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Autor:
Rene van Oerle, Natalie J Jooss, Linda Herfs, Yvonne M. C. Henskens, Johan W. M. Heemskerk, Mike Kozlowski, Patric Machiels, Floor C J I Heubel-Moenen, Frauke Swieringa
Publikováno v:
Thrombosis Research, 203, 46-56. Elsevier Science
Thrombosis Research
Thrombosis Research
Introduction: Current developments to assess qualitative and quantitative platelet traits in flowed whole-blood are based on microfluidic devices that mostly operate at room temperature. However, operation at physiological temperature (37 degrees;C)
Publikováno v:
Thrombosis Research. 196:510-515
Introduction On-treatment platelet aggregability represents the major form of functional assessment for patients treated with P2Y12 receptor antagonists, with “high” on-treatment platelet aggregability (HTPA) predicting thrombotic risk. However H
Publikováno v:
Thrombosis Research. 196:175-185
AMP-activated protein kinase (AMPK) is a metabolic master switch that has critical role in wide range of pathologies including cardiovascular disorders. As AMPK-α2 knockout mice exhibit impaired thrombus stability, we asked whether pharmacological i
Publikováno v:
Thrombosis Research. 195:87-94
Caffeic acid (CA) is a polyphenol widely distributed in the plant kingdom. Studies have shown CA possesses antithrombotic activity in mouse cerebral arterioles in vivo and inhibits platelet aggregation in vitro. However, little is known regarding the
Autor:
Tetsuya Maeda, Mie Shimizu, Makiko Yoshida, Tatsunori Natori, Yoko Ishigaku, Kazumasa Oura, Kiyotaka Oi, Shinsuke Narumi, Keisuke Tsuda, Asami Kamada, Yasuo Terayama
Publikováno v:
Thrombosis Research. 189:1-4
Publikováno v:
Thrombosis Research. 187:148-153
Growth differentiation factor-15 (GDF-15) has been identified as a predictor in cardiovascular diseases and acute pulmonary embolism. However, the association of GDF-15 and deep venous thrombosis (DVT) remains unclear. This study aimed to investigate
Publikováno v:
Thrombosis Research. 185:27-30
Introduction Whereas the utility of washed platelet assays such as the heparin-induced platelet activation test (HIPA) for the diagnosis of heparin-induced thrombocytopenia (HIT) is regarded as high, the performance of simpler assays such as the hepa
Autor:
Maria Jastrzębska, Barbara Dołęgowska, Anna Lebiecka, Jarosław Woźniak, Zuzanna Marcinowska, Marta Budkowska
Publikováno v:
Thrombosis Research. 182:79-88
In this paper we tested a group of 66 healthy volunteers in terms of the influence of circadian rhythm on selected parameters of the coagulation system and fibrinolytic system. Blood was collected at 6-hour intervals, at 8 am, 2 pm, 8 pm and 2 am. Ci
Publikováno v:
Thrombosis Research. 180:74-85
Background The incretin hormone Glucagon-like peptide 1(GLP-1) plays a pivotal role in maintaining glucose homeostasis with effects also on the cardiovascular system. GLP-1 influences platelet functions by increasing the inhibitory action of nitric o
Publikováno v:
Thrombosis Research. 180:55-61
Background Heparin-induced thrombocytopenia (HIT) is caused by platelet-activating antibodies that recognize platelet factor 4/heparin (PF4/hep)-complexes. The in vitro demonstration of PF4/hep antibodies using functional assays is essential for an o