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Autor:
Glenn S. Van Aller, Kurt R. Auger, Robert H. Sinnamon, Dashyant Dhanak, Ruth Lehr, Robert A. Copeland, Robert B. Kirkpatrick, Lusong Luo, Jeffrey D. Carson, Richard R. Gontarek, Peter J. Tummino
Publikováno v:
The Biochemical journal. 409(2)
The PIK3CA gene, encoding the p110α catalytic subunit of Class IA PI3Ks (phosphoinositide 3-kinases), is frequently mutated in many human tumours. The three most common tumour-derived alleles of p110α, H1047R, E542K and E545K, were shown to potentl