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Publikováno v:
Thrombosis Research. 191:57-65
Background There is a need to identify and develop novel thrombolytic agents that can directly digest fibrin clots from various biological resources. Objective To clone, express, purify, and characterize a recombinant protease named rvFMP capable of
Autor:
Alexander Choukèr, Markus Rehm, Lesca M. Holdt, Max C. Enzinger, Mathias Bruegel, Judith-Irina Buchheim
Publikováno v:
Thrombosis Research. 186:93-102
Introduction A functional vascular barrier controlling leukocyte recruitment into the perivascular space relies on an intact endothelial glycocalyx (EGX). Critical disease states such as sepsis or trauma can induce massive shedding of EGX components
Publikováno v:
Thrombosis Research. 180:74-85
Background The incretin hormone Glucagon-like peptide 1(GLP-1) plays a pivotal role in maintaining glucose homeostasis with effects also on the cardiovascular system. GLP-1 influences platelet functions by increasing the inhibitory action of nitric o
Publikováno v:
Thrombosis Research. 169:1-7
Lipoprotein(a) [Lp(a)] is an enigmatic lipoprotein which has been identified as a causal risk factor for coronary heart disease and calcific aortic valve disease. Lp(a) consists of a low-density lipoprotein (LDL) moiety covalently linked to the uniqu
Autor:
Saonli Basu, Lu-Chen Weng, Weihua Guan, Mary Cushman, Lyn M. Steffen, James S. Pankow, Aaron R. Folsom, Weihong Tang, Ming-Huei Chen, Nathan Pankratz
Publikováno v:
Thrombosis Research. 168:53-59
Introduction Data from epidemiological studies and clinical trials suggest an influence of dietary and circulating polyunsaturated fatty acids (PUFAs) on the hemostasis profile. Genome-wide association studies (GWAS) have identified single nucleotide
Platelet hyperactivation, apoptosis and hypercoagulability in patients with acute pulmonary embolism
Autor:
Michael A. Puskarich, Samin Rezania, Matthew T. Rondina, Jeffrey A. Kline, Evandro M. Neto-Neves, Daniela N. Petrusca
Publikováno v:
Thrombosis Research. 155:106-115
Changes in systemic redox balance can alter platelet activation and aggregation. Acute pulmonary embolism (PE) is a systematic inflammatory disease associated with mechanical shear stress, increased thrombin, catecholamines, serotonin and hemolysis,
Autor:
Vassili N. Lazarev, I. Baskova, Valentin A. Manuvera, D.N. Akhaev, P.A. Bobrovsky, S. Kalabushev
Publikováno v:
Thrombosis research. 165
Introduction Known thrombolytic agents either break peptide bonds in the fibrin molecule or act as plasminogen activators, which also results in peptide bond cleavage. In thrombi, fibrin molecules are known to be cross-linked by isopeptide bonds, the
Publikováno v:
Thrombosis Research. 134:111-120
Statins are widely used as hypolipidemic drugs, and have beneficial effects in reducing cardiovascular events. In addition, recent studies on the pleiotropic effects of statins (i.e., simvastatin) reveal that these drugs have many additional anti-ath
Autor:
Gerry A. F. Nicolaes, Olivier Sperandio, Roy Schrijver, Bruno O. Villoutreix, Karin C. A. A. Wildhagen, Simone J.H. Wielders
Publikováno v:
Thrombosis Research, 133(6), 1105-1114. Elsevier Science
Introduction Activated protein C (APC) is the central enzyme of the anticoagulant protein C pathway. Low concentrations of APC circulate in plasma and are believed to contribute to the maintenance of a normal haemostatic balance. Materials and Method
Autor:
Rong Yan, Yiwen Zhang, Pingping Zhang, Guanglei Liu, Juan Du, Jin Dai, Lili Zhao, Kesheng Dai, Feng Zhang, Xiujuan Wang
Publikováno v:
Thrombosis Research. 132:696-701
Background Glycoprotein (GP) Ibα contains binding sites for von Willebrand factor (VWF), α-thrombin, P-selectin, and Mac-1 at the extracellular N-terminal 282 residues. Particularly, the interaction of GPIbα with VWF exposed at the injured vessel