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Publikováno v:
RNA (New York, N.Y.), vol 27, iss 12
Understanding transcriptomes requires documenting the structures, modifications, and abundances of RNAs as well as their proximity to other molecules. The methods that make this possible depend critically on enzymes (including mutant derivatives) tha
Publikováno v:
RNA
Many antibiotics that bind to the ribosome inhibit translation by blocking the movement of tRNAs and mRNA or interfering with ribosome dynamics, which impairs the formation of essential translocation intermediates. Here we show how translocation inhi
Autor:
Ekaterina S. Komarova, Andrey G Tereshchenkov, Petr V. Sergiev, Dmitrii I. Shiriaev, Ilya A. Osterman, Alexander G. Myasnikov, Andrey L. Konevega, Yury S. Polikanov, Evgeny Pichkur, Alexey A. Bogdanov, Alena Paleskava, Pavel Kasatsky, Olga A. Dontsova
Publikováno v:
RNA
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
RNA, 2020, 26 (6), pp.715-723. ⟨10.1261/rna.073817.119⟩
Macrolides are one of the most successful and widely used classes of antibacterials, which kill or stop the growth of pathogenic bacteria by binding near the active site of the ribosome and interfering with protein synthesis. Dirithromycin is a deriv
Publikováno v:
RNA
During tRNA maturation in yeast, aberrant pre-tRNAs are targeted for 3′–5′ degradation by the nuclear surveillance pathway, and aberrant mature tRNAs are targeted for 5′–3′ degradation by the rapid tRNA decay (RTD) pathway. RTD is catalyz
Publikováno v:
RNA
Assessing variations in mRNA stability typically involves inhibiting transcription either globally or in a gene-specific manner. Alternatively, mRNA pulse-labeling strategies offer a means to calculate mRNA stability without inhibiting transcription.
PKR activation by noncanonical ligands: a 5′-triphosphate requirement versus antisense contamination
Publikováno v:
RNA
Protein kinase RNA-activated (PKR) is an interferon-inducible kinase that is potently activated by long double-stranded RNA (dsRNA). In a previous study, we found that snoRNAs exhibit increased association with PKR in response to metabolic stress. Wh
Autor:
Elena Plessa, Anthony Bougas, Yury S. Polikanov, George P. Dinos, Maxim S. Svetlov, Marios G. Krokidis, Chih-Wei Chen
Publikováno v:
RNA
The 70S ribosome is a major target for antibacterial drugs. Two of the classical antibiotics, chloramphenicol (CHL) and erythromycin (ERY), competitively bind to adjacent but separate sites on the bacterial ribosome: the catalytic peptidyl transferas
Publikováno v:
RNA. 25:232-238
Most microRNAs (miRNAs) are expressed as a mix of length isoforms (referred to as isomiRs). IsomiR stoichiometry can be differentially impacted upon cell stimulation, as recently evidenced by our group in the context of immune responses induced by ty
Autor:
Stefan Günther, David E. Surate Solaligue, Susanne Herold, Maximilian J. Daume, Ivana Mižíková, Rory E. Morty, István Vadász, Werner Seeger, Jonas Hönig, Konstantin Mayer, Claudio Nardiello
Publikováno v:
RNA. 24:865-879
The emergence of microRNA as regulators of organogenesis and tissue differentiation has stimulated interest in the ablation of microRNA expression and function during discrete periods of development. To this end, inducible, conditional modulation of
Publikováno v:
RNA. 23:1237-1246
miRNAs have emerged as key participants of p53 signaling pathways because they regulate or are regulated by p53. Here, we provide the first study demonstrating direct regulation of an oncogenic miRNA, miR-191-5p, by p53 and existence of a regulatory