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Autor:
Rafał Banasiuk, Wojciech Makowski, Ales Pecinka, Jana Zwyrtková, Krzysztof Tokarz, Aleksandra Królicka, Barbara Tokarz, Anna Nowicka
Publikováno v:
Applied Microbiology and Biotechnology
Abstract The Venus flytrap (Dionaea muscipula J. Ellis) is a carnivorous plant able to synthesize large amounts of phenolic compounds, such as phenylpropanoids, flavonoids, phenolic acids, and 1,4-naphtoquinones. In this study, the first genetic tran
Autor:
Vincent M. Carroll, Daniel Holden, Seth C. Hopkins, Kenneth S. Koblan, Robert Lew, Richard E. Carson, Cristian Constantinescu, Gerald Galluppi
Publikováno v:
Psychopharmacology
Rationale Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains uncle
Autor:
Jeremy E. Melanson, Garnet McRae
Publikováno v:
Analytical and Bioanalytical Chemistry
The increase in production of cannabis for medical and recreational purposes in recent years has led to a corresponding increase in laboratories performing cannabinoid analysis of cannabis and hemp. We have developed and validated a quantitative liqu
Autor:
Hendrik Schewe, Florence Miramella Schempp, Jia Mi, Ferdinand Kirchner, Markus Buchhaupt, Katharina Elisabeth Hofmann, Jens Schrader, Annika Meffert
Publikováno v:
Applied Microbiology and Biotechnology
Monoterpenoids are widely used in industrial applications, e.g. as active ingredients in pharmaceuticals, in flavor and fragrance compositions, and in agriculture. Severe toxic effects are known for some monoterpenoids making them challenging compoun
Autor:
Jessica Gierhake, Julian Droste, Alfred Pühler, Susanne Schneiker-Bekel, Lena Schaffert, Jörn Kalinowski, Marcus Persicke, Winfried Dipl Chem Dr Rosen
Publikováno v:
Applied Microbiology and Biotechnology
Actinoplanes sp. SE50/110 (ATCC 31044) is the wild type of industrial producer strains of acarbose. Acarbose has been used since the early 1990s as an inhibitor of intestinal human α-glucosidases in the medical treatment of type II diabetes mellitus
Autor:
Mario Lukacevic, Tobias Borchert, James T. Thackeray, Annika Hess, Frank M. Bengel, Tobias L. Ross
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging
Purpose Myocardial infarction (MI) triggers a local inflammatory response which orchestrates cardiac repair and contributes to concurrent neuroinflammation. Angiotensin-converting enzyme (ACE) inhibitor therapy not only attenuates cardiac remodeling
Autor:
Eric D Gardner, Bryce P. Johnson, Dustin A Dimas, Andrea L Batchev, Susan L. Nimmo, Tejaswi Bavineni, Shanteri Singh, Erin M. Scull, Chandrasekhar Bandari
Publikováno v:
Applied Microbiology and Biotechnology
Abstract Aromatic prenyltransferases are known for their extensive promiscuity toward aromatic acceptor substrates and their ability to form various carbon-carbon and carbon-heteroatom bonds. Of particular interest among the prenyltransferases is Nph
Autor:
Maura Dandri
Publikováno v:
Seminars in Immunopathology
The human hepatitis B virus (HBV) is a small-enveloped DNA virus causing acute and chronic hepatitis. Despite the existence of an effective prophylactic vaccine and the strong capacity of approved antiviral drugs to suppress viral replication, chroni
Autor:
Danuta Wojcieszyńska, Urszula Guzik
Publikováno v:
Applied Microbiology and Biotechnology
Abstract This article summarizes the current knowledge about the presence of naproxen in the environment, its toxicity to nontarget organisms and the microbial degradation of this drug. Currently, naproxen has been detected in all types of water, inc
Autor:
Franziska Hartung, Luis A. Pardo
Publikováno v:
European Biophysics Journal
Resisting cell death is one of the hallmarks of cancer, and represents a common problem resulting in ineffective cancer therapy. To overcome resistance to apoptosis, we designed an antibody-based therapy strategy using Kv10.1 as a target. Kv10.1 is a