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pro vyhledávání: ''
Autor:
Wei Han, Shiyuan Zhou, Yan-Rong Liu, Yuan Kong, Jingzhong Zhao, Jia-Min Zhang, Lan-Ping Xu, Yi Zhou, Qian-Ming Wang, Feng-Rong Wang, Min Wang, Huan Chen, Xiao-Hui Zhang, Fei-Er Feng, Xiao-Lu Zhu, Ya-Zhe Wang, Xiao-Jun Huang, Ru Feng, Kai-Yan Liu, Jing-Zhi Wang
Publikováno v:
Thrombosis Research. 139:1-9
Objectives The aim of this study was to investigate the role of prostacyclin (PGI 2 ) in prolonged isolated thrombocytopenia (PT) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the effect of PGI 2 on the activation and a
Publikováno v:
Thrombosis Research. 121:535-542
Platelets contain and release matrix metalloproteinases (MMPs), their inhibitors (TIMPs) and disintegrin metalloproteinases (ADAMs) including MMP-1, MMP-2, MMP-3, MMP-9, MT1-MMP (MMP-14), ADAM-10, ADAM-17, ADAMTS-13, TIMP-1, TIMP-2 and TIMP-4. These
Publikováno v:
Thrombosis Research. 98:451-459
Transforming growth factor-beta(1) released from platelet alpha-granules may preserve endothelial functions in injured vessels. However, direct evidence is lacking regarding how this cytokine modifies the antithrombotic function of injured endothelia
Autor:
Marı́a Isabel Ruiz-Ruiz, Felipe Sánchez de la Cuesta, Antonio Vallecillo Moreno, José Luis Pérez de la Cruz
Publikováno v:
Thrombosis Research. 97:125-131
Combined thromboxane synthase inhibitors and thromboxane receptors antagonists have been shown to have a beneficial effect on different models of thrombosis in vivo. We studied the action of one of these compounds (DT-TX 30) compared with dazoxiben (
Autor:
Dariusz Pawlak, Wlodzimierz Buczko, Ewa Chabielska, Roland Rólkowski, Janusz Golatowski, Pawlak R
Publikováno v:
Thrombosis Research. 90:271-278
The potential antithrombotic action of losartan, the AT1 receptor antagonist, in an experimental model of venous thrombosis in spontaneously hypertensive rats (SHR) and Wistar Kyoto rats (WKY) was tested. The involvement of nitric oxide and prostacyc
Autor:
E Blanco, José Pedro De La Cruz M, Felipe Sánchez de la Cuesta, Antonia Maximo, Antonio Vallecillo Moreno
Publikováno v:
Thrombosis Research. 86:515-524
We analyzed the in vitro effects of sorbitol and fructose on platelet function. Sorbitol and fructose increased platelet aggregation induced with adenosine diphosphate (ADP) or collagen in whole blood, but had no effect in platelet-rich plasma. The c
Publikováno v:
Thrombosis Research. 81:367-381
Cyclosporin A (CsA), a potent immunosuppressor used in organ transplants and autoimmune diseases, is associated with adverse effects in the kidney, liver, and nervous system. This drug was recently shown to stimulate platelet aggregation, to increase
The role of thromboxane A2 in increased whole blood platelet aggregation in oral contraceptive users
Publikováno v:
Thrombosis Research. 81:407-417
Epidemiological studies have shown that oral contraceptives increase the risk of thromboembolic disease in susceptible women however the mechanisms involved are unclear. We investigated whole blood platelet aggregation in 44 women randomly allocated
Publikováno v:
Thrombosis Research. 73:205-214
In this study we have investigated the effect of human mononuclear leukocytes (ML) on platelet aggregation. The results obtained demonstrated that coincubation of platelets with nonstimulated ML decreased platelet aggregation induced by collagen or t
Publikováno v:
Thrombosis Research. 70:405-415
The aim of our study was to evaluate the platelet antiaggregatory and hemodynamic effects of the stable prostacyclin analog iloprost and the NO-donor SIN-1, an active metabolite of molsidomine. The number of circulating platelets was determined in an