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Autor:
Ronan Joyce, Timothy J. Counihan, Silive Blazkova, Patrick Moynagh, Luke Francis O'Donnell, Shane Lyons
Publikováno v:
Practical Neurology. 20:256-259
Immune checkpoint inhibitors have transformed the treatment of advanced malignancy, while increasing the risk of immune-related adverse events. A 56-year-old woman who had received nivolumab for stage 4 renal cell carcinoma subsequently developed alt
Publikováno v:
Practical Neurology. 20:148-153
Cytotoxic agents such as cyclophosphamide are infrequently used in neurological practice. When they are, it is commonly in critically ill patients or in those with refractory inflammatory disorders. Cyclophosphamide in particular has a well-recognise
Publikováno v:
Practical Neurology. 19:508-510
A young woman with systemic lupus erythematosus (SLE) developed recurrent enterovirus meningoencephalitis while taking prednisolone, azathioprine and rituximab. After reducing the immunosuppression, she developed a central nervous system (CNS) flare
Publikováno v:
Practical Neurology. 17:145-148
The syndrome of headache with neurologic deficits and cerebrospinal fluid lymphocytosis (HANDL) is rare; it comprises migrainous headaches (generally in headache-naïve people), fluctuating neurological symptoms and cerebrospinal fluid (CSF) lymphocy
Autor:
Olivier Gout, Celeste Rebours, Arthur Mageau, Natalia Shor, Matthieu Fisselier, Augustin Lecler, Jennifer Aboab, Homa Adle-Biassette, Romain Deschamps
Publikováno v:
Practical Neurology. 18:159-161
IgG4-related disease is now recognised as an important cause of intracranial and spinal hypertrophic pachymeningitis. Treatment with corticosteroids generally leads to significant clinical improvement. We present two cases of IgG4 pachymeningitis unr
Publikováno v:
Practical Neurology. 15:141-144
We describe two women presenting with severe postpartum headache associated with hypertension but with no other signs or investigation results to suggest pre-eclampsia. In one case, the headache was associated with atypical subarachnoid haemorrhage.
Publikováno v:
Practical Neurology. 12:36-39
A 70-year-old woman reported recurrent episodes of right- or left-sided sensorimotor disturbance, thought to be recurrent transient ischaemic attacks. The episodes continued despite treatment with antiplatelet agents. When MRI revealed microhaemorrha
Publikováno v:
Practical Neurology. 17:133-134
Memantine is an uncompetitive N -methyl-d-aspartate receptor antagonist and probably also has an indirect dopaminergic action at high concentrations. We describe a person with Alzheimer9s disease who developed chorea and dystonia after inadvertently
Autor:
Lisk Dr
Publikováno v:
Practical Neurology. 9:42-45
Kleine-Levin syndrome, sometimes referred to as Rip van Winkle disease, is a rare sleep disorder mainly affecting teenage boys in which the main features are intermittent hypersomnolence, behavioural and cognitive disturbances, hyperphagia and in som
Publikováno v:
Practical Neurology. 15:214-215
Methotrexate is a folate antagonist and one of several first-line disease-modifying drugs for treating rheumatoid arthritis. It can be given orally or parenterally: the bioavailability of oral doses of methotrexate is highly variable, being only two-