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Autor:
Rene van Oerle, Natalie J Jooss, Linda Herfs, Yvonne M. C. Henskens, Johan W. M. Heemskerk, Mike Kozlowski, Patric Machiels, Floor C J I Heubel-Moenen, Frauke Swieringa
Publikováno v:
Thrombosis Research, 203, 46-56. Elsevier Science
Thrombosis Research
Thrombosis Research
Introduction: Current developments to assess qualitative and quantitative platelet traits in flowed whole-blood are based on microfluidic devices that mostly operate at room temperature. However, operation at physiological temperature (37 degrees;C)
Autor:
Peter Busch-Østergren, Shivam Patel, Samuel Jaimian Church, Thomas W. Wakefield, Mackenzie Adams, James Henderson, Benjamin E. Tourdot, Adriana Yamaguchi, Tadas Kasputis, Ajjai Alva, Michael Holinstat, Aaron M. Udager, Zachery R. Reichert, Xiu Cao, Ganesh S. Palapattu, Alexander Zaslavsky, Samantha K. Lee, Sydney Ohl, Todd M. Morgan, Sethuramasundaram Pitchiaya
Publikováno v:
Thromb Res
INTRODUCTION: Despite the great promise for therapies using antisense oligonucleotides (ASOs), their adverse effects, which include pro-inflammatory effects and thrombocytopenia, have limited their use. Previously, these effects have been linked to t
Publikováno v:
Thrombosis Research. 196:510-515
Introduction On-treatment platelet aggregability represents the major form of functional assessment for patients treated with P2Y12 receptor antagonists, with “high” on-treatment platelet aggregability (HTPA) predicting thrombotic risk. However H
Publikováno v:
Thrombosis Research. 196:175-185
AMP-activated protein kinase (AMPK) is a metabolic master switch that has critical role in wide range of pathologies including cardiovascular disorders. As AMPK-α2 knockout mice exhibit impaired thrombus stability, we asked whether pharmacological i
Publikováno v:
Thrombosis Research. 195:87-94
Caffeic acid (CA) is a polyphenol widely distributed in the plant kingdom. Studies have shown CA possesses antithrombotic activity in mouse cerebral arterioles in vivo and inhibits platelet aggregation in vitro. However, little is known regarding the
Publikováno v:
Thrombosis Research. 193:15-21
Introduction Systemic hypercoagulation is often a severe complication of infective and inflammatory diseases, which overcome the hemostatic balance and lead to multiple thrombotic occlusions in the microvasculature and organ damage and is related to
Publikováno v:
Thrombosis Research. 187:186-196
Under normal conditions, the hemostatic system, that includes the involvement of the coagulation response and platelets, is anatomically and functionally inseparable from the vasculature. However, the hemostatic response always occurs in a wide range
Autor:
Jun Liu, Liuan Qin, Yangxun Wu, Jia Liu, Li Peng, Yuting Zou, Tong Yin, Rina Du, Ziqian Wang, Xuyun Wang
Publikováno v:
Thrombosis Research. 186:71-74
Autor:
Junjie Kou, Haijiao Jing, Jialan Shi, Jingwen Du, Chunxu Wang, Muxin Yu, Yayan Bi, Jin Zhou, Xinyi Zhao, Valerie A. Novakovic, Yueyue Li, Yan Zhang, Zengxiang Dong
Publikováno v:
Thrombosis Research. 180:87-97
Patients with colorectal cancer (CRC) are at increased risk of venous thrombosis, but the precise mechanisms of thrombogenesis in CRC remain largely unknown. We aimed to identify the novel role of neutrophil extracellular traps (NETs) in the inductio
Publikováno v:
Thrombosis Research. 180:74-85
Background The incretin hormone Glucagon-like peptide 1(GLP-1) plays a pivotal role in maintaining glucose homeostasis with effects also on the cardiovascular system. GLP-1 influences platelet functions by increasing the inhibitory action of nitric o