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Publikováno v:
The Journal of Toxicological Sciences. 46:477-486
Objective To investigate the protective effect of MZF1/RBM3 on rotenone-induced neuronal injury. Methods Rotenone (1 μM) was used to treat SH-SY5Y cells for 24 hr to simulate the cellular model of Parkinson's disease (PD), followed by detection of S
Autor:
Hisayoshi Ohta, Kenichi Ohba
Publikováno v:
The Journal of Toxicological Sciences. 45:539-548
We investigated the mechanism underlying intestinal cadmium (Cd) uptake based on the mediators (metal transporters) of essential elements, such as Fe, Zn, Cu, and Ca, under normal conditions in female rats. These elements interact with Cd uptake from
Publikováno v:
The Journal of Toxicological Sciences. 44:737-751
Industry demand for nanomaterials is growing, but metal nanoparticle toxicity is not fully understood. For example, nickel nanoparticles (NiNPs) are used in electric capacitors, and their consumption is increasing, but there have been few reports of
Autor:
Mahendra K. Thakur, Dhiraj Kumar
Publikováno v:
The Journal of Toxicological Sciences. 42:281-289
Bisphenol-A (BPA) is an estrogenic endocrine disruptor mostly used for the production of polycarbonate plastics and epoxy resins. Recently we have reported that perinatal BPA exposure impaired spatial memory through upregulation of synaptic proteins
Evaluation of drug-induced hematotoxicity using novel in vitro monkey CFU-GM and BFU-E colony assays
Publikováno v:
The Journal of Toxicological Sciences. 42:397-405
In order to evaluate drug-induced hematotoxicity in monkey cells in vitro, colony-forming unit-granulocyte, macrophage (CFU-GM), and burst-forming unit-erythroid (BFU-E) colony assays were established using mononuclear cells in the bone marrow collec
Autor:
Brian G. Lake, Hashihiro Higuchi, Tomoya Yamada, Samuel M. Cohen, Satoshi Kawamura, Hiroko Kikumoto, Yoshimasa Nakamura, Masahiko Kushida, Yu Okuda
Publikováno v:
The Journal of Toxicological Sciences. 42:773-788
High dietary levels of the non-genotoxic synthetic pyrethroid momfluorothrin increased the incidence of hepatocellular tumors in male and female Wistar rats. Mechanistic studies have demonstrated that the mode of action (MOA) for momfluorothrin-induc
Autor:
Jens Broscheit, Norbert Roewer, Sergey Shityakov, Ramin Ekhteiari Salmas, Ellaine Salvador, Carola Förster
Publikováno v:
ResearcherID
King's College London
King's College London
In this study, we investigated the cytotoxic effects of unmodified α-cyclodextrin (α-CD) and modified cyclodextrins, including trimethyl-β-cyclodextrin (TRIMEB) and hydroxypropyl-β-cyclodextrin (HPβCD), on immortalized murine microvascular endot
Publikováno v:
The Journal of Toxicological Sciences. 40:365-373
Toxic and harmful factors co-exist in the environment; these factors often interact to induce combined toxicity, which is the main focus of toxicological research. Furthermore, a large number of studies have shown that aluminum (Al) and benzo[a]pyren
Autor:
Jin-Yong Lee, Yasuyuki Fujiwara, Shunji Imai, Masahiko Satoh, Maki Tokumoto, Hisamitsu Nagase, Yoshiyuki Seko, Akiko Honda, Tatsuya Hasegawa
Publikováno v:
The Journal of Toxicological Sciences. 39:173-177
We compared the cadmium (Cd) concentration in the liver and kidney of different strains of mice after exposure to 50 ppm Cd for 30 days via drinking water. Cd concentration in the liver and kidney of C57BL/6J mice were higher than those of 129/Sv and
Publikováno v:
The Journal of Toxicological Sciences. 39:735-738
Cadmium is a toxic heavy metal that causes severe clinical symptoms in various tissues including the kidney. In this study, activities of transcription factors were measured to identify what type of transcription factor was affected by cadmium in rat