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Publikováno v:
Cancer Research. 83:398-398
The leading cause of cancer-related death among women worldwide is breast cancer. The triple-negative breast cancer (TNBC) subtype has limited therapeutic options that produce durable responses. As a result, it is associated with an especially poor p
Autor:
Jitender Monga, Indra Adrianto, Craig Rogers, Shirish Gadgeel, Dhananjay Chitale, Jagadananda Ghosh
Publikováno v:
Cancer Research. 82:398-398
Background: About 33,000 men will die due to prostate cancer in the US in the year 2021. Prostate cancer initially responds to androgen receptor (AR) targeted therapies (e.g., enzalutamide, darolutamide). However, therapy-resistant, aggressive, letha
Publikováno v:
Cancer Research. 81:398-398
Purpose: Tumor mutational burden (TMB) is emerging as a promising biomarker in immune checkpoint inhibitor therapy. Although whole-exome sequencing (WES) is the gold standard to quantify TMB, most TMB measurements in routine diagnostic applications w
Publikováno v:
Cancer Research. 79:398-398
The Philadelphia chromosome (Ph) translocation, which leads to creation of a fusion gene product BCR-ABL, is found in chronic myelogenous leukemia (CML) and 20% of adult and 2-5% pediatric acute B-lymphoblastic leukemia (B-ALL). The selective ABL tyr
Autor:
Scott E. Martin, Richard Bourgon, Christiaan Klijn, Oleg Mayba, Michael R. Costa, Colin K. Watanabe, Siyu Feng, Bob Yauch, Russell Bainer, Eva Lin, Catherine Wilson, Marinella Callow
Publikováno v:
Cancer Research. 78:398-398
In response to diverse stimuli, tumor cells can undergo a process resembling the epithelial-mesenchymal transition (EMT) observed during development. During this transition, epithelial-like tumor cells acquire mesenchymal-like physiologic features, b
Publikováno v:
Cancer Research. 77:398-398
Background Copy number alterations are common driver mutations in cancer. Identifying genes which show altered copy number and knowing the breakpoints of copy number alterations gives insight into their functionality as well as the mechanisms respons
Publikováno v:
Cancer Research. 76:398-398
Introduction: Since 2002, PATH Foundation has kept a biobank collecting high-quality fresh frozen breast cancer specimens adhering to uniform SOPs at seven certified breast cancer centres in Germany. Research groups from academia and industry can obt
Publikováno v:
Cancer Research. 75:398-398
Background. Bone metastatic breast cancer promotes extensive bone destruction/osteolysis and is currently incurable. Progression of the disease is critically dependent on cancer-bone interaction. Defining the molecular mechanisms underlying this comm
Publikováno v:
Cancer Research. 74:398-398
INTRODUCTION Testis specific Y-like protein (TSPYL-5) is a member of TSPY-L family of gene, whose functions are currently unknown. TSPYL-5 was reported to possess tumor suppressor function and a target for epigenetic silencing in human glioblastoma a
Publikováno v:
Cancer Research. 73:398-398
Canine osteosarcoma is a common and highly aggressive cancer that shares many characteristics with human osteosarcoma and can serve as a model of this disease. We collected snap frozen normal muscle, primary appendicular skeleton tumour, and matched