trial (TROIKA) included 502 women with ERBB2-positive early breast c
Autor:
C Jillian, Tsai, Sean M, McBride, Nadeem, Riaz, Jung J, Kang, Daniel J, Spielsinger, Todd, Waldenberg, Daphna, Gelblum, Yao, Yu, Linda C, Chen, Kaveh, Zakeri, Richard J, Wong, Lara, Dunn, David G, Pfister, Eric J, Sherman, Nancy Y, Lee
Publikováno v:
JAMA Oncology. 8:364
Several de-escalation strategies for human papillomavirus (HPV)-associated oropharyngeal carcinoma (OPC) have focused on deintensifying gross disease treatment. Reduction of radiotherapy dose and target volume to subclinical regions may achieve good
Autor:
Nicholas G. Zaorsky, Kimberly A. Hochstedler, Daniel E. Spratt, Ming Wang, Xi Wang, Madeline R. Abbott, Robert T. Dess, Emily Morris, Neil K. Jairath, Matthew J. Schipper, Theresa Devasia, Kelley M. Kidwell, William C. Jackson, Vonn Walter, Yilun Sun, Elizabeth C Chase, Holly E. Hartman, Pin Li
Publikováno v:
JAMA Oncology
JAMA Oncol
JAMA Oncol
Importance Cancer treatment delay has been reported to variably impact cancer-specific survival and coronavirus disease 2019 (COVID-19)-specific mortality during the severe acute respiratory syndrome coronavirus 2 pandemic. During the pandemic, treat
Publikováno v:
JAMA Oncology
JAMA Oncol
JAMA Oncol
This prospective observational study assesses changes in treatment plans for patients with lung cancer and qualifies the types of changes observed as a direct result of the coronavirus disease 2019 pandemic.
Autor:
Jiping Wang, Nadine Jackson McCleary, Ugwuji N. Maduekwe, Brian M. Wolpin, Winta T. Mehtsun, Deborah Schrag
Publikováno v:
JAMA Oncol
IMPORTANCE: Patients 80 years and older with pancreatic ductal adenocarcinoma (PDAC) have not consistently received treatments that have established benefits in younger older adults (aged 60-79 years), yet patients 80 years and older are increasingly
Autor:
Yinghong Wang, Pamela Pizzutilo, Marco Filetti, Amin Nassar, Carolyn J Presley, Christopher J. Hoimes, Paolo A. Ascierto, Sebastiano Buti, Andrea Botticelli, Domenico Mallardo, Haocan Song, Maria Giovanna Dal Bello, Caroline A. Nebhan, Neha Debnath, Foteini Kalofonou, Melissa Bersanelli, Giuseppe Lamberti, Carlo Genova, Thomas U. Marron, Ella Daniels, Vito Vanella, Douglas B. Johnson, Annamaria Catino, Nikhil H. Ramaiya, Rebecca Irlmeier, Raffaele Giusti, Anwaar Saeed, Tamara A. Sussman, Biagio Ricciuti, Dwight H. Owen, Maluki Radford, Toni K. Choueiri, Chiara Casartelli, Domenico Galetta, Shravanti Macherla, David J. Pinato, Paolo Marchetti, Alessio Cortellini, Weijie Ma, Sarah Abou Alaiwi, Fei Ye, Akiva Diamond, Abdul Rafeh Naqash, Asrar Alahmadi, Teja Ganta
Publikováno v:
JAMA Oncol
IMPORTANCE: Geriatric (aged ≥80 years) patients are historically underrepresented in cancer clinical trials. Little is known about the efficacy of immune checkpoint inhibitors (ICIs) in geriatric patients. These agents are associated with immune-re