Zobrazeno 1 - 10
of 11
pro vyhledávání: ''
Autor:
Zhigang Tian, Xiaokun Shen, Rui Sun, Chuang Guo, Binqing Fu, Haiming Wei, Jiabin Li, Dongyao Wang, Ying Ye, Junfei Zhang, Yanyan Liu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 1
Autor:
Tong Dai, Bin Wang, Linghui Zeng, Fangfang Zhou, Lei Zhang, Long Zhang, Yetian Dong, Jun Huang, Haiyan Yan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-14 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). To halt the pandemic, multiple SARS-CoV-2 vaccines have been developed and several have been allowed for emergency use and rol
Autor:
Ying Zhang, Junbo Liang, Zhewen Wei, Mei Liu, Qing Zhu, Chunfeng Qu, Mo Li, Yarui Ma, Huan He, Jianqiang Cai, Yi Xin Zeng, Xiaobing Wang, Yuchen Jiao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Aflatoxin exposure is a crucial factor in promoting the development of primary hepatocellular carcinoma (HCC) in individuals infected with the hepatitis virus. However, the molecular pathways leading to its bioactivation and subsequent toxicity in he
Autor:
Muhammad Adnan Shereen, Siyu Liu, Miaomiao Yue, Shanyu Huang, Xiang Li, Jianguo Wu, Peiyi Zhao, Kailang Wu, Chengliang Zhu, Wenbiao Wang, Xiao Yu, Mingfu Tian, Qiwei Zhang, Yongkui Li, Weiyong Liu, Zhen Luo, Xulin Chen, Pan Pan
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cytokine storm induced by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a major pathological feature of Coronavirus Disease 2019 (COVID-19) and a crucial determinant in COVID-19 prognosis. Understanding the mechanism underlying the
Autor:
Angang Yang, Baile Zuo, Wenjin Xi, Rui Zhang, Wei-Hong Wen, Zhangyan Guo, Lin-Tao Jia, Weimiao Li, Guoxu Zheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Despite the successful use of the humanized monoclonal antibody trastuzumab (Herceptin) in the clinical treatment of human epidermal growth factor receptor 2 (HER2)-overexpressing breast cancer, the frequently occurring drug resistance remains to be
Autor:
Xiaofei Zhou, Shao Cong Sun
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cancer immunotherapy has become an attractive approach of cancer treatment with tremendous success in treating various advanced malignancies. The development and clinical application of immune checkpoint inhibitors represent one of the most extraordi
Autor:
Nissar A. Wani, Parvaiz Yousuf, Ajaz A. Bhat, Surinder K. Batra, Shyam S. Chauhan, Mohammad Haris, Davide Bedognetti, Mushtaq A. Siddiqi, Muzafar A. Macha, Arshi Rizwan, Wael El-Rifai, Michael P. Frenneaux
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-15 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and immunosuppressive nature of HNSCC. D
Autor:
Wu Zhong, Zhihong Wu, Yingmei Feng, Jie Ma, Yunping Zhu, Danlei Mou, Ling Leng, Luye Lv, Zhongjie Hu, Hongjun Li, Feng Gong, Jiang Zhao, Shikun Zhang, Wei Li, Ruiyuan Cao, Yan Dai, Haiping Xiang, Lei Zhao, Bintao Qiu, Dunqin Gao
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-9 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The COVID-19 pandemic has emerged as a global health emergency due to its association with severe pneumonia and relative high mortality. However, the molecular characteristics and pathological features underlying COVID-19 pneumonia remain largely unk
Autor:
Bo Huang, Xiaochun Wan, Jinyan Liu, Li Yang, Shasha Liu, Youhai H. Chen, Zhixin Zhang, Yi Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-8 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected patients worldwide. The host immune response to SARS-CoV-2 appears to play a crit
Autor:
Hongchun Liu, Li Yang, Mengying Yao, Jianbo Gao, Jianjun Gou, Lihua Xing, Zhiqiang Zhu, Lan Huang, Yi Zhang, Shaofei Ji
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-3 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy