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Publikováno v:
The Journal of pharmacy and pharmacology. 46(11)
Adenosine receptor agonists inhibited electrically-evoked contractions of the rat isolated anococcygeus muscle. The compounds tested were: N6-cyclopentyladenosine (CPA), N((S, trans)-2-hydroxycyclopentyl)adenosine (GR79236), the R- and S-isomers of p
Publikováno v:
The Journal of pharmacy and pharmacology. 44(7)
The transport of ebiratide, a novel adrenocorticotropic hormone (ACTH) analogue, [H-Met-(O2)-Glu-His-Phe-d-Lys-Phe-NH(CH2)8-NH2], through the blood-brain barrier was directly demonstrated in-vivo. [125I]Ebiratide (16·9 MBq mL−1) or [14C]sucrose (2
Publikováno v:
The Journal of pharmacy and pharmacology. 44(7)
To develop a new treatment for patients with anaemia in which erythropoietin (EPO) can be given without injection, the effects of promoters of the rectal absorption of EPO were studied. Recombinant human (rHu) EPO (5000 units) in a dosing solution or
Publikováno v:
The Journal of pharmacy and pharmacology. 44(6)
Ryanodine strongly inhibited histamine release from rat peritoneal mast cells induced by anti-IgE. Ryanodine also inhibited Ca2+-mobilization from the intracellular Ca2+-store as well as histamine release in mast cells activated by anti-IgE. These re
Publikováno v:
The Journal of pharmacy and pharmacology. 44(4)
Some in-vitro pharmacological effects of a novel analogue of mianserin, 2-carboxamidino-1,2,3,4,10,14b-hexahydrodibenzo (c,f) pyrazino (1,2,-α) azepine hydrochloride (FCC5) have been studied. FCC5 was a non-competitive antagonist of both histamine-i
Publikováno v:
The Journal of pharmacy and pharmacology. 44(4)
The mechanism of relaxant activity of six benzylisoquinolines was examined in order to determine the minimal structural requirements that enable these compounds to have either a non-specific action like papaverine or an inhibitory activity on calcium
Autor:
Alberto Bianchetti, Tiziano Croci
Publikováno v:
The Journal of pharmacy and pharmacology. 44(4)
The effects of several α-adrenoceptor antagonists on faecal output and water content in rats were investigated. Fed rats were treated either subcutaneously (s.c.) or orally with phentolamine, idazoxan, yohimbine, 1-(2-pyrimidinyl) piperazine (PmP) o
Publikováno v:
The Journal of pharmacy and pharmacology. 44(3)
The effects of proteolytic enzyme inhibitors, aprotinin, soybean trypsin inhibitor and camostat mesilate as absorption enhancers on the transdermal iontophoretic delivery of salmon calcitonin (SCT) have been examined in rats. The dermal absorption of
Autor:
Baxter Gf
Publikováno v:
The Journal of pharmacy and pharmacology. 44(3)
Diltiazem administered in drinking water (0·7 mg mL−1) to Goldblatt two kidney-one clip rats over 16 weeks did not prevent the development of hypertension and left ventricular hypertrophy (LVH). When the collagen content of the left ventricles was
Publikováno v:
The Journal of pharmacy and pharmacology. 44(2)
Scatchard analyses of [3H]prazosin binding in rat ventricular muscle membranes showed biphasic curves, which identified alpha 1High- and alpha 1Low-affinity sites. The alpha 1High-affinity site was completely inhibited by 1 microM phenoxybenzamine. T