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Autor:
Xuejin Ou, Dan Li, Kai Li, Yue Chen, Houhui Shi, Yongsheng Wang, Benxia Zhang, Qizhi Ma, Pei Shu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-25 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature myeloid cells with immunosuppressive effects, which undergo massive expansion during tumor progression. These cells not only support immune escape directly but also pro
Autor:
Yan Zheng, Haoting Sun, Mo Chen, Yuan-Yuan Sheng, Lun-Xiu Qin, Qiongzhu Dong, Xudong Ren, Qin Luo, Bei-Yuan Hu, Yan Geng, Tiantian Zou, Xiao-Mei Gao, Kai-Li Zhang, Chaoqun Wang, Lu-Yu Yang, Shican Yan, Yan Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-12 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Intercellular cross-talk plays important roles in cancer progression and metastasis. Yet how these cancer cells interact with each other is still largely unknown. Exosomes released by tumor cells have been proved to be effective cell-to-cell signal m
Autor:
Dewei Jiang, Wenli Liu, Aiham Qdaisat, Lu Li, Haixia Wang, Sai Ching J. Yeung, Wenjing Liu, Runxiang Yang, Rong Liu, Zhongmei Zhou, Ceshi Chen, Jiao Wu, Sicheng Liu, Chuanyu Yang, Zhuo Cheng
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-13 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Weight loss and cachexia are common problems in colorectal cancer patients; thus, parenteral and enteral nutrition support play important roles in cancer care. However, the impact of nonessential amino acid components of nutritional intake on cancer
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-20 (2021)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates prac
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-14 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Cancer immunotherapy especially immune checkpoint inhibition has achieved unprecedented successes in cancer treatment. However, there are many patients who failed to benefit from these therapies, highlighting the need for new combinations to increase
Autor:
Tongtong Qi, Qifeng Sun, Yi Huang, Guimei Lin, Yanbin Shi, Shengnan Qiu, Xiaogang Zhao, Xianglei Fu
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-15 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Therapeutic efficacy against cancer relies heavily on the ability of the therapeutic agents to reach their final targets. The optimal targets of most cancer therapeutic agents are usually biological macromolecules at the subcellular level, which play
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-11 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Esophageal cancer (EC) is one of the most lethal cancers in the world, and its morbidity and mortality rates rank among the top ten in China. Currently, surgical resection, radiotherapy and chemotherapy are the primary clinical treatments for esophag
Autor:
Qiuyong Guo, Weihan He, Lei Wang, Hongjuan Xu, Xingjun Jiang, Yuanbo Kang, Jingyu Hu, Jincheng Qiao, Caiping Ren
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-20 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Nasopharyngeal carcinoma (NPC) is a malignant epithelial carcinoma of the head and neck region which mainly distributes in southern China and Southeast Asia and has a crucial association with the Epstein–Barr virus. Based on epidemiological data, b
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-25 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated the development of the alternative strategy of drug repurposing, the development of old drugs for new therapeutic purposes. This strategy with a cost-effective w
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 4, Iss 1, Pp 1-39 (2019)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. Epigenetic dysregulation is often linked to human disease, notably cancer. With the developme