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Autor:
Jenna R. Gale, Noreen M. Gervasi, Shane S. Scott, Armaz Aschrafi, Amar N. Kar, Barry B. Kaplan, Margaret A. MacGibeny, Anthony E. Gioio, Sanah N. Vohra
Publikováno v:
RNA. 22:883-895
Synthesis and regulation of catecholamine neurotransmitters in the central nervous system are implicated in the pathogenesis of a number of neuropsychiatric disorders. To identify factors that regulate the presynaptic synthesis of catecholamines, we
Publikováno v:
RNA. 20:392-405
Adenosine-to-inosine (A-to-I) RNA editing is an endogenous regulatory mechanism involved in various biological processes. Site-specific, editing-state–dependent degradation of target RNA may be a powerful tool both for analyzing the mechanism of RN
Publikováno v:
RNA. 19:1309-1314
2-Selenouridine (SeU) is one of the naturally occurring modifications of Se-tRNAs (SeU-RNA) at the wobble position of the anticodon loop. Its role in the RNA-RNA interaction, especially during the mRNA decoding, is elusive. To assist the research exp
Autor:
Andrzej Fligier, Paulina Galka-Marciniak, Wlodzimierz J. Krzyzosiak, Katarzyna Polak, Marta Olejniczak
Publikováno v:
RNA. 18:930-935
The RNAimmuno database was created to provide easy access to information regarding the nonspecific effects generated in cells by RNA interference triggers and microRNA regulators. Various RNAi and microRNA reagents, which differ in length and structu
Autor:
Andres M. Patino, Julianne Caton-Williams, Zhen Huang, Jaya Punetha, Manindar Kaur, Lina Lin, Jia Sheng
Publikováno v:
RNA. 17:1932-1938
Phosphoroselenoate RNA (PSe-RNA) is nuclease resistant and has great potentials in X-ray crystal structure and function studies of noncoding RNAs and protein–RNA interactions. In order to conveniently synthesize PSe-RNA via transcription, we have d
Autor:
Shigeyuki Yokoyama, Sakurako Goto-Ito, Georges Lahoud, Ya-Ming Hou, Ken-ichi Yoshida, Takuhiro Ito
Publikováno v:
RNA. 17:1236-1246
Bacterial TrmD and eukaryotic-archaeal Trm5 form a pair of analogous tRNA methyltransferase that catalyze methyl transfer from S-adenosyl methionine (AdoMet) to N1 of G37, using catalytic motifs that share no sequence or structural homology. Here we
Autor:
Daniel M. Dupont, Frédéric Ducongé, Jeppe B. Madsen, Bertrand Tavitian, Roland K. Hartmann, Jørgen Kjems, Peter A. Andreasen
Publikováno v:
Dupont, D M, Madsen, J B, Hartmann, R K, Tavitian, B, Ducongé, F, Kjems, J & Andreasen, P A 2010, ' Serum-stable RNA aptamers to urokinase-type plasminogen activator blocking receptor binding ', RNA, vol. 16, no. 12, pp. 2360-9 . https://doi.org/10.1261/rna.2338210
The serine proteinase urokinase-type plasminogen activator (uPA) is widely recognized as a potential target for anticancer therapy. Its association with cell surfaces through the uPA receptor (uPAR) is central to its function and plays an important r
Publikováno v:
RNA. 15:911-922
The structure of a cytosine–cytosine (CC) mismatch-containing RNA molecule derived from a hairpin structure in the thymidylate synthase mRNA that binds the aminoglycoside paromomycin with high affinity was determined using nuclear magnetic resonanc
Autor:
Céline Chauvin, Olivier Jean-Jean
Publikováno v:
RNA. 14:240-245
In eukaryotes, eRF1 and eRF3 are associated in a complex that mediates translation termination. The regulation of the formation of this complex in vivo is far from being understood. In mammalian cells, depletion of eRF3a causes a reduction of eRF1 le
Autor:
Beatrix Suess, Sabrina Zeiher, Martin Sanchez, Renée Schroeder, Ewald Bernd Gunnesch, Julia E. Weigand
Publikováno v:
RNA. 14:89-97
Riboswitches are genetic control elements that regulate gene expression in a small molecule-dependent way. We developed a two-stage strategy of in vitro selection followed by a genetic screen and identified several artificial small molecule-binding r